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| 1 | Diagnosis of Helicobacter pylori infection: Current options and developments显示文摘Accurate diagnosis of Helicobacter pylori(H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice,several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology,culture,rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathingtest and stool antigen test are most widely used noninvasive tests,whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection,several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori,as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes. | Yao-Kuang Wang Fu-Chen Kuo Chung-Jung Liu Meng-Chieh Wu Hsiang-Yao Shih Sophie SW Wang Jeng-Yih Wu Chao-Hung Kuo Yao-Kang Huang Deng-Chyang Wu | 2015 | World Journal of Gastroenterology2015，21，40： | 66 |
| 2 | Endonasal transsphenoidal removal of tuberculum sellae meningiomas: technical note(英文)显示文摘OBJECTIVE: Tuberculum sellae meningiomas traditionally have been removed through a transcranial approach. More recently, the sublabial transsphenoidal approach has been used to remove such tumors. Here, we describe use of the direct endonasal transsphenoidal approach for removal of suprasellar meningiomas. METHODS: Three women, aged 32, 34, and 55 years, each sought treatment for visual loss and headaches. In each patient, magnetic resonance imaging (MRI) showed a suprasellar mass causing optic chiasmal and optic nerve compression (average size, 2cm x2 cm). All three patients underwent tumor removal via an endonasal approach with | Cook SW Smith Z Kelly DF | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 3 | 急性ST段抬高型心肌梗死行急诊经皮冠状动脉介入治疗的二联和三联抗血小板治疗比较显示文摘在药物洗脱支架(DES)时代,对于急诊经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者,三联抗血小板治疗优于还是相同于二联抗血小板治疗?结论仍不明确。 | Chen KY Rha SW Li YJ 刘兵 | 2009 | 中国心血管杂志2009，14，5： | 23 |
| 4 | Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma显示文摘AIM To explore the effect and mechanism ofgastrin and its antagonists proglumide and somatostatin on coIorectal carcinoma and their clinical significance.METHODS A model of transplanted human colonic carcinoma was established from SW480cell line in gymnomouse body. The volume andweight of transplanted carcinoma was observedunder the effect of pentagatrin (PG), proglumide (PGL) and octapeptide somotostatin (SMS201-995, SMS). The cAMP content ot carcinoma cell was determined by redioimmunoassay and the DNA, protein content and cell cycle were determined by flow-cytometry. The amount of viabIe cells was determined by MTT colorimetric analysis, lP3 content was determined by radioimmunoassay, Ca2+ concentration in cell by fluorometry and PKC activity by isotopic enzymolysis. The expression of gastrin, c-myc,C-fos and rasP21 in 48 cases of colorectal carcinoma tissue was detected by the immunocytochemistry SP method. Argyrophilianucleolar organizer regions was determined withargyrophilia stain.RESULTS The volume, weight, cAMP, DNAand protein content in carcinoma cell, cellamount and proliferation index of S and G2Mphase in PG group were all significantly higher than those of control group. When PG was at theconcentration of 25 mg/ L, the amount of viablecells, lP3 content and Ca2+ concentration in celland membrane PKC activity in PG group weresigniticantly higher than those in control group;when PGL was at a concentration ot 32 mg/L,they dropped to the lowest level in PG (25 mg/L)+ PGL group, but without significant differencefrom the control group. The positive expression rate of gastrin, c-myc, c-fos and rasp21 in carcinoma tissue was 39 .6%, 54 .2%, 47. 