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| 1 | 高油酸玉米突变体的诱导和遗传分析显示文摘油酸、亚油酸及饱和脂肪酸含量决定玉米油的品质。研究结果表明,利用EMS花粉诱变技术,可获得高油酸等玉米突变体。高油酸含量的遗传受部分显性主效基因控制;基因的显性方向指向增效。但是,在同一基因位点上,可能受一些微效复等位基因累加作用的影响。卡平方检验符合1对部分显性基因的遗传规律。与同类研究结果基本一致。优质油玉米育种,不仅要提高玉米的含油量,还应提高油分中的油酸含量,降低饱和脂肪酸含量,改善玉米油的品质。 | 刘治先 Allen D.Wright Ming T.Chang | 1998 | 作物学报1998，24，4： | 21 |
| 2 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 3 | Comparison of intensity‐modulated radiotherapy and 3‐dimensional conformal radiotherapy as adjuvant therapy for gastric cancer显示文摘 | A. YurikoMinn AnnieHsu TrangLa PamelaKunz George A.Fisher James M.Ford Jeffrey A.Norton BrendanVisser Karyn A.Goodman Albert C.Koong Daniel T.Chang | 2010 | Cancer2010，，16： | 1 |
| 4 | Association of core promoter/precore mutations and viral load in e antigen‐negative chronic hepatitis B patients显示文摘 | Y.‐H.Huang J.‐C.Wu T.‐T.Chang I.‐J.Sheen T.‐I.Huo P.‐C.Lee C.‐W.Su S.‐D.Lee | 2006 | Journal of Viral Hepatitis2006，，5： | 1 |
| 5 | p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis显示文摘Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is unclear.Methods: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological phenotypes.The RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease phenotypes.Results: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc^(-/-)WRN^(-/-)p53^(S/S)(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and Hnf1b.Conclusions: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis. | Haili Li Yongjin Zhang Juhua Dan Ruoyu Zhou Cui Li Rong Li Xiaoming Wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 6 | Space-heating and Water-heating Energy Demiands of the Aged in the US显示文摘 | Liao H T.Chang | | 0，，03： | 1 |
| 7 | Risk trading in trans‐boundary flood management: case study of the Dutch and German Rhine显示文摘 | C.‐T.Chang J.Leentvaar | 2008 | Journal of Flood Risk Management2008，，3： | 1 |
| 8 | Transcriptome-wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma显示文摘Dear Editor,Nasopharyngeal carcinoma(NPC)is a common malignancy in East and Southeast Asia,especially in South China.The etiology of NPC has been linked to genetic susceptibility,Epstein-Barr virus(EBV)infection,and environmental factors.Accumulated evidence including multiple genome-wide association studies(GWASs)has revealed robust genetic predisposition of NPC.However,GWAS-identified genetic variants collectively account for only 8.2%of NPC heritability[1].The underlying inherited predisposition is largely undetermined.The strongest genetic signal for NPC consistently hits the human leukocyte antigen(HLA)region on 6p21[2].However,the highly polymorphic nature and complicated long-range linkage disequilibrium(LD)in the HLA region particularly obscure the causal variants driving the association.In addition,most genetic variants located in introns or intergenic regions.The causal genes mediating genetic effects on NPC risk have rarely been ascertained by GWAS alone. | Yong-Qiao He Wen-Qiong Xue Dan-Hua Li Tong-Min Wang Zhi-Ming Mai Da-Wei Yang Chang-Mi Deng Ying Liao Wen-Li Zhang Ruo-Wen Xiao Luting Luo Hua Diao Xiating Tong Yanxia Wu Jiang-Bo Zhang Ting Zhou Xi-Zhao Li Pei-Fen Zhang Xiao-Hui Zheng Shao-Dan Zhang Ye-Zhu Hu Minzhong Tang Yuming Zheng Yonglin Cai Ellen T.Chang Zhe Zhang Guangwu Huang Su-Mei Cao Qing Liu Lin Feng Ying Sun Maria Li Lung Hans-Olov Adami Weimin Ye Tai-Hing Lam Wei-Hua Jia | 2022 | Cancer Communications2022，42，9： | 0 |
| 9 | 新一代2.0L4缸汽油机冷却系统的开发显示文摘为满足日益严格的全球燃油经济性要求,流量主动控制、缸间钻孔和快速加热等各种先进的发动机冷却技术得以应用。韩国现代汽车公司最近开发了新一代2.0L4缸汽油机,采用了几种新的冷却系统技术。从概念设计阶段到预生产阶段,总结了三维计算机辅助工程(CAE)分析在发动机冷却性能评价中的应用。对缸盖和缸体水套中的冷却液流动进行了研究,找出了最佳方案,并通过优化缸垫孔对其进行了进一步的改进。在制造首台试验发动机之前,进行了三维温度模拟,以满足工程样机阶段的开发标准。为降低发动机温度或提高生产率,在新开发的发动机上研究并实施了一些水套的设计,如快速加热的缸体水套隔板、集成EGR冷却器的缸体、集成排气歧管的缸盖等。这些设计在试验阶段呈现了良好的效果。采用了三维热流CAE分析,对各系统进行了详细的物理现象研究,并提出了解决方案。结果表明,新一代发动机的冷却系统具有足够的热稳定性。 | 武涛(译) | 2020 | 汽车与新动力2020，3，3： | 0 |
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