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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | 肝胰十二指肠切除术治疗胆道恶性肿瘤的指征显示文摘肝胰十二指肠切除术(hepatopancreatoduodenectomy,HPD)治疗胆道肿瘤的指征目前仍有争议,主要原因是HPD手术创伤大,术后死亡率和手术并发症发生率很高。该文回顾性总结11例HPD治疗进展期胆道恶性肿瘤的经验,探讨HPD的应用指征。1986-2004年日本Wakayama医科大学医院共收治219例胆道恶性肿瘤病人,包括146例胆管癌和73例胆囊癌,其中11例(5%)因弥漫性胆管癌或进展期胆囊癌需广泛清除肿瘤和转移淋巴结而进行了HPD手术治疗。 | Hirono S Tani M Kawai M 邹一平(摘) 萧荫祺(校) | 2006 | 中华肝胆外科杂志2006，12，11： | 2 |
| 3 | Zygosporin D and two new cytochalasins produced by the fungus Metarrhizium anisopliae显示文摘 | Fujii Y Tani H Ichinoe M | 2000 | J Nat Prod2000，63，： | 1 |
| 4 | Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis显示文摘 | Tani T H Khodursky A Blumenthal R M | 2002 | Proc NatlAcadSciUSA2002，99，13： | 1 |
| 5 | In vitro construction of scaffold--free cylindrical cartilage using cell sheet--based tis- sue engineering显示文摘 | Tani G Usui N Kamiyama M | 2010 | Pediatr Surg Int2010，26，： | 1 |
| 6 | Expression of the ELM1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family,suppresses in vivo tumor growth and metastasis of K-1735 murine melanoma cells 显示文摘 | Hashimoto BY Shindo-Okada N Tani M | 1998 | J Exp Med1998，187，3： | 1 |
| 7 | Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions显示文摘 | Tanaka K Tani T Tanaka M | 2007 | Mult Scler2007，13，7： | 1 |
| 8 | Medium and long-term results of jejunal pouch reconstruction after a total and proximal gastrectomy显示文摘 | Takeshita K Sekita Y Tani M | 2007 | Surg Today2007，37，9： | 1 |
| 9 | Gratitude in Univer- sity Students in Japan and Thailand显示文摘 | NAITO T WANGWAN J TANI M | 2005 | Journal of Cross- Cultural Psychology2005，36，2： | 1 |
| 10 | Effects of myrloid cell groath factors on alkakine phosphatase, myrloperixidase, defensin and granuloeyte cotonystimulating factor receptor mRNA expression in haemopoietic cells of normal individuals and myeloid disorders显示文摘 | Tsuruta T Tani K Shimane M | 1996 | Br J Haematol1996，92，： | 1 |
| 11 | Chemokines and chemokine receptors in inflammatory demyelinating neuropathies显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，4： | 1 |
| 12 | Histologic and biochemical alte- rations in experimental acute pancreatitis induced bysupramnaxmial caemlein stimulation 显示文摘 | Tani S Otsuki M Itoh H | 1987 | In J Panereatol1987，2，： | 1 |
| 13 | Online analysis of volatile organic compound emissions from Sitka spruce (Picea sitchensis) 显示文摘 | HAYWARD S TANI A OWENS M | 2004 | Tree Physiology2004，24，7： | 1 |
| 14 | Laser-driven metal exchange and preparation of metal pathaloeyanine显示文摘 | SATO H NISHIO S TANI M | 1999 | Appl Phys Suppl1999，69，： | 1 |
| 15 | Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon 显示文摘 | Hinoi T Tani M Lucas PC etal | 2001 | Am J Pathol2001，159，6： | 1 |
| 16 | Severe fever with thrombocytopenia syndrome in Japan 显示文摘 | Shimojima M Fukushi S Tani H | 2013 | Uirusu2013，63，1： | 1 |
| 17 | Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes 显示文摘 | Ito K Anada Y Tani M | 2007 | Biochem Biophys Res Commun2007，357，： | 1 |
| 18 | The anthocyanin delphinidin 3-rutinoside stimulates glucagonlike peptide-1 secretion in murine GLUTag cell line via the Ca2+/calmodulin-dependent kinaseⅡpathway显示文摘 | Kato M Tani T Terahara N Tsuda T | 2015 | PLo S One2015，10，01： | 1 |
| 19 | Pylorus - preserving pancreaticoduodenectomy versus conventional pancreaticoduodenectomy for pancreatic adenocarcinoma 显示文摘 | Tani M Kawai M Hirono S | 2009 | Surg Today2009，39，3： | 1 |
| 20 | Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenec- tomy: a prospective, randomized, controlled trial of pylorus- resec- ring versus pylorus-preserving pancreatoduodeneetomy 显示文摘 | Kawai M Tani M Hirono S | 2011 | Ann Surg2011，253，3： | 1 |
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