|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Emerging and re -emerging infectious diseases: the hird epidemiolngic transition显示文摘 | BARRETT R KUZAWA C W MCDADE T | 1998 | Ann Rev Anthropol1998，27，： | 3 |
| 3 | Protection of goats against peste des petits ruminants with recombinant capripoxviruses expressing the fusion and haemagglutinin protein genes of rinderpest virus显示文摘 | Romero T Barrett R P Kitching C | 1995 | Vaccine1995，13，1： | 1 |
| 4 | The Epidemiology of Peste des Petits Ruminants in the Sultanate of Oman显示文摘 | TAYLOR W P ALBUSAIDY S BARRETT T | 1990 | Vet Microbiol1990，22，4： | 1 |
| 5 | Nuclear factor B inmiddle ear epithelial cells: a methodological study u- sing an ELISA显示文摘 | OVESEN T BARRETT T Q | 2003 | Acta Otolaryngol2003，123，： | 1 |
| 6 | The problem-based learning process as finding and being in flow显示文摘 | Barrett T | 2010 | Innovations in Education and Teaching International2010，47，2： | 1 |
| 7 | Database resources of the National Center for Biotechnology Information显示文摘 | Wheeler D L Barrett T Benson D A | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 8 | Rescue of rinderpest virus from cloned cDNA显示文摘 | BARON M D BARRETT T | 1997 | J Virol1997，71，2： | 1 |
| 9 | Affinity purification and characterization of Shiga-like toxin Ⅱ and production of toxin-specific monoclonal antibodies显示文摘 | DOWNES F P BARRETT T J GREEN J H | 1988 | Infect Immun1988，56，8： | 1 |
| 10 | Recent epidemiology of peste des petits ruminants virus (PPRV)显示文摘 | Dhar P Sreenivasa B P Barrett T | 2002 | Vet Microbiol2002，88，2： | 1 |
| 11 | Roles of the early genes of bacteriophage T7 in shutoff of host macromolecular synthesis 显示文摘 | McAllister W T Barrett C L | 1977 | J Virol1977，23，： | 1 |
| 12 | In-vivo metabolism of VLDL-apolipoprotein-B,-CⅢ and-E in normolipidemic subjects显示文摘 | Dinkel RE Barrett PH Demant T | | 0，，： | 1 |
| 13 | Recent epidemiology of peste des petits ruminants virus (PPRV)显示文摘 | Dhar P Sreenivasa B P Barrett T | 2002 | Vet Microbiol2002，88，2： | 1 |
| 14 | Interpretation of pulsed field gel electrophoresis patterns in foodborne disease investigations and surveillance 显示文摘 | Barrett T J Gerner-Smidt P Swaminathan B | 2006 | Foodborne Pathog Dis2006，3，1： | 1 |
| 15 | Rare-earth element and mineralogical changes in Holocene soil and stream sediment;a case study in the Wet Mountains, Colorado, U S A显示文摘 | Cullers R L Barrett T Carlson R | | 0，，3： | 1 |
| 16 | Lithogeochemical techniques using immobile elements显示文摘 | Maclean W H Barrett T J | 1993 | Journal of Geochemical Exploration1993，48，： | 1 |
| 17 | Selective interaction of JNK protein kinase isoforms with transcription factors显示文摘 | Gupta S Barrett T Whitmarsh A J | 1996 | EMBO J1996，15，11： | 1 |
| 18 | Independent humanMAP-kinase signal transduction pathways defined by MEKand MKK isoforms显示文摘 | Derijard B Raingeaud J Barrett T | 1995 | Science1995，267，68： | 1 |
| 19 | Cloning and sequence analysis of the matrixprotein gene of rinderpest virus and evidence for another bovine morbillivirus显示文摘 | Baron M D Goatley L Barrett T | 1994 | Virology1994，200，1： | 1 |
| 20 | Rescue of rinderpest virus from cloned cDNA显示文摘 | Baron M D Barrett T | 1997 | J Virol1997，71，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员