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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rev Cell Dev Biol1996，12，： | 1 |
| 3 | Peroxisome proliferator-activatied receptor, A nuclear receptor signaling pathway in lipid physiology 显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rey Cell Dev Biol1996，12，： | 1 |
| 4 | Peroxisome proliferator-activated receptors:a muclear receptor signaling pathway in lipid physiology显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rev Cell Dev Biol1996，12，： | 1 |
| 5 | Disruption of CBEB function in brain leads to neurodegeneration 显示文摘 | Mantamadiotis T Lemberger T Bleckniann SC | 2002 | Nat Genet2002，31，1： | 1 |
| 6 | Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rev Cell Dev Biol1996，12，： | 1 |
| 7 | Disruption of CREB function in brain leads to neurodegeneration 显示文摘 | Mantamadiotis T Lemberger T Bleckmann S C | 2002 | Nat Genet2002，31，11： | 1 |
| 8 | Disruption of CREB function in brain leads to neurodegeneration显示文摘 | Mantamadiotis T Lemberger T Bleckmann SC | 2002 | Nat Genet2002，31，1： | 1 |
| 9 | Peroxisome proliferatoractivated receptors:a nuclear receptor signaling pathway in lipid physiology显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rev Cell Dev Biol1996，12，： | 1 |
| 10 | Pharmacology of oxycodone:does it explain why oxycodone has become a bestselling strong opioid?显示文摘 | LEMBERG K K HEISKANEN T E KONTINEN V K | 2009 | Scandinavian Journal of Pain2009，1，： | 1 |
| 11 | De- fensins and inflammation : the role of defensins in inflamma- tory bowel disease 显示文摘 | Ramasundara M Leach S T Lemberg D A | 2009 | J Gastroenterol Hepatol2009，24，2： | 1 |
| 12 | Regulation of the peroxisome proliferators activated receplor α gene by glucocrticoids显示文摘 | Lemberger T Staels B Saludin R | 1994 | J Bid Chem1994，269，24： | 1 |
| 13 | Peroxisome prolferator-activated receptors:a nuclear receptor signaling pathway in lipid physiology Annu显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Rev Cell Dev Biol1996，12，6： | 1 |
| 14 | SLALoM: ascalable location management scheme for large mobile ad-hoc networks 显示文摘 | Cheng C T Lemberg H L Philip S J | 2002 | Wireless Communications and Networ-king Conference2002，，： | 1 |
| 15 | Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease 显示文摘 | Leach S T Messina I Lemberg D A | 2008 | Inflamm Bowel Dis2008，14，1： | 1 |
| 16 | Peroxisome proliferator - acti- vated receptors : a nuclear receptor signaling pathway in lipid physiolo- gy显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Ann Rev Cell Dev Biol1996，12，： | 1 |
| 17 | ER-based double iCre fusion protein allows partial recombination in forebrain显示文摘 | Casanova E Fehsenfeld S Lemberger T | 2002 | Genesis2002，34，4： | 1 |
| 18 | PPAR tissue distribution and interactions with other hormone-sig- naling pathways 显示文摘 | Lemberger T Braissant O Juge-Aubry C | 1996 | Ann N Y Acad Sci1996，804，： | 1 |
| 19 | Disruption of CREB function in brain leads to neurodegeneration 显示文摘 | Mantamadiotis T Lemberger T Bleckmann S C | 2002 | Nat Genet2002，31，1： | 1 |
| 20 | Peroxisome proliferator-activated receptors:a nuclear receptor signaling pathway in lipid physiology显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rev Cell Dev Biol1996，12，： | 1 |
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