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| 1 | Measuring consciousness in coma and related states显示文摘Consciousness is a prismatic and ambiguous concept that still eludes any universal definition. Severe acquired brain injuries resulting in a disorder of con-sciousness(DOC) provide a model from which insights into consciousness can be drawn. A number of recent studies highlight the difficulty in making a diagnosis in patients with DOC based only on behavioral assessments. Here we aim to provide an overview of how neuroimaging techniques can help assess patients with DOC. Such techniques are expected to facilitate a more accurate understanding of brain function in states of unconsciousness and to improve the evaluation of thepatient's cognitive abilities by providing both diagnostic and prognostic indicators. | Carol Di Perri Aurore Thibaut Lizette Heine Andrea Soddu Athena Demertzi Steven Laureys | 2014 | World Journal of Radiology2014，6，8： | 11 |
| 2 | Common genetic variants in the TP53 pathway and their impact on cancer显示文摘The TP53 gene is well known to be the most frequently mutated gene in human cancer.In addition to mutations,there are > 20 different coding region single-nucleotide polymorphisms (SNPs) in the TP53 gene,as well as SNPs in MDM2,the negative regulator of p53.Several of these SNPs are known to alter p53 pathway function.This makes p53 rather unique among cancer-critical genes,e.g.the coding regions of other cancer-critical genes like Ha-Ras,RB,and PI3KCA do not have non-synonymous coding region SNPs that alter their function in cancer.The next frontier in p53 biology will consist of probing which of these coding region SNPs are moderately or strongly pathogenic and whether they influence cancer risk and the efficacy of cancer therapy.The challenge after that will consist of determining whether we can tailor chemotherapy to correct the defects for each ofthese variants.Here we review the SNPs in TP53 and MDM2 that show the most significant impact on cancer and other diseases.We also propose avenues for how this information can be used to better inform personalized medicine approaches to cancer and other diseases. | Thibaut Barnoud Joshua L.D.Parris Maureen E.Murphy | 2019 | Journal of Molecular Cell Biology2019，11，7： | 7 |
| 3 | 粉末型硅烷/有机硅添加剂在水泥基材中的应用显示文摘介绍了有机硅作为憎水剂在水泥基材料中的作用,介绍了有机硅粉状憎水剂的主要组分及其性能。通过实验证明,有机硅粉状添加剂SHP50及SHP60是一种高效的憎水剂,应用于水泥基干混材料中,赋予了砂浆良好的疏水特性。 | Jean-Paul LECOMTE Marc Thibaut | 2009 | 化学建材2009，，4： | 5 |
| 4 | Comparison and relative quality assessment of the GLC2000, GLOBCOVER, MODIS and ECOCLIMAP land cover data sets at the African continental scale显示文摘 | Armel Thibaut Kaptué Tchuenté Jean-Louis Roujean Steven M. De Jong | 2010 | International Journal of Applied Earth Observations and Geoinformation2010，，2： | 2 |
| 5 | Consequences of coinfection with protective symbionts on the host phenotype and symbiont titres in the pea aphid system显示文摘在微生物和昆虫之间的共生协会是普遍的,并且几个共生者分享一样的主人个人,是经常的。因此,相互作用能发生在这些共生者之间,影响他们在有它的显型上的后果的主人以内的各自的丰富。这里,我们在豌豆蚜虫调查多重感染的效果, Acyrthosiphon pisum,它是主人一应尽并且几个容许的共生者。特别地,我们与 2 个保护的共生者学习 coinfection 的影响:Hamiltonella defensa,它对 parasitoids 授与保护,和 Rickettsiella viridis。各自的许多上的 Hamiltonella-Rickettsiella coinfection 的效果共生者,主人健康和敌人保护的功效被学习。在 2 个保护的共生者之间的不均匀的相互作用被发现了:什么时候他们 coinfect 一样的蚜虫个人,当 Hamiltonella 感染否定地影响调停 Rickettsiella 的保护的显型然而并非它的丰富时, Rickettsiella 感染在主人然而并非调停 Hamiltonella 的保护的显型以内影响了 Hamiltonella 丰富。怀有 2 个保护的共生者也减少了主人个人的幸存和肥沃。总的来说,这个工作在是可能的在自然产地影响共生协会的维护的共生者丰富和主人特点上加亮多重感染的效果。 | Melanie Leclair Sarah Polin Thibaut Jousseaume Jean-Christophe Simon Akiko Sugio Stephanie Morliere Takema Fukatsu Tsutomu Tsuchida Yannick Outreman | 2017 | Insect Science2017，24，5： | 2 |
| 6 | An Investigation of Freezing of Supercooled Water on Anti-Freeze Protein Modified Surfaces显示文摘 | Thibaut V J Charpentier Anne Neville Paul Millner Rob Hewson Ardian Morina | 2013 | Journal of Bionic Engineering2013，10，2： | 2 |