9% and54 .2% resPectively and significantly higher than that in mucosa 3 cm and 6 cm adjacent tocarcinoma tissue and normal colorectal mucosa.The positive expression rate of gastrin of highlydifferentiated adenocarcinoma group was significantly higher than that of poorly differentiated and mucinous adenocarcinoma groups. The AgNORs count of carcinoma tissue was significantly higher than that in mucosa 3 cm and 6 cm adjacent to carcinoma tissue and normal colorectal mucosa; and the positive expression of c-myc and c-fos and the AgNORs count in gastrin-positive group was significantly higher than those in gastrin-negative group.CONCLUSION Pentagastrin has a promoting effect on the growth of transplanted human colonic carcinoma from SW480 cell line. PGL hasno obvious effect on the growth of human colonic carcinoma SW480 cell line, but couldinhibit the growth-promoting effect of PG on transplanted carcinoma. Somatostatin can not only inhibit the growth of transplanted human colonic carcinoma from SW480 cell line directlybut also depress the growth-promoting effect ofgastrin on the transplanted carcinoma. Somecolorectal carcinoma cells can produce and secrete gastrin through autocrine, highly-differentiated adenocarcinoma express the highest level gastrin. Endogenous gastrin can stimulate the cell division and proliferation of carcinoma cell and promote the growth of colorectal carcinoma regulating the expression of oncogene omyc, c-fos. Our study has provided experimental basis for the adjuvant treatment using gastrin antagonist such as PGL,somatostatin of patients with colorectalcarcinoma. | He SW Shen KQ He YJ Xie B Zhao YM | 1999 | World Journal of Gastroenterology1999，5，5： | 20 |
| 5 | 无创机械通气时单用右美托咪定持续静点镇静的经典用法对血流动力学的影响以及撤药风险显示文摘目的右美托咪定用于儿童重症监护逐渐增加,其作为单一持续镇静药物时的长期效应尚无明确研究。本研究旨在了解长时间应用右美托咪定为唯一持续镇静药物时,其对血流动力学的影响、撤药策略及戒断反应风险因素。设计回顾性病历分析。场所大型单中心四级儿科医学院。对象共纳入382例患儿;〈18岁且于PICU内无创机械通气(non—invasive ventilation,NIPPV)期间仅静点右美托咪定镇静〉24h。干预措施记录右美托咪定常规用药方法。撤药策略分为:骤停,逐渐减停及改为口服可乐定。 | Shutes BL Gee SW Sargel CL 方伯梁 钱素云 | 2018 | 中国小儿急救医学2018，25，3： | 18 |
| 6 | Dual specimens increase the diagnostic accuracy and reduce the reaction duration of rapid urease test显示文摘AIM:To evaluate the influence of multiple samplings during esophagogastr oduodenoscopy(EGD) on the accuracy of the rapid urease test,and the validity of newly developed rapid urease tests,HelicotecUT plus test and HelicotecUT test,CLO test and ProntoDry test.METHODS:A total of 355 patients undergoing EGD for dyspepsia were included.Their Helicobacter pylori(H.pylori) treatment status was either nave or eradicated.Six biopsy specimens from antrum and gastric body,respectively,were obtained during EGD.Single antral specimens and dual(antrum+body) specimens were compared.Infection status of H.pylori was evaluated by three different tests:culture,histology,and four different commercially available rapid urease tests(RUTs)-including the newly developed HelicotecUT plus test and HelicotecUT test,and established CLO test and ProntoDry test.H.pylori status was defined as positive when the culture was positive or if there were concordant positive results among histology,CLO test and ProntoDry test.RESULTS:When dual specimens were applied,sensitivity was enhanced and RUT reaction time was signif icantly reduced,regardless of their treatment status.Thirty minutes were enough to achieve an agreeable positive rate in all the RUTs.Both newly developed RUTs showed comparable sensitivity,specif icity and accuracy to the established RUTs,regardless of patient treatment status,RUT reaction duration,and EGD biopsy sites.CONCLUSION:Combination of antrum and body biopsy specimens greatly enhances the sensitivity of rapid urease test and reduces the reaction duration to 30 min. | Wen-Hung Hsu Sophie SW Wang Chiao-Yun Chen Ching-Wen Chang Jaw-Yuan Wang Yuan-Chieh Yang Deng-Chyang Wu Ming-Tsang Wu | 2010 | World Journal of Gastroenterology2010，16，23： | 13 |
| 7 | Apoptosis of neoplasm cell lines induced byhepatic peptides extracted from sucking porcine hepatocytes显示文摘 | Kong XP Zou QY Li RB Zheng PL Yang LP Jin SW | 1999 | World Journal of Gastroenterology1999，5，5： | 11 |
