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| 1 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 2 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 3 | Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents显示文摘Objective:To evaluate nephroprotective potential of Solarium xanthocarpum(S.xanthocarpum) fruit extract(SXE) against gentamicin(GM) induced nephrotoxicity) and renal dysfunction. Methods:Twenty-four Wistar rats were divided into four groups(n=6).Control rats that received normal saline(i.p.) and 0.5%carboxymethyl cellulose(p.o.) per day lor 8 d.Nephrotoxicity was induced in rats by intraperitoneal administration of GM(100 mg/kg/d for 8 d) and were treated with SXE(200 and 400 mg/kg/d(p.o.) for 8 d).Plasma and urine urea and creatinine,kidney weight,urine output,blood urea nitrogen,renal enzymatic and non-enzymatic antioxidants and lipid peroxidation was evaluated along with histopathological investigation in various experimental groupsof rats.Results:It was observed that the GM treatment induced significant elevation(P<0.001) in plasma and urine urea,creatinine,kidney weight,blood urea nitrogen, renal lipid peroxidation along with significant decrement(P<0.001) in urine output,renal enzymatic and non-enzymatic antioxidants.SXE 200 and 400 mg/kg treatment to GM treated rats recorded significant decrement(up to P<0.001) in plasma and mine urea and creatinine, renal lipid peroxidation along with significanl increment(up to P<0.001) in renal enzymatic and non-enzvmatic antioxidants.Histological obsenatioiis of kidney tissues too correlated with the biochemical obsenatioiis.Conclusions:These finding powerfully supports that S,xanthocarpum fruit extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM both in the biochemical and histopathological parameters and thus validates its elhnomedicinal use. | Talib Hussain Ramesh K Gupta K Sweety Bavani Eswaran M Vijayakumar Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 1 |
| 4 | Isolated breast metastasis mimicking as second primary cancer-a case report显示文摘Primary carcinoma of breast is common but breast is a rare site of metastasis and metastases from extramammary sites are even rarer.Metastasis to breast from rectal carcinoma is very unusual and till now 19 cases of breast secondaries from colorectal carcinoma have been reported in literature which include 14 cases where the primary site was colon and remaining 5 were from the rectum.Here the authors report a case of adenocarcinoma anorectum who had completed treatment and after 4 months developed a lump in her left breast which was metastatic.Metastatic lesions of breast are usually part of a widely disseminated disease but this case presented as a solitary breast metastasis which mimicked as second primary cancer of the breast. | Manjari Shah Umang Mithal Sandeep Agarwal Sweety Gupta Disha Tiwari Shashank Srinivasan Asheesh Jain Ritu Chandra | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
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