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| 1 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Synthesis and anti-HIV activity of isonucleosides显示文摘 | HURYN D M SLUBOSKI B C TAM S Y | 1992 | J Med Chem1992，35，13： | 1 |
| 4 | Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas显示文摘 | Loda M Cukor B Tam SW | 1997 | Nat Med1997，3，2： | 1 |
| 5 | Determination of plasma cholesterol sulfate by LC-APCI-MS/MS in the context of pediatric autism显示文摘 | FONG B M TAM S LEUNG K S | 2013 | Talanta2013，116，： | 1 |
| 6 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 7 | Increased proteasome dependent degradation of the cyclin-de pendent kinase inhibitor p27 in aggressive colorectal carcinomas显示文摘 | Loda M Cukor B Tam SW | 1997 | Nature Med1997，3，2： | 1 |
| 8 | Ion mobility-mass spectrometry 显示文摘 | KANU A B DWIVEDI P TAM M | 2008 | J Mass Spectrom2008，43，： | 1 |
| 9 | Increased proteasomedependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas 显示文摘 | Loda M Cukor B Tam S W | 1997 | Nat Med1997，3，2： | 1 |
| 10 | Muscle apoptosis is induced in pressure-induced deep tissue injury显示文摘 | Siu P M Tam E W Teng B T | 2009 | J Appl Physiol2009，107，4： | 1 |
| 11 | Increased protesasome-depedent degration of the cyclin-depedent kinase inhibitor P27 in aggressive colorectal carcinomas显示文摘 | Loda M Cukor B Tam SW | 1997 | Nat Med1997，3，： | 1 |
| 12 | Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas显示文摘 | Loda M Cukor B Tam S W | 1997 | Nat Med1997，3，： | 1 |
| 13 | Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas 显示文摘 | Loda M Cukor B Tam SW | 1997 | Nat Med1997，3，2： | 1 |
| 14 | Increased proteasomedependent degradation of thecyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas 显示文摘 | Loda M Cukor B Tam SW | 1997 | NatureMedicine1997，3，2： | 1 |
| 15 | Increased proteasome-dependent degradation of the cydin - dependent kinase inhibitor p27 in aggressive colorectal carcinomas 显示文摘 | LODA M CUKOR B TAM S W | 1997 | Nature Med1997，3，： | 1 |
| 16 | Characterization of rhodopsin P- 23H-Induced retinal degeneration in a xenopus laevis model of retinitis pigmentosa 显示文摘 | TAM B M MORITZ O L | 2006 | Invest Ophthalmol Vis Sci2006，47，8： | 1 |
| 17 | Endoplasmic reticulum: nutrient sensor in physiology and pathology显示文摘 | József Mandl Tamás Mészáros Gábor Bánhegyi László Hunyady Miklós Csala | 2009 | Trends in Endocrinology & Metabolism2009，，4： | 1 |
| 18 | Analysis of results from large scale hydrocarbon gas explosions显示文摘 | Shearer M J Tam V H Y Corr B | 2000 | Journal of Loss Prevention in the Process Industries2000，，13： | 1 |
| 19 | Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinoma显示文摘 | Loda M Cukor B Tam SW | 1997 | Nat Med1997，3，2： | 1 |
| 20 | Increased proteasome-dependent degradation o显示文摘 | Loda M Cukor B Tam SW | 1997 | Nat Med1997，3，2： | 1 |
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