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您的检索式：作者名="Syed Azizur Rahman"
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| 1 | Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review显示文摘BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal cancer.The search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic strategies.Ubiquitin-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various cancers.There have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is lacking.AIM To provide a systematic review of the studies investigating the roles and functions of USPs in CRC.METHODS We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science databases.RESULTS Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug resistance.The findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in CRC.The dysregulation of USPs in CRC contributes to drug resistance through multiple mechanisms.CONCLUSION Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC. | Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-Rahman | 2024 | World Journal of Gastrointestinal Oncology2024，16，1： | 0 |
| 2 | Experimental investigation of multiphase flow behavior in drilling annuli using high speed visualization technique显示文摘Imaging with high definition video camera is an important technique to visualize the drilling conditions and to study the physics of complex multiphase flow associated with the hole cleaning process.The main advantage of visualizing multiphase flow in a drilling annulus is that the viewer can easily distinguish fluid phases,flow patterns and thicknesses of cutting beds.In this paper the hole cleaning process which involves the transportation of cuttings through a horizontal annulus was studied.The two-phase(solid-liquid)and the three-phase(solid-liquid-gas)flow conditions involved in this kind of annular transportation were experimentally simulated and images were taken using a high definition camera.Analyzing the captured images,a number of important parameters like velocities of different phases,heights of solid beds and sizes of gas bubbles were determined.Two different techniques based on an image analysis software and MATLAB coding were used for the determinations.The results were compared to validate the image analyzing methodology.The visualization technique developed in this paper has a direct application in investigating the critical conditions required for efficient hole cleaning as well as in optimizing the mud program during both planning and operational phases of drilling.Particularly,it would be useful in predicting the cuttings transport performance,estimating solid bed height,gas bubble size,and mean velocities of bubbles/particles. | Alap Ali ZAHID Syed Raza ur REHMAN S.RUSHD Anwarul HASAN Mohammad Azizur RAHMAN | 2020 | Frontiers in Energy2020，14，3： | 0 |
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