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| 1 | YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research显示文摘We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database(YPED) that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry(LC–MS/MS) database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring(MRM)/selective reaction monitoring(SRM) assay development. We have linked YPED's database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results. | Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn L.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.Lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry L.Miller Kenneth R.Williams | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 3 |
| 2 | 大鼠慢性高眼压诱导视神经损伤的研究显示文摘目的建立大鼠慢性高眼压模型,对其眼压、视网膜节细胞(RGCs)和视神经轴突损伤进行研究。方法对40只大鼠行慢性高眼压模型手术,分为4组:术后即刻、5 d、2周和4周,每组10只,分别测定眼压。采用全视网膜-RGCs Cresyl Violet染色,术后2周和4周对大鼠视网膜进行RGCs计数,并对视神经进行对位苯二胺(PPD)染色。对照组20只大鼠,分为2组,每组10只。结果31只大鼠眼压升高,眼压升高率为77.5%,且4周内眼压维持稳定。眼压升高2周时中心和周边RGCs分别减少11.0%和11.3%,眼压升高4周时中心和周边视网膜分别丢失RGCs达17%和24.6%,与正常对照组比较差异均有统计学意义(P<0.05);而眼压未升高的RGCs未见明显丢失,与正常对照组相比差异无统计学意义(P>0.05)。高眼压组大鼠视神经轴突在颞上方有大约5.3%损伤,球后1 mm的视神经在光镜下可以看到视神经轴突水肿和髓鞘碎屑。结论慢性高眼压动物模型是一种可以重复且有效的青光眼模型,它模拟了人类慢性眼压升高所导致的RGCs丢失和视神经的损伤。 | 汪建涛 许迅 Alfredo A.Sadun Tim T.Lam 葛坚 | 2008 | 上海交通大学学报(医学版)2008，28，6： | 3 |
| 3 | Systematic review of actual 10‐year survival following resection for hepatocellular carcinoma显示文摘 | Annelise M.Gluer NicholasCocco Jerome M.Laurence Emma S.Johnston Michael J.Hollands Henry C. C.Pleass Arthur J.Richardson Vincent W. T.Lam | 2012 | HPB2012，，5： | 1 |
| 4 | Twenty‐year audit of percutaneous liver biopsy in a major Australian teaching hospital显示文摘 | D.Van Der Poorten A.Kwok T.Lam L.Ridley D. B.Jones M. C.Ngu A. U.Lee | 2006 | Internal Medicine Journal2006，，11： | 1 |
| 5 | Twenty‐year audit of percutaneous liver biopsy in a major Australian teaching hospital显示文摘 | D.Van Der Poorten A.Kwok T.Lam L.Ridley D. B.Jones M. C.Ngu A. U.Lee | 2006 | Internal Medicine Journal2006，，11： | 1 |
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