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| 1 | Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures显示文摘Interactions with RNA-binding proteins(RBPs)are integral to RNA function and cellular regulation,and dynamically reflect specific cellular conditions.However,presently available tools for predicting RBP–RNA interactions employ RNA sequence and/or predicted RNA structures,and therefore do not capture their condition-dependent nature.Here,after profiling transcriptome-wide in vivo RNA secondary structures in seven cell types,we developed PrismNet,a deep learning tool that integrates experimental in vivo RNA structure data and RBP binding data for matched cells to accurately predict dynamic RBP binding in various cellular conditions.PrismNet results for 168 RBPs support its utility for both understanding CLIP-seq results and largely extending such interaction data to accurately analyze additional cell types.Further,PrismNet employs an“attention”strategy to computationally identify exact RBP-binding nucleotides,and we discovered enrichment among dynamic RBP-binding sites for structure-changing variants(riboSNitches),which can link genetic diseases with dysregulated RBP bindings.Our rich profiling data and deep learning-based prediction tool provide access to a previously inaccessible layer of cell-type-specific RBP–RNA interactions,with clear utility for understanding and treating human diseases. | Lei Sun Kui Xu Wenze Huang Yucheng T.Yang Pan Li Lei Tang Tuanlin Xiong Qiangfeng Cliff Zhang | 2021 | Cell Research2021，31，5： | 6 |
| 2 | Influences of residual stress and micro-deformation on microstructures and mechanical properties for Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy produced by laser powder bed fusion显示文摘Laser powder bed fusion(LPBF)yields unique advantages during the fabrication of titanium alloys.In the present work,Ti-6.5 Al-3.5 Mo-1.5 Zr-0.3 Si alloy specimens with excellent mechanical performances were fabricated by LPBF.The as-built specimens displayed relatively high strength and ductility under modest volume energy densities(VEDs),whereas they manifested high strength with low ductility under high VEDs.To investigate the key reason of this phenomenon,the specimens were designed with two VEDs ranges of 60 J/mm^(3) and 85 J/mm^(3).Special attention was paid to the influences of residual stress and micro-deformation on microstructures and mechanical properties for the first time.The results indicated that the residual stresses and relative density of the 60 J/mm^(3) range specimens were higher than that of the 85 J/mm3 range specimens.Dislocation multiplication and dislocation movement promoted by the residual stress were hindered by the initialα’phase grain boundary(prior-α’GB),leading to the formation ofα’metastable structures.The mean tensile strength and elongation of the 60 J/mm^(3) range specimens were 1248.1 MPa and 12.3%,respectively,whereas the corresponding values for the 85 J/mm^(3) range specimens were 1405.3 MPa,5.0%,respectively.During deformation,the strength and ductility of the specimens were first improved by lamellar structures generated from prior-α’phases,and then effectively enhanced by the interaction between the{10–12}twins and dislocations.However,pores significantly reduced the ductility;hence,high VED specimens with large twins and numerous large pores increased the strength and reduce the ductility. | C.C.Zhang H.L.Wei T.T.Liu L.Y.Jiang T.Yang W.H.Liao | 2021 | Journal of Materials Science & Technology2021，，16： | 3 |
