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147篇 您的检索式:作者名="Szyf"
    题名 作者 年代 出处 被引量
1DNA Methylation,Behavior and Early Life Adversity显示文摘终生的显型上的早物理、社会的环境的影响是众所周知的。而且,我们为相同基因变体与依赖于早年生活逆境的不同显型被联系的 geneenvironment 相互作用记录了证据。在染色体嵌入这些早年生活经验的机制是什么?DNA methylation 是用作类似的序列在一样的个人在细胞的区别和 embryogenesis 期间由获得房间类型身份的机制的 DNA 的催化 enzymatically 的修正。将这里被讨论的假设建议一样的机制在为在染色体嵌入环境经验提供机制的 DNA 之上授与环境暴露的特定的身份,因此影响长期的显型。特别地重要在包括两个的生活早是环境出生前、出生后的社会环境。Moshe Szyf 2013Journal of Genetics and Genomics2013,40,7:3
2Demethylase activity is directed by histone acetylation 显示文摘Cervoni N Szyf M 2001Biol Chcm2001,276,40:1
3Methylation and inhibition of expression of uPA by the RAS oncogene:divergence of growth control and invasion in breast cancer cells显示文摘Pakneshan P Szyf M Rabbani SA 2005Carcinogenesis2005,26,3:1
4DNA methylation signatures for breast cancer classification and prognosis 显示文摘SZYF M 2012Genome Med2012,4,3:1
5Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat显示文摘SZYF M WEAVER I C CHAMPAGNE F A 2005Frontiers in Neuroendocrinology2005,26,34:1
6Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis显示文摘Pakneshan P Szyf M Farias-Eisner R 2004J Biol Chem2004,279,31:1
7Valproate induces replication-independent active DNA demethylation显示文摘Detich N Bovenzi V Szyf M 2003J Biol Chem2003,278,27:1
8Towards a pharmacology of DNA methylation显示文摘Szyf M 2001Trends Pharmacol Sci2001,22,:1
9Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo显示文摘Ateeq B Unterberger A Szyf M 2008Neoplasia2008,10,3:1
10DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21WAF1显示文摘Milutinovic S Knox JD Szyf M 2000J Biol Chem2000,275,9:1
11Expvcssion of anlnrnse to DNA methyltransfrase, mHNA induce DNA demcthylation and inhibits tumori- genesis显示文摘Macl eod AR Szyf M 1995J Biol Chem1995,270,14:1
12Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis显示文摘Pakneshan P Szyf M Farias Eisner R 2004J Biog Ckem2004,279,31:1
13Pharmacological inhibition ot7 DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo 显示文摘Ateeq B Unterberger A Szyf M 2008Neoplasia2008,10,3:1
14Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells显示文摘CHOI AO BROWN SE SZYF M 2008J Mol Med(Berl)2008,86,3:1
15Diet and the epigenetic (re) programming of phenotypic differences in behavior显示文摘McGowan PO Meaney MJ Szyf M 0,,:1
16Epigenetic tete - a - tete : the bilateral relationship between chromatinmodifications and DNA methylation显示文摘D' ALESSIO A C SZYF M 2006Biochem Cell Biol2006,84,4:1
17Epigenetics, DNA methylation, and chromatin mod- ifying drugs 显示文摘Szyf M 2009Atom Rev Pharmacol Toxicol2009,49,:1
18DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21 WAF1/CIP1/ sdil 显示文摘Milutinovic S Knox JD Szyf M 2000J Biol Chem2000,275,9:1
19The DNA methylation machinery as a therapeutic target显示文摘Szyf M 2000Current Drug Targets2000,1,1:1
20DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21wAF1/CIP1/sdil显示文摘Milutinovic S Knox JD Szyf M 0,,:1
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