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1篇 您的检索式:作者名="Suzanne Paley"
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1Plant Metabolic Network 15:A resource of genome-wide metabolism databases for 126 plants and algae显示文摘To understand and engineer plant metabolism, we need a comprehensive and accurate annotation of all metabolic information across plant species. As a step towards this goal, we generated genome-scale metabolic pathway databases of 126 algal and plant genomes, ranging from model organisms to crops to medicinal plants(http://gffzz2d74b8df582c4b03spnfw6bkqqfkc6kwb.ffgz.tsg.suse.edu.cn).Of these, 104 have not been reported before.We systematically evaluated the quality of the databases, which revealed that our semi-automated validation pipeline dramatically improves the quality. We then compared the metabolic content across the 126 organisms using multiple correspondence analysis and found that Brassicaceae,Poaceae, and Chlorophyta appeared as metabolically distinct groups. To demonstrate the utility of this resource, we used recently published sorghum transcriptomics data to discover previously unreported trends of metabolism underlying drought tolerance. We also used single-cell transcriptomics data from the Arabidopsis root to infer cell typespecific metabolic pathways. This work shows the quality and quantity of our resource and demonstrates its wide-ranging utility in integrating metabolism with other areas of plant biology.Charles Hawkins Daniel Ginzburg Kangmei Zhao William Dwyer Bo Xue Angela Xu Selena Rice Benjamin Cole Suzanne Paley Peter Karp Seung Y.Rhee 2021Journal of Integrative Plant Biology2021,63,11:0
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