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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | Overview and comparison of guidelines for management of pancreatic cystic neoplasms显示文摘Pancreatic cysts are identified at an increasing frequency.Although mucinous cystic neoplasms represent a pre-malignant condition,the majority of these lesions do not progress to cancer.Over the last 10 years several societies have established guidelines for the diagnosis,initial evaluation and surveillance of these lesions.Here we provide an overview of five commonly used guidelines:2015 American Gastroenterological Association,2017 International Association of Pancreatology,American College of Gastroenterology 2018,European Study Group and American College of Radiology.We describe the similarities and differences between the methods used to formulate these guidelines,the population they target and their approaches towards initial evaluation and surveillance of cystic lesions. | Aws Hasan Kavel Visrodia James J Farrell Tamas A Gonda | 2019 | World Journal of Gastroenterology2019，25，31： | 5 |
| 3 | Comparison of long-term outcome between patients aged 〈 65 years vs. ≥ 65 years after atrial fibrillation ablation显示文摘Background Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to com-pare the long-term outcome data of patients 〈 65 years vs.≥ 65 years who underwent catheter ablation (CA) for drug-refractory AF. MethodsConsecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completeda five-year of follow-up were divided into two groups: patients aged 〈 65 years into group 1, and patients aged ≥ 65 into group 2. Long-termoutcome data concerning mortality, thromboembolic events (TE) and success rates were compared between these groups. Results A totalnumber of 390 patients were included, group 1 contained 310 patients, and 80 patients in group 2. In group 2, patients had more often impairedrenal function (P 〈 0.001) and thyroid disease (P = 0.047). A total of fifteen patients died during the 6.63 ± 2.1 years of follow-up, with a sig-nificantly higher incidence in the older group (8/80 vs. 7/310 patients, P = 0.004). The majority of fatal outcome was due to cancerous dis-eases in both groups. No difference was observed concerning the long-term TE rate (12/310 vs. 4/80 patients, P = 0.75). Rhythm controlfailed in 25.9% of the patients, with no difference between the groups: 26.4% in group 1 vs. 23.7% in group 2 (P = 0,67), ConclusionsDespite growing prevalence of AF in aging population, the elderly patients are underrepresented in CA procedures. Similar clinical successand TE complication rate are observed between the age-groups. Our data suggest more liberal criteria might be applied while selecting pa-tients for AF ablation. | Zsuzsanna Kis Anna ME Noten Mihran Martirosyan Astrid A Hendriks Rohit Bhagwandien Tamas Szili-Torok | 2017 | Journal of Geriatric Cardiology2017，14，9： | 3 |
| 4 | Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca^2+ in T lymphocytes显示文摘 | Tamas P Hawley S A Clarke R G | 2006 | J Exp Med2006，203，7： | 1 |
| 5 | Examination of sensorimotor performance following middle cerebral artery occlusion in rats显示文摘 | Reglodi D Tamas A Lengvari I | 2003 | Brain Res Bul2003，59，6： | 1 |
| 6 | Histone H3 transcript stability in alfalfa显示文摘 | Tamas K Robertson A J Waterborg J H | 1995 | Plant Molecular Biology1995，28，： | 1 |
| 7 | Role of PACAP in female fertility and reproduction at gonadal level-recent advances显示文摘 | Reglodi D Tamas A Koppan Mi | 2012 | Front Endocrinol(Lausanne)2012，3，： | 1 |
| 8 | Coupled ocean-atmosphere inter-decadal modes in the tropics显示文摘 | Goswami B N Tamas M A | 2000 | J Meteorol Soc Japan2000，78，6： | 1 |
| 9 | Metabolic consequences of orthotopic ideal neobladder显示文摘 | Repassy DL Becsi A Tamas G | 1999 | Acta Chir Hung1999，38，： | 1 |
| 10 | Strain and culture conditions improvement for 15 -carotene production with Mucor显示文摘 | ENRIQUE A TAMAS P JESPEN B | 2005 | Microbiol Processes and Products2005，18，： | 1 |
| 11 | Effect of plant growth substances on the growth of axillary buds in cultured stem segments of Phaseolus vulgaris L显示文摘 | Tamas I A Schlossberg-Jacobs J L Lim R | 1998 | Plant Growth Regul1998，8，： | 1 |
| 12 | The hepatoprotective action of ten herbal extracts in CCI intoxicated liver显示文摘 | RUSU M A TAMAS M PUICA C | 2005 | Phytother Res2005，19，9： | 1 |
| 13 | The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus显示文摘 | Tabak AG Tamas G Peterfalvi A | 2009 | J Endocrinol Invest2009，32，： | 1 |
| 14 | Modelling soil - sweep inter- action with discrete element method 显示文摘 | Tamas K Jori I J Mouazen A M | 2013 | Soil and Tillage Re-search2013，134，： | 1 |
| 15 | Histopathologic features and clinical outcomes in 71 cases of bladder diverticula 显示文摘 | Tamas E F Stephenson A J Campbell S C | 2009 | Arch Pathol Lab Med2009，133，5： | 1 |
| 16 | Metabolic consequences of orthotopoic ileal neobladder 显示文摘 | REPASSY DL BECSI A TAMAS G | 1999 | Acta Chir Hung1999，38，3： | 1 |
| 17 | Examination of sen- sorimotor performance following middle cerebral artery occlu- sion in rats 显示文摘 | REGLODI D TAMAS A LENGVARI I | 2003 | Brain Res Bull2003，59，6： | 1 |
| 18 | Olter membrane proteins ofPasteurella multodida 显示文摘 | TAMAS H KE1TH A H JOHN D B | 2010 | Vet Microbiol2010，144，： | 1 |
| 19 | Growth of 'dizzy dendrites' in a random field of foreign particles显示文摘 | Laszlo Granasy Tamas Pusztail James A Warren | 2003 | Nature Materials2003，2，1： | 1 |
| 20 | Examination of sensorimotor performance following middle cerebral artery occlusion in rats 显示文摘 | Reglodi D Tamas A Lengvari 1 | 2003 | Brain Res Bull2003，59，6： | 1 |
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