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| 1 | Effects of octreotide on acute necrotizing pancreatitis in rabbits显示文摘AIM: To assess the role of oxygen-derived free radicals and cytokines in the pathogenesis of taurocholic acid-induced acute pancreatitis, and to evaluate the preventive effects of octreotide towards the development of acute pancreatitis. METHODS: Acute pancreatitis was induced in male New Zealand white rabbits by retrograde injection of 0.8 mL/kg·b·m, of 50 g/L sodium taurocholate(NaTC) in the pancreatic duct. Sham-operated animals served as control. Octreotide 1 mglkg·b.m.was administered subcutaneously before the induction of pancreatitis. Blood was taken from the jugular vein before and at 1, 3, 6, 12 and 24 h after pancreatitis induction.Serum activities of amylase, IL-6 and TNF-α and levels of malonyl dialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (Mn-,Cu-,and Zn-SOD) in pancreatic tissue were measured.RESULTS: Serum TNF-α and IL-6 levels increased significantly 3 h after the onset of pancreatitis, and then returned to control level. The tissue concentration of MDA was significantly elevated at 24 h, while the GSH level and GP-x, catalase, Mn-SOD, Cu-, Zn-SOD activities were all significantly decreased in animals with pancreatitis as compared to the control. Octreotide pretreatment significantly reversed the changes in cytokines and reactive oxygen metabolites. Octreotide treatment did not alter the serum amylase activity and did not have any beneficial effects on the development of histopathological changes.CONCLUSION: Oxygen-derived free radicals and proinflammatory cytokines are generated at an early stage of NaTc-induced acute pancreatitis in rabbits. Prophylac ticoctreotide treatment can prevent release of cytokines and generation of reactive oxygen metabolites, but does not have any beneficial effects on the development of necrotizing pancreatitis. | Lászl6Czakó PéterHegyi TamásTakács CsabaGóg AndrásFarkas YvetteMándy Ilona Sz.Varga LászlóTiszlavicz JánosLonovics | 2004 | World Journal of Gastroenterology2004，10，14： | 21 |
| 2 | L-arginine-induced experimental pancreatitis显示文摘Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et. al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis.Not only is this a good model to study the pathomechanisne of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model.Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis. | PéterHegyi ZoltánRakonczayJr RékaSári CsabaGóg JánosLonovics TamásTakács LászlóCzakó | 2004 | World Journal of Gastroenterology2004，10，14： | 7 |
| 3 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 4 | Understanding the importance of autophagy in human diseases using Drosophila显示文摘Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the specific context. The majority of medical conditions including cancer, neurodegenerative diseases, infections and immune system disorders and inflammatory bowel disease could probably benefit from therapeutic modulation of the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of human disease genes and autophagic processes. Here, we provide an overview of the various autophagy pathways observed both in flies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of the above-mentioned diseases where fly research has already helped to understand how defects in autophagy genes and pathways contribute to the relevant pathomechanisms. | Arindam Bhattacharjee áron Szabó Tamás Csizmadia Hajnalka Laczkó-Dobos Gábor Juhász | 2019 | Journal of Genetics and Genomics2019，46，4： | 4 |
| 5 | Messenger RNA expression of Podoeyte- associated molecules in urinary sediment of patients with lupus nephritis 显示文摘 | WANG G LAI FM TAM LS | 2007 | J Rheumatol2007，34，12： | 1 |
| 6 | Theory of isothermal current and the direct determination of trap parameters in semiconductors and insulators containing arbitrarytrap distributions显示文摘 | Simmons J G Tam M C | 1973 | Physical Review B1973，7，： | 1 |
| 7 | Pharmacodynamics of polymyxin B against Pseudomonas aeruginosa显示文摘 | Tam VH Schilling AN Vo G | 2005 | Antimicrob Agents Chemother2005，49，9： | 1 |
| 8 | Cytotoxic chemotherapy has min- imal direct effect on gastric myoelectric activity in children with 5HT(3) antagonist prophylaxis显示文摘 | Cheng W Chan G C Tam P K | 2000 | Med Pediatr Oncol2000，34，6： | 1 |
| 9 | Circulating unmetabolized folic acid: relationship to folate status and effect of supplementation 显示文摘 | Tam C O'Connor D Koren G | 2012 | Obstet Gynecol Int2012，2012，48： | 1 |
| 10 | Biocompatibility of alginate-poly-l-lysine microcapsules for cell therapy显示文摘 | Orive G Tam SK Pedraz JL | 2006 | Biomaterials2006，27，20： | 1 |
| 11 | Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?显示文摘 | P. Ferdinandy Tamás Csont Csaba Csonka Marianna T?r?k Mária Dux József Németh László I. Horváth László Dux Zoltán Szilvássy Gábor Jancsó | 1997 | Naunyn - Schmiedeberg’s Archives of Pharmacology1997，，3： | 1 |
| 12 | Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus显示文摘 | Wang G Tam L S Li E K | | 0，，12： | 1 |
| 13 | Products of ozone-initiated chemistry in a simulated aircraft environment显示文摘 | Wisthaler A Tamás G Wyon D P Strφm-Tejsen P Space D Beauchamp J Hansel A M(a)rk T D Weschler C J | | 0，，13： | 1 |
| 14 | Acoustic emission characteristics of mortar under compression 显示文摘 | WENG C C TAM M T LIN G C | 1992 | Cement and Concrete Research1992，22，4： | 1 |
| 15 | Internal governance mechanisms and firm performance in China显示文摘 | Hu H W Tam O K Tan M G S | 2010 | Asia Pacific Jour- nal of Management2010，27，： | 1 |
| 16 | Theory of isothermal currents and the direct determination of trap parameters in semiconductors and insulators containing arbitrary trap distributions显示文摘 | SIMMONS J G TAM M C | 1973 | Physical Review B1973，7，8： | 1 |
| 17 | Transfemoral insertion of a bifurcated endovascular graft for aortic aneurysm repair: the first 22 patients 显示文摘 | Wendt G Hopkinson BR | 1995 | Cardiovasc Surg1995，3，： | 1 |
| 18 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 19 | Non-structural fuzzy decision support system for evaluation of construction safety management system 显示文摘 | TAM C M TONG T K L CHIU G C V | 2002 | International Journal of Project Manage- ment2002，20，4： | 1 |
| 20 | Reaction and spectroscopic studies of sodium salt catalysts for lactic acid conversion 显示文摘 | TAM M S GUNTER G C CRACIUM R | 1997 | Ind Eng Chem Res1997，36，： | 1 |
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