|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells显示文摘AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC.METHODS: BMSCs were obtained from patients under-going total hip arthroplasty and ADSC from human adi-pose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver develop-ment using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differ-entiation was RT-PCR-assessed and liver-marker genes were immunohistochemically analysed. RESULTS: BMSC and ADSC exhibited a fibroblastic mor-phology that changed to a polygonal shape when cells differentiated. Expression of stem cell marker Thy1 de-creased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to in-creased liver-enriched transcription factors (C/EBPβ and HNF4α), as demonstrated by adenoviral expression vec-tors.CONCLUSION: Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation ca-pacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing. | Raquel Taléns-Visconti Ana Bonora Ramiro Jover Vicente Mirabet Francisco Carbonell José Vicente Castell María José Gómez-Lechón | 2006 | World Journal of Gastroenterology2006，12，36： | 35 |
| 2 | Treatment of membranous Budd-Chiari syndrome: analysis of 480 cases显示文摘BACKGROUND: Budd-Chiari syndrome (BCS) presents a kind of disease resulted from the occlusion of hepatic vein and/or the intrahepatic inferior vena cava. Its different pathological types were proposed. According to our expe- rience , the membranous type takes a large part of it, and we tried to explore the best treatment of membranous BCS through the analysis of 480 cases retrospectively. METHOD: The operative results of 480 patients with mem- branous BCS were analysed retrospectively. RESULTS: Patients after Kimura’s finger rupture, inter- ventional treatment and membrane resection were followed up with rates of 84.62%, 86.55%, and 87.37%, respective- ly. The effective rates of the three methods were 61.4%, 91.7%, and 90.4%, respectively, and the recurrence rates of the disease after the 3 procedures were 38.6%, 8.3% and 9.6%, respectively. The long-term effects of interventional treatment and resection were significantly better than those of Kimura’ s finger rupture (P <0.05). CONCLUSION: Balloon dilatation is the choice for mem- branous BCS. Patients with extensive lesion, thick mem- brane or recurrence after percutaneous transhepatic angio- graphy should undergo membrane resection. | Pei-Qin Xu and Xiao-Wei Dang Zhengzhou, China Department of General Surgery, First A ffiliated Hospi- tal of Zhengzhou University, Zhengzhou 450052 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 3 |
| 3 | How to Construct Polar Code显示文摘 | TAL I VARDY A | 2013 | IEEE Transactions on Information Theory2013，59，10： | 1 |
| 4 | The effects of salt stress on lipid peroxidation and antioxidants in the leaf of the cultivated tomato and its wild salt-tolerant relative Lycopersicon pennellii显示文摘 | Shalata A Tal M | 1998 | Physiologia Plantarum1998，104，： | 1 |
| 5 | Efficacy of beta-blockers in infantile capil- lary haemangiomas: the physiopathological significance and therapeutic consequences 显示文摘 | Loauto-Labrbze C Tal'eb A | 2008 | Ann Dermatol Venereol2008，135，12： | 1 |
| 6 | Context-aware sali- ency detection显示文摘 | Goferman S Zelnik-Manor L Tal A | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，10： | 1 |
| 7 | Context-aware saliency detection显示文摘 | Goferman S Zelnik-Manor L Tal A | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，10： | 1 |
| 8 | Significance of intraoperative ureteral evaluation at radical cystectomy for urothelial cancer显示文摘 | RAJ GV TAL R VICKERS A | | 0，，09： | 1 |
| 9 | Noise removal using fourth-order partial differential equation with applications to medical magnetic resonance images in space and time显示文摘 | Lysaker M Lundervold A Tal X C | 2003 | IEEE Transactions on Image Processing2003，12，12： | 1 |
| 10 | Activation of c-transactivation domain is essential for optimal HIF-1alpha-mediated transcriptional and angiogenic effect显示文摘 | Tal R Shaish A Bangio L | 2008 | Microvasc Res2008，76，1： | 1 |
| 11 | A Fast Triangle to Triangle Intersection Test for Collision Detection显示文摘 | Tropp O Tal A Shoshone I | 2006 | Computer Animation and Virtual Worlds2006，17，5： | 1 |
| 12 | Nebulised 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis显示文摘 | Mandelberg A Tal G Witzling M | 2003 | Chest2003，123，4： | 1 |
| 13 | A brief review ondiagnosis of foot-and-mouth disease of Livestock: Cconventionalto molecular tools显示文摘 | LONGJAM Nr DEB R SARMAH A K e tal | 2011 | Vet Med Int2011，，： | 1 |
| 14 | Desamethasone and salbuta mol in the treatme-mof acule wheezing in infants显示文摘 | Tal A Bavilskic Yohai D | 1983 | Pediatrics1983，71，： | 1 |
| 15 | Hierarchical mesh decomposition using fuzzyciusteringand cuts显示文摘 | Katz S Tal A | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 16 | Montelukast for children with obstructive sleep apnea: a double-blind, placebo-controlled study 显示文摘 | Goldbart AD Greenberg-Dotan S Tal A | 2012 | Pediatrics2012，130，3： | 1 |
| 17 | Multilevel sensitive reconstruction of polyhedral surfaces from parallel slice 显示文摘 | Barequet G Shapiro D Tal A | 2000 | The Visual Comput- er2000，16，： | 1 |
| 18 | Application of a pro-inflammatory agent to the orbital portion of the rat infraorbital nerve induces changes indicative of ongoing trigeminal pain显示文摘 | Benoliel R Wilensky A Tal M | 2002 | Pain2002，99，3： | 1 |
| 19 | Numerical study of hemodynamics and wall mechanics in distal end to side anastomoses of bypass grafts显示文摘 | Leuprecht A Perktold K Prosi M e tal | 2002 | Biomeeh2002，35，： | 1 |
| 20 | Deferred, self-organizing BSP trees 显示文摘 | Ar S Montag G Tal A | 2002 | Computer Graphics Forum2002，21，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员