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| 1 | Metabolomic and elemental profiling of blood serum in bladder cancer显示文摘Bladder cancer(BC)is one of the most frequently diagnosed types of urinary cancer.Despite advances in treatment methods,no specific biomarkers are currently in use.Targeted and untargeted profiling of metabolites and elements of human blood serum from 100 BC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry(LDI-MS),and inductively coupled plasma optical emission spectrometry(ICP-OES).All results were subjected to multivariate statistical analysis.Four potential serum biomarkers of BC,namely,isobutyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of 0.999.Two elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICP-OES data and AUC of 0.807(in validation set).Twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated BC from NCs,as detected using LDI-MS.Five serum metabolites were found to discriminate between tumor grades and nine metabolites between tumor stages.The results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of BC. | Krzysztof Ossolinski Tomasz Ruman Valerie Copie Brian P.Tripet Leonardo B.Nogueira Katiane O.P.C.Nogueira Artur Kołodziej Aneta Płaza-Altamer Anna Ossolinska Tadeusz Ossolinski Joanna Nizioł | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 2 |
| 2 | Soluble ST2 protein in chronic heart failure is independent of traditional factors显示文摘 | Karolina W Tadeusz P Agata S | 2013 | Arch Med Sci2013，9，1： | 1 |
| 3 | Cytokines, prosta-glandins and nitric oxide in the regulation of stress- response systems显示文摘 | Gadek-Michalska A Tadeusz J Rachwalska P | 2013 | Pharmacol Rep2013，65，6： | 1 |
| 4 | A study of the variation of synchronous machine parameters due to saturation: a numerical approach显示文摘 | Escarela P Tadeusz Campero L | 2004 | Electric Power Systems Research2004，72，15： | 1 |
| 5 | On the use of ROC analysis for the optimization of abstaining classifiers显示文摘 | TADEUSZ P | 2007 | Machine Learning2007，68，2： | 1 |
| 6 | Cytokines,proatag- landins and nitric oxide in the regulation of stress-response syatems显示文摘 | Ga~dek-Michalska A Tadeusz J Rachwalska P | 2013 | Pharmacol Rep2013，65，6： | 1 |
| 7 | Purification of two lowmolecular-mass serine proteinase inhibitors from chicken liver显示文摘 | Agnieszka L Jolanta P Tadeusz W | 1999 | Journal of Chromatography1999，852，6： | 1 |
| 8 | Chronic stress adaptation of the nitric oxide synthases and IL-1βlevels in brain structures and hypothalamic-pituitary-adrenal axis activity induced by homotypic stress显示文摘 | Gadek-Michalska A Tadeusz J Rachwalska P | 2015 | J Physiol Pharmacol2015，66，3： | 1 |
| 9 | Enzyme catalyzed monohydrolysis of 2-aryl-1,3-propanediol diacetates, a study of structural effects of the aryl moiety on the enantioselectivity 显示文摘 | GIUSEPPE G ENRICA N TADEUSZ P | 1990 | Tetrahedron1990，46，20： | 1 |
| 10 | Effect of repeated restraint on homotypic stress- induced nitric oxide synthases expression in brain structures regulating HPA axis 显示文摘 | Gadek-Michalska A Tadeusz J Rachwalska P Spyrka J Bugajski J | 2012 | Pharmacological Reports2012，64，6： | 1 |
| 11 | Soluble ST2 protein in chronic heart failure is independent of traditional factors 显示文摘 | Karolina WS Tadeusz P Sakowic A | 2013 | Arch Med Sci2013，9，1： | 1 |
| 12 | Synergy in the autoxidation of S(Ⅳ) inhibited by phenolic compounds显示文摘 | Wanda P B Tadeusz B Marek U 2003 | 2003 | J Am Chem Soc2003，107，： | 1 |
| 13 | Effect of prior stress on interleukin-1β and HPA axis responses to acute stress 显示文摘 | Gadek-Michalska A Tadeusz J Rachwalska P | 2011 | Pharmacol Rep2011，63，： | 1 |
| 14 | Cytokines, prostaglandins and nitric oxide in the regulation of stress- response systems显示文摘 | Gadek-Michalska Tadeusz J Raehwalska P | 2013 | Pharmacol Rep2013，65，6： | 1 |
| 15 | The relationship betw-een the spatial distribution of fish,zooplankton and otherenvir-onmental parameters in the Solina reservoir,Poland显示文摘 | Andrzej S W Malgorzata G Tadeusz P | 2000 | Aquat Living Resour2000，13，5： | 1 |
| 16 | Pneumatic Train Brake Simulation Method显示文摘 | Tadeusz P | 2009 | Vehicle System Dynamics2009，47，12： | 1 |
| 17 | Enriched environment attenuates cell genesis in subventricular zone after focal ische mia in mice and decreases migration of newborn cells to the striatum显示文摘 | Josefine N Tadeusz W Jelena P | 2006 | Stroke2006，37，： | 1 |
| 18 | Verification of Pneumatic Railway Brake Models显示文摘 | Tadeusz P | 2010 | Vehicle System Dynamics2010，48，3： | 1 |
| 19 | Brain nitric oxide synthases in the interleukin-1(3-induced acti- vation of hypothalamic-pituitary-adrenal axis显示文摘 | Gadek-Michalska A Tadeusz J Rachwalska P | 2012 | Pharma- col Rep2012，64，6： | 1 |
| 20 | The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhib- itor TIMP2 in sarcoidosis 显示文摘 | Wojciech JP Pawe G Tadeusz P | 2011 | Med Sci Monit2011，17，10： | 1 |
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