| 8 | 剖宫产对母乳喂养启动、持续时间和产后4个月喂养困难的影响显示文摘研究表明,母乳喂养可降低儿童期疾病发生率\成人血压和胆固醇水平以及肥胖发病率等,但是很多因素都会影响母乳喂养,其中剖宫产是最主要的影响因素之一。 | Hobbs AJ Mannion CA McDonald SW 姜珊 荫士安 杨振宇 | 2016 | 中华预防医学杂志2016，50，12： | 10 |
| 9 | Crack tip fields of piezoelectric materials under antiplane impact显示文摘THE fracture mechanics of piezoelectric materials is extensively studied under static mechanicalor electrical loads. However, the failure of practical smart structure always happens underdynamic loads, so it is urgently needed to study the fracture dynamics of piezoelectric materi-als. The dynamic Green’s functions for anisotropic piezoelectric materials were proposed byNorris. The dynamic representative formulas and the fundamental solutions were | Chen, ZT Yu, SW | 1997 | Chinese Science Bulletin1997，42，19： | 6 |
| 10 | 高效液相色谱—蒸发光谱射检测测定川贝母中主要镇咳生物活性成分西贝母碱及其在鼠体内药代动力学研究显示文摘本文利用HPLC-ELSD建立了直接分析血样中西贝母碱的分析方法,通过该法研究了小鼠的西贝母碱药代动力学等特征。 | Chan,SW 崔颖 | 2001 | 国外分析仪器技术与应用2001，，4： | 6 |
| 11 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 12 | “Anti-HBc alone” in human immunodefi ciency virus-positive and immuno-suppressed lymphoma patients显示文摘Hepatitis B virus (HBV) infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen (anti-HBc), which could produce protective antibody to hepatitis B surface antigen (anti-HBs). With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or 'anti-HBc alone'. In the context of immunodef icient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in 'anti-HBc alone' patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management. | Yu Xuan Koo Daniel SW Tan Iain BH Tan Richard Quek Miriam Tao Soon Thye Lim | 2009 | World Journal of Gastroenterology2009，15，30： | 5 |
| 13 | 死去还是生还:凋亡及其在疾病中的作用显示文摘 | Hett.,SW 陈永亮 | 1999 | 美国医学会杂志(中文版)1999，18，1： | 5 |
| 14 | Backward Propagation of Otoacoustic Emissions显示文摘Normal mammalian ears not only detect but also generate sounds. The ear-generated sounds, i.e., otoacoustic emissions (OAEs), can be measured in the external ear canal using a tiny sensitive microphone. In spite of wide applications of OAEs in diagnosis of hearing disorders and in studies of cochlear functions, the question of how the cochlea emits sounds remains unclear. The current dominating theory is that the OAE reaches the cochlear base through a backward traveling wave. However, recently published works, including experimental data on the spatial pattern of basilar membrane vibrations at the emission frequency, demonstrated only forward traveling waves and no signs of backward traveling waves. These new findings indicate that the cochlea emits sounds through cochlear fluids as compression waves rather than through the basilar membrane as backward traveling waves. This article reviews different mechanisms of the backward propagation of OAEs and summarizes recent experimental results. | HE Wenxuan,1, 2 REN Tianying,1, 21. Oregon Hearing Research Center, Department of Otolaryngology and Head & Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, NRC04, Portland, Oregon 97239 USA 2. School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710061 China | 2006 | Journal of Otology2006，1，1： | 4 |
| 15 | 文献快报(3):童年期和成年期生活压力对老年期炎症基因表达的影响显示文摘生命早期的不良经历一直潜在影响着人类的健康。童年期不良经历通过对神经内分泌功能的改变影响着功体的生理功能与内环境稳定,增加了心血管疾病、糖尿病、癌症、神经退行性疾病、关节炎等的患病风险。 | LEVINE ME COLE SW WEIR DR 苏普玉 | 2015 | 中国学校卫生2015，36，3： | 4 |
| 16 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 17 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
| 18 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 19 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 20 | Effect of polysaccharides of cassiae seeds on the intestinal microflora of piglets显示文摘 | Deng ZY Zhang JW Li J Fan YW Cao SW Huang RL Yin YL Yin, Yu-long Zhong HY Li TJ | 2007 | 中国生物学文摘2007，21，6： | 3 |
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