| 3 | Guest Editorial for Special Issue on Blockchain for Internet-of-Things and Cyber-Physical Systems显示文摘Cyber-physical systems(CPS)are increasingly commonplace,with applications in energy,health,transportation,and many other sectors.One of the major requirements in CPS is that the interaction between cyber-world and man-made physical world(exchanging and sharing of data and information with other physical objects and systems)must be safe,especially in bi-directional communications.In particular,there is a need to suitably address security and/or privacy concerns in this human-in-the-loop CPS ecosystem.However,existing centralized architecture models in CPS,and also the more general IoT systems,have a number of associated limitations,in terms of single point of failure,data privacy,security,robustness,etc.Such limitations reinforce the importance of designing reliable,secure and privacy-preserving distributed solutions and other novel approaches,such as those based on blockchain technology due to its features(e.g.,decentralization,transparency and immutability of data).This is the focus of this special issue. | Mohammad Mehedi Hassan Giancarlo Fortino Laurence T.Yang Hai Jiang Kim-Kwang Raymond Choo Jun Jason Zhang Fei-Yue Wang | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，12： | 2 |
| 4 | Compact hybrid resonator with series and shunt resonances used in miniaturized filters and bulun filters显示文摘 | T.Yang M.Tamura T.Itoh | | 0，，02： | 1 |
| 5 | Compact hybrid resonator with series and shunt resonances used in miniaturized filters and Balun filters显示文摘 | T.Yang M.Tamure T.Itoh | | 0，，： | 1 |
| 6 | Desorption by ultrasound: Phenol on activated carbon and polymeric resin显示文摘 | Salil U.Rege Ralph T.Yang Charles A.Cain | 2004 | AIChE J2004，，7： | 1 |
| 7 | Combination iminium,enamine and copper(I) cascade catalysis:a carboannulation for the synthesis of cyclopentenes显示文摘 | T.Yang A.Ferrali L.Campbell D.J.Dixon | | 0，，： | 1 |
| 8 | 查看详情显示文摘 | T.Yang H.Chen X.Luo H.Ma | | 0，，22： | 1 |
| 9 | 查看详情显示文摘 | C.Y.Lu X.Q.Zhou O.Gühne W.B.Gao J.Zhang Z.S.Yuan A.Goebel T.Yang and J.W.Pan | | 0，，02： | 1 |
| 10 | Olefin/paraffin separations by adsorption: π‐Complexation vs. kinetic separation显示文摘 | Salil U.Rege JoelPadin Ralph T.Yang | 2004 | AIChE J2004，，4： | 1 |
| 11 | A novel compact microstrip bandpass filter using folded stepped impedance resonators显示文摘 | T.Yang R.Xu L.Xia Y.Guo | | 0，，07： | 1 |
| 12 | Vasoresponsiveness of collateral vessels in the rat hindlimb: influence of training显示文摘 | Patrick N.Colleran ZeyiLi Hsiao T.Yang M. HaroldLaughlin Ronald L.Terjung | 2010 | The Journal of Physiology2010，，8： | 1 |
| 13 | The protein tyrosine kinase inhibitor, genistein, decreases the excitability of capsaicin-sensitive neurons显示文摘AIM : One of the primary mechanisms by which neurons regulate their excitability is through of ion channel phosphorylafion. Compounds that increase noeiceptor excitability can cause hyporalgesia or allodynia whereas compounds that decrease noeiceptor excitability can be used as analgesics to relieve pain arising from inflammation or trauma. METHODS: | L.Liu FuHui T.Yang S.A.Simon | 2004 | 中国药理通讯2004，21，2： | 0 |
| 14 | Voltage-Gated Ion Channels in Nociceptors: Modulation by the cGMP-PKG pathway显示文摘AIM: Nociceptors contain a variety of ion channels that are modulated by proinflammatory mediators that may arise from tissue or nerve injury. The changes in activity of these channels, which primarily occurs through changes in intracellular pathways, may lead to the pathological states of hyperalgesia and allodynia. METHODS &RESULTS: | FuHui L.Liu T.Yang S.A.Simon | 2004 | 中国药理通讯2004，21，2： | 0 |
| 15 | Editor's note显示文摘Along with the flourishing development of information science,the Internet has realized the interconnections among the ubiquitous entities in the cyber space.It brings the unceasing expansion of the interactive data,information,knowledge,and services.The frontier information science is expected to imitate the heuristic intelligence,including human cognition(e.g.attention,emotion,and wisdom)and natural attributes(e.g.,dynamics,and self-adaptability),to promote the evolution of the information techniques.Accordingly,Cybermatics(i.e.,cyberscienceand technology)emerges as an interdisciplinary involving three main aspects:the Internet of Things(IoT),cyber,physical and social computing,and green computing and communications. | HuanSheng NING JianHua MA Laurence T.YANG WeiFeng L XinDong WU Victor C.M.LEUNG Vincenzo PIURI | 2014 | Science China(Information Sciences)2014，57，3： | 0 |