| 7 | Characterization of meso-scale mechanical properties of Longmaxi shale using grid microindentation experiments显示文摘Mechanical properties,such as the hardness H,Young’s modulus E,creep modulus C,and fracture toughness Kc,are essential parameters in the design of hydraulic fracturing systems for prospective shale gas formations.In this study,a practical methodology is presented for obtaining these properties through microindentation experiments combined with quantitative observations of the mineralogical phases using X-ray diffraction(XRD),scanning electron microscopy(SEM)with backscattered electron(BSE)imaging,and energy-dispersive X-ray spectroscopy(EDS)analyses.We apply this method in the case of three types of Longmaxi shales with different mineralogies(i.e.carbonate-,clay-,and quartz-rich,respectively),which allows us to determine the characteristic indentation depth,hc?8e10 mm,beyond which the mechanical response of the carbonate-rich shale is homogeneous and independent of its complex heterogeneous microstructure.Moreover,exploiting the results of a large number of indentation tests,we demonstrate that the indentation modulus M of the shale increases as a power-law of hardness H,and its creep modulus C increases linearly with H.We also compute the fracture toughness Kc from the indentation data by assuming a perfectly plastic behavior of the sample.Our results are in good agreement with independent measurements of Kc determined by microscratch tests.Finally,further tests on quartz-and clay-rich samples of the Longmaxi shale suggest further variations in the samples’mechanical properties depending on their burial conditions and the mechanical properties of their dominant mineral phases. | Jianting Du Andrew J.Whittle Liming Hu Thibaut Divoux Jay N.Meegoda | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 2 |
| 8 | Association study between schizophrenia and monoamine oxidase A and B DNA polymorphisms显示文摘 | Coron B Campion D Thibaut F | 1996 | Psychiatry Res1996，62，3： | 1 |
| 9 | Human hair shape is programmed from the bulb显示文摘 | Thibaut S Gaillard O Bouhanna P | 2005 | Br J Derma- tol2005，152，： | 1 |
| 10 | Purification of the two-enzyme system catalyzing the oxidation of the D-proline residue of pristinamycin ⅡB during the last step of pristinamycin ⅡA biosynthesis 显示文摘 | Thibaut D Ratet N Bisch D | 1995 | J Bacteriol1995，177，18： | 1 |
| 11 | Organ procurement from donors deceased from cardiac death: a single-center efficiency assessment 显示文摘 | Billauh C Godfroy F Thibaut F | 2011 | Transplant Proc2011，43，9： | 1 |
| 12 | From unre- sponsive wakefulness to minimally conscious PLUS and func- tional locked-in syndromes: recent advances in our understand- ing of disorders of consciousness 2011 显示文摘 | Bruno MA Vanhaudenhuyse A Thibaut A | 2011 | Neurol2011，258，7： | 1 |
| 13 | The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and-independent mechanisms显示文摘 | Arnaud E Ferri KF Thibaut J | 2006 | Cell Death Differ2006，13，7： | 1 |
| 14 | Morphology and molten-state rheology of polylactide and polyhydroxyalkanoate blends显示文摘 | THIBAUT Gerard TATIANA Budtova | 2012 | European Polymer Journal2012，，48： | 1 |
| 15 | Different types of T - effector cells orchestrate mucosal inflammation in chronic sinus disease显示文摘 | ZHANG N THIBAUT V Z | 2008 | J Allergy Clin Immunol2008，122，5： | 1 |
| 16 | Simulation and thermoeconomic analysis of different configuration of gas turbine(GT)-based dual-purpose power and desalination plants(DPPDP)and hybrid plants(HP)显示文摘 | Thibaut Rensonnet Javier Uche Luis Serra | 2007 | Energy2007，32，： | 1 |
| 17 | The development of contractual norras in bargaining replication and variation显示文摘 | Thibaut J W | 1968 | Journal of Conflict Resolution1968，，： | 1 |
| 18 | Wet industrial flue gas desulfurization unit: model development and validation on industrial data显示文摘 | Neveux Thibaut Le Moullec Yann | 2011 | Industrial & Engineering Chemistry Research2011，50，2： | 1 |
| 19 | Combating enterovirus replication: state-of-the-art on antiviral research显示文摘 | Thibaut HJ De Palma AM Neyts J | 2012 | Biochem Pharmacol2012，83，2： | 1 |
| 20 | OX40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo显示文摘 | Jeffrey S Peter B | 2002 | J Immunol2002，168，： | 1 |
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