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| 1 | 免疫组化联合检测PLK1、p21和p53蛋白预测TP53基因状态:一个独立的乳腺癌预测因子显示文摘有学者认为仅用免疫组化检测p53蛋白难以准确预测TP53基因状态,本实验采用免疫组化联合检测p53和p53调节蛋白预测TP53基因突变状态的准确性。本组38例乳腺癌患者中有19例(50%)检测到TP53基因突变,其中7例TP53截短突变中有5例053免疫组化完全阴性,另外12例TP53点突变中有11例p53免疫组化强阳性。 | Watanabe G Ishida T Furuta A 魏开鹏 邱建龙 | 2015 | 临床与实验病理学杂志2015，31，11： | 7 |
| 2 | Bone Density and Mechanical Properties in Femoral Bone of Swim Loaded Aged Mice显示文摘Effects of swirnming on bone density and mechanical properties of femur were investigated in aged male and female mice. R/1 strain of senescence accelerated mouse (SAM) at eleven months old was used. Two groups of males and two groups of females each consisting of 7 mice were used. One male and one female groups were loaded with a swim regiment of 40 min a day, 5 days a week for 6 consecutive weeks. The remaining groups were used as the controls. All mice were fed with the standard diet and water ad libitum during the experiments.The results of this study indicated that (i) the hady weight was significantly (P<0.05) lower in the swimming groups than in the control groups in boh sexes. (ii) The bone density was significantly higher (P <0.05) in the swimming groups than in the control groups in boh sexes. However, there was no sighficant difference in cortical thickness index. (iii) In the mechanical properties of bone, there were no significant differences in the level of the maximum breaking force, the ultimate stress and the deformation between the swimndng and the contro groups in beth sexes. However, the elasticity of the bone of the female hoce in the swimming group was significantly higher (P<0.05) than that of the control group.These results suggest that regimented swimming for the aged mice might suppress age-associated bone loss, and the effect of exercise in the females is greater that in the males. | AKIO HOSHI HIROMI WATANABE MOMOKO CHIBA AND YUTAKA INABA (Department of Health and Physical Education, Nippon Dental University, 1-8-2 Fu-jimi, Chiyoda-ku, Tokyo, Japan )(Department of Health and Physical Education, Nippon Dental University, Fugimi, T | 1998 | Biomedical and Environmental Sciences1998，11，3： | 4 |
| 3 | Vitamin K2 selectively induced apoptosis in ovarian TYK-nμ and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol显示文摘 | Shibayama Imaau T Sakairi S Watanabe A | | J Cancer Res Clin Oncol0，，： | 2 |
| 4 | Enhancement of homogeneity of grain boundary microstructure by magnetic annealing of electrodeposited nanocrystalline nickel显示文摘 | K Harada S Tsurekawa T Watanabe G Palumbo | 2003 | Scripta Materialia2003，，5： | 2 |
| 5 | Effects of fungal pretreatment and steam explosion pretreatment on enzymatic saccharification of plant biomass显示文摘 | Sawada T Nakamura Y Kobayashi F Kuwahara M and Watanabe T | 1995 | Biotechnol Bioeng1995，48，： | 2 |
| 6 | Prognostic value of cyclin E and p53 expression in gastric carcinoma显示文摘 | Sakaguchi T Watanabe A SawadaH Yamada Y Yamashita J Matsuda M Nakajima M Miwa T Hirao T Nakano H | | 0，，： | 2 |
| 7 | Mechanism of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity显示文摘 | RASHID S WATANABE T SAKAUE T | 2003 | Clinical Biochemistry2003，36，6： | 2 |
| 8 | CYP3A activity in European American and Japanese men using midazolam as an in vivo probe显示文摘 | Tateishi T Watanabe M Nakura H | 2001 | Clin Pharmacol Ther2001，69，： | 2 |
| 9 | Prediction of contractile reserve by cyclic variation of integrated backscatter of the myocardium in patients with chronic left ventricular dysfunction显示文摘 | MURO T OTA T WATANABE H | 2001 | Heart2001，85，2： | 2 |
| 10 | Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes显示文摘 | Neugebauer S Baba T Watanabe T | | 0，，： | 2 |
| 11 | Predictability of in vivo ch-emosensitivity by in vitro MTT assay with reference to the clonogen-icassay显示文摘 | Shimoyama Y Kubota T Watanabe M | 1989 | J Surg Oncol1989，41，1： | 2 |
| 12 | Evaluating the combination of molecular prognostic factors in tumor radiosensitivity in rectal cancer 显示文摘 | Komuro Y Watanabe T Tsurita G | 2005 | Hepatogastroentcrology2005，52，63： | 1 |
| 13 | Nonspecific proteases: New approach to the isolation of adult cardiocytes显示文摘 | Bustamante JO Watanabe T McDonade TF | 1982 | Can J Physiol Pharmacol1982，60，7： | 1 |
| 14 | Comparative study on the bio- electrochemical denitrification equipped with a multi - electrode system 显示文摘 | WATANABE T KURODA M PROSNANSKY M | 2005 | Water Science & Technology2005，52，1011： | 1 |
| 15 | Diacylglycerol production in a packed bed bioreactor显示文摘 | WATANABE T SUGIURA M SATO M | 2005 | Process Biochem2005，40，2： | 1 |
| 16 | Long-term variations in dissolved silicate, nitrogen, and phosphorus flux from the Yangtze River into the East China Sea and impacts on estuarine ecosystem 显示文摘 | Li M T Xu K Q Watanabe M | 2007 | Estuar Coast Shelf S2007，71，： | 1 |
| 17 | Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hang Kong显示文摘 | Gao P Watanabe S Ito T | 1999 | J Virol1999，73，： | 1 |
| 18 | Ductility enhancement in AZ31 magnesium alloy by controlling its grain strueture显示文摘 | MUKAI T YAMANOI M WATANABE H | 2001 | Seripta Materialia2001，45，1： | 1 |
| 19 | Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates显示文摘 | Iguchi T Watanabe H Katsu Y | 2006 | Environmental Health Perspectives2006，114，1： | 1 |
| 20 | A surface plasmon resonance immunosensor for detecting a dioxin precursor using a gold binding polypeptide显示文摘 | Sob N Tokuda T Watanabe T | 2003 | Talanta2003，60，4： | 1 |
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