| 16 | Enhanced helium ion irradiation tolerance in a Fe-Co-Ni-Cr-Al-Ti high-entropy alloy with L12 nanoparticles显示文摘L12-strengthened high entropy alloys(HEAs)with excellent room and high-temperature mechanical prop-erties have been proposed as promising candidates as structural materials for advanced nuclear systems.However,knowledge about their radiation response is fairly limited.In the present work,a novel HEA with a high density of L12 nanoparticles was irradiated with He ion at 500°C.Transmission electron microscope(TEM)and atom probe tomography(APT)were employed to study the evolution of mi-crostructural stability and radiation-induced segregation.Similar to the single-phase FeCoNiCr HEA,the main microstructural features were numerous large faulted dislocation loops and helium bubbles.While the irradiation resistance of the present L12-strengthened HEA is much improved in terms of reduced bubble size,which could be attributed to the considerable He trapping efficiency of the coherent pre-cipitate/matrix interface and the enhanced capability of the interface for damage elimination when the matrix channel width is narrow.APT analysis revealed that an inverse-Kirkendall-mechanism-dominated radiation-induced segregation(RIS)occurs around bubbles,where a significant Co enrichment and Ni de-pletion can be clearly observed.In addition,the competing dynamics of ballistic mixing and elemental clustering that raised from the irradiation-enhanced diffusion in a highly supersaturated matrix,along with the low precipitation nucleation barrier due to the small lattice misfit,lead to a dynamical pre-cipitation dissolution and re-precipitation appears under irradiation.Such a promising phenomenon is expected to promote a potential self-healing effect and could in turn provide a sustainable irradiation tolerance over the operational lifetime of a reactor. | Y.L.Zhao F.L.Meng T.Yang J.H.Luan S.F.Liu G.M.Yeli W.T.Lin W.H.Liu X.J.Liu C.T.Liu J.J.Kai | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 17 | MICROSTRUCTURAL CHARACTERIZATION OF SPIN—VALVE MULTILAYERS BY X—RAY ANOMALYOUS DIFFRACTION TECHNIQUE显示文摘It is impossible to directly analyze the microstructure of spin-valve multilayers based on Ni,F,Cu and Mn by a conventional X-ray diffraction technique because the lattice parameter and atomic sattering factor sof them are very close.To solve this problem, we use an x-ray anomalous diffraction technique to characterize the microstructures of the [Ni80Fe20/Fe50Mn50]15 and [Ni80Fe20/Cu]15 superlattice systems.The results show that more diffraction peaks and higher internsity in the reflectivety profile are observed when the incident energy is close to the absorption edge of the lighter element(Mn) in [Ni80Fe20/Fe50Mn50]15 multilayer systems and to the absorption edge of the heavier element (Cu) in the [Ni80Fe20/Cu]15 multilayer systems.The interface and periodic structure of [Ni80F20/Fe50Mn50]15 are more perfect than that of the [Ni80Fe20/Cu]15 superlattices.The above results are disussed in this paper. | M.XU G.M.LUO T.YANG C.C.CHAI Z.H.MAI W.Y.LAI H.Y.JIANG Z.H.WU | 2001 | Beijing Synchrotron Radiation Facility2001，，2： | 0 |
| 18 | NANO-MULTILAYERS WITH HIGH PERPENDICULAR ANISOTROPY FOR MAGNETIC RECORDING显示文摘(FePt/Ag)n nano-multilayers were deposited on MgO (100) single crystal with laser ablation and then subjected to annealing. FePt L1o grains with (001) texture and thus a large perpendicular magnetic anisotropy constant Ku of the order of 106J/m3 were formed. A thick Ag layer is found to be favorable for decreasing the dispersion of the easy axis for magnetization. The measurement of time decay of magnetization gave rise to a small activation volume of the order of 10-25 m3, showing the promising of being the recording medium for future high density perpendicular recording. | T.Yang B.H.Li | 2003 | Acta Metallurgica Sinica(English Letters)2003，16，4： | 0 |
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