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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘 | Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 4 |
| 4 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 5 | Effect of disodium fumarate on in vitro rumen fermentation of different substrates and rumen bacterial communities as revealed by denaturing gradient gel electrophoresis analysis of 16S ribosomal DNA显示文摘 | Mao SY Zhang G Zhu WY | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 6 | X-ray CT metal artifacts reduction using wavlets: An application for imaging total hip prostheses显示文摘 | Zhao SY Robertson DD Wang G | 2000 | IEEE Transactions on Medical Imaging2000，19，12： | 1 |
| 7 | Corrosion resistant properties of polyaniline-acrylic coating on magnesium alloy 显示文摘 | Sathiyanarayanan S Syed Azim S Venkatachari G | 2006 | Applied Surface Science2006，253，4： | 1 |
| 8 | Complete septate uterus,obstructed hemivagina,and ipsilateral adnexal and renal agenesis in pregnancy显示文摘 | Kim MS Nam SY Lee G | 2014 | Obstet Gynecol Sci2014，57，4： | 1 |
| 9 | Compact optical diagnostic device for isothermal nucleic acids amplifi cation显示文摘 | LEE SY HUANG J G CHUANG T L | | 0，，： | 1 |
| 10 | Anaerobic fermentation of glycerol: A path to economic viability for the biofuels industry显示文摘 | Syed S Y Ramon G | 2007 | Curr Opin Biotechnol2007，18，3： | 1 |
| 11 | BRIT1/MCPH1 is a muhifunetional DNA damage responsive protein mediating DNA remodel-ing显示文摘 | Peng G Lin SY | 2009 | Cell Cycle2009，8，19： | 1 |
| 12 | Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenografts显示文摘 | Han SY Zhao W Sun H Zhou N Zhou F An G | 2015 | Phytomedicine2015，22，5： | 1 |
| 13 | Functional connectivity and laterality of the motor and sensory components in the volitional swallo- wing network 显示文摘 | Lowell SY Reynolds RC Chen G | 2012 | Exp Brain Res2012，219，1： | 1 |
| 14 | Effect ofnozzle geometry on the atomization and spray characteristicsof gelled-propellant simulations formed by two impingingjets显示文摘 | Fakhri Syed Lee Jong Guen G Richard A | 2010 | Atomization and Sprays2010，20，12： | 1 |
| 15 | 锐钛型钛二氧化物纳米颗粒对小鼠的影响:证据表明短时间而不是长时间的暴露会导致小鼠精子结构和功能的异常显示文摘锐钛型钛二氧化物纳米颗粒(TNPs)广泛应用在商业领域,并且存在于不同的产品中。为明确更小剂量的锐钛型钛二氧化物纳米颗粒(ATNPs)间隔一定距离进入体内到达阴囊后是否能诱导精子缺陷的发生,雄性成年小鼠持续3天腹腔内注射100%ATNP(2.5或5mg/kg),然后在注射后1周、2周、3周或5周(长时间暴露)或者是注射后24小时、48小时或120小时(短时间暴露)处死。透射电镜表明在注射后120小时收集到的阴囊脂肪组织中,附睾组织和附睾液均出现炎症反应。在注射后120小时和3周后,睾丸组织间质间隙增大。利用末端脱氧核糖核酸转移酶介导的缺口末端标记技术发现在注射后的雄鼠体内阳性(即凋亡)精子(P=0.002)和间质细胞(P=O.04)数目均显著增加。与对照组相比,短时间暴露而不是长时间暴露的附睾尾部精子鞭毛异常、过量胞浆残余(ERC)的发生率增加,精子无顶体反应的发生率增加(呈剂量依赖性)。ERC与无顶体反应是否存在相关性目前尚不清楚。与对照组相比,暴露120小时组快速运动精子数量和线粒体膜电位均显著下降(P〈0.05),同时,活性氧水平显著增加(P〈0.00001)。这些结果表明在注射后4.8天,ANTP能够引发不育的精子结构和功能的异常,并且通过氧化应激造成DNA的损伤。同时,在暴露后的10天到5周末检测到精子的异常,这表明精子的这种异常是暂时性的。 | Michelle A Smith Rowan Michael Rolands G Aravindan Soma Dash Syed I Shah Deni S Galileo Patricia A Martin-DeLeon | 2015 | Asian Journal of Andrology2015，17，2： | 1 |
| 16 | Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer 显示文摘 | Iliopoulos D Guler G Han SY | 2005 | Oncogene2005，24，9： | 1 |
| 17 | Fusobacterium nuclea- turn induces cytokine production through Toll-like-recep- tor-independent mechanism 显示文摘 | Quah SY Bergenhohz G Tan KS | 2014 | Int Endod J2014，47，6： | 1 |
| 18 | Frequency of myocardial bridges and dynamic comp ression of ep icardial coronary arteries:acomparison between computed tomography and invasive coronary angiography显示文摘 | Kim PJ Hur G Kim SY | 2009 | Circulation2009，119，10： | 1 |
| 19 | The transgression record of the Gucheng Lake in 9.6 ka B. P.显示文摘THE Gucheng Lake is located in Gaochun County, Jiangsu Province, China (31°14′36'—31°19′28'N, 118°51′34'—118°57′56'E). It lies in the southeast monsoon climate area. To study the pateoclimatic and environmental change of the lake area since Late Ice Age and clarify evolution of the southeast monsoon, a core of 20 m (GS1) was drilled at the center of | Shen, J Wang, SM Liu, SY Zhang, G | 1997 | Chinese Science Bulletin1997，42，17： | 1 |
| 20 | Oxygenated bisabolanes from Alpinia densbracteata 显示文摘 | Sy L K Brown G D | 1997 | Phytochemistry1997，45，3： | 1 |
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