| 1 | 首发表现为皮肤B细胞淋巴瘤的Richter综合征不同于原发性B细胞慢性淋巴细胞白血病显示文摘Richter syndrome (RS) is a transformation to high-grade non-Hodgkin lymphoma in patients with chronic lymphocytic leukaemia (CLL). RS may develop in lymph nodes or rarely extranodally. Skin localization of RS has been described in only a few cases. We present a 77-year-old woman who developed isolated diffuse large B-cell lymphoma (LBCL) in the skin of the nose without any other symptoms of RS. The LBCL in the skin was clonally distinct from the original bone marrow CLL cells. Moreover, LBCL cells were positive for LMP-1 segment of Epstein-Barr virus and overexpressed p53 protein. The patient was successfully treated with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) and adjuvant local radiotherapy. | Robak E Góra-Tybor J Kordek R T. Robak 罗素菊 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，1： | 0 |
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