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| 1 | Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions显示文摘AIM: To assess the diagnostic accuracy of endoscopic ultrasound (EUS), fluid tumor markers and cytology in distinguishing benign from (pre)malignant pancreatic cystic lesions. METHODS: 46 consecutive patients, referred to a gastroenterologist and surgeon for a symptomatic or incidental pancreatic cyst, were reviewed. EUS, cytology, and carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) levels were compared with the final diagnosis, based on surgical pathology and/or imaging follow-up of at least 12 mo. Cysts were classified as benign (pseudocyst, serous cystadenoma) or malignant/ pre-malignant (mucinous cystic neoplasm). Receiver- operator characteristics (ROC) curve analysis was performed. RESULTS: The mean age was 56 years; 29% were male and median cyst diameter was 3 cm. Final outcome was obtained in 41 (89%) patients. Twenty-three (56%) of these 41 had surgical pathology. Twenty-three (56%) had benign lesions and 18 (44%) had malignant/pre- malignant lesions. Sensitivity, specificity and positive and negative predictive value of EUS alone to distinguish benign from malignant/premalignant pancreatic cystic lesions were 50%, 56%, 36% and 54% and for cytology were 71%, 96%, 92% and 85%, respectively. The corresponding values for the ROC-derived ideal cutoffswere 75%, 90%, 75%, 90% for CA 19-9 (> 37 U/mL) and 70%, 85%, 79% and 78% for CEA (> 3.1 ng/mL). Subgroup analysis of those with surgical pathology yielded almost identical performance and cutoffs. CONCLUSION: Cytology and cyst fluid tumor marker analysis is a very useful tool in distinguishing benign from (pre)malignant pancreatic cystic lesions. | Abdulrahman M Aljebreen Joseph Romagnuolo Rafael Perini Francis Sutherland | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 2 | RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family显示文摘控制基因规定为维持繁殖潜力在配偶子开发期间是重要的。在哺乳动物的精子发生的复杂过程期间,尽管有重翻译要求,男细菌房间为继续的生长和区别经历不活跃的抄写的扩大时期。因此,精子发生高度依赖基因表示的 posttranscriptional 规定的机制,由 RNA 有约束力的蛋白质(RBP ) 便于,它仍然保持富有地在整个这进程表示了。一如此的组蛋白质是 Musashi 家庭,以前在果蝇识别了睾丸细菌房间开发和成熟分裂的同样批评的管理者,并且也出现对在老鼠的精子开发和繁殖潜力重要。这评论在男细菌房间开发的范围以内描述 RBP 的角色和函数,集中于我们在精子发生的 Musashi 蛋白质的最近的知识。RBP 在房间以内利用的功能的机制在与模式的关系深入地亚 cellular 本地化和阶段特定的表示的,和意义被构画出, posttranscriptional 规定的影响也被加亮。当原来在果蝇和 Xenopus 描绘了,我们在干细胞功能和房间命运决心强调 RBP 的 Musashi 家庭的历史的角色,并且与我们微分角色的当前的理解和哺乳动物的 Musashi 蛋白质, Musashi-1 和 Musashi-2 的功能得出结论,与我们在精子发生的调查结果的一个主要焦点。这评论两个都作为男配偶子开发的主人管理者加亮 RBP 的必要贡献到 posttranscriptional 规定和 Musashi 家庭的重要性。 | Jessie M Sutherland Nicole A Siddall Gary R Hime Eileen A McLaughlin | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 3 | Exercise and adrenaline increase PGC-1 { alpha} mRNA expression in rat adipose tissue显示文摘 | SUTHERLAND L N BOMHOF M R CAPOZZI L C | 2009 | J Physiol2009，587，7： | 1 |
| 4 | Aciton spectrum for DNA damage in alfalfa lowers predicted impatct of ozone depletion显示文摘 | Quaite F E Sutherland B M Sutherland J C | 1992 | Nature1992，3，58： | 1 |
| 5 | Subunit and cofactor binding of Saccharomyces cerevisiae sulfite reductase-towards developing wine yeast with lowered ability to produce hydrogen sulfide显示文摘 | SUTHERLAND C M HENSCHKE P A LANGRIDGE P | 2003 | Aust J Grape Wine Res2003，，9： | 1 |
| 6 | Cell surface antigen CD109 is a novel member of the ct 2' maeroglobulin/C3, C4, C5 family of thioester-containing proteins 显示文摘 | Lin M Sutherland D R Horsfall W | 2002 | Blood2002，99，5： | 1 |
| 7 | Fungal bio-transformation of benzo quinoline,benzo quino-line ,and phenanthridine显示文摘 | Sutherland J B Cross E L Heinze T M | 2005 | Appl Microbiol Biotechn-ol2005，67，： | 1 |
| 8 | The nature of scour development and scour protection at offshore wind farm foundations 显示文摘 | Whitehouse Richard J S Harris John M Sutherland James | 2011 | Marine Pollution Bulletin2011，62，1： | 1 |
| 9 | MicroRNAs miR-143and miR-145 modulate cytoskeletal dynamics and responsivenessof smooth muscle cells to injury 显示文摘 | Xin M Small EM Sutherland LB | 2009 | Genes Dev2009，23，18： | 1 |
| 10 | Body mass index and phenotype in subjects with mild-to-moderate persistent asthma显示文摘 | Sutherland ER Lehman EB Teodorescu M | | 0，，： | 1 |
| 11 | Effects of depression and pain severity on satisfaction in medical outpatients : analysis of the Medical Outcomes Study显示文摘 | BAIR M J KROENKE K SUTHERLAND JM | 2007 | J Rehabil Res Dev2007，44，2： | 1 |
| 12 | Bacillus cereus is common in the environment but emetic toxin producing isolates are rare 显示文摘 | ALTAYAR M SUTHERLAND A D | 2006 | J Appl Microbiol2006，100，1： | 1 |
| 13 | One Hundred Questions of Importance to the Conservation of Global Biological Diversity 显示文摘 | SUTHERLAND W J ADAMS W M ARONSON R B | 2009 | Conservation Biology2009，23，3： | 1 |
| 14 | Schlieren visualisation and measurement of axisymmetric disturbances显示文摘 | Sutherland B R Flynn M R Onu K | 2003 | Nonlinear Processes in Geophysics2003，，10： | 1 |
| 15 | Oxida-tion of phenothiazine and phenoxazine by cunninghamel-la elegans显示文摘 | Sutherland J B Freeman J P Heinze T M | 2001 | Xenobiotica2001，31，： | 1 |
| 16 | Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease显示文摘 | Sutherland J S Adetifa I M Hill P C | 2009 | Eur J Immunol2009，39，3： | 1 |
| 17 | The use of high resolution melting (HRM) to map single nucleotide polymorphism markers linked to a covered smut resistance gene in barley 显示文摘 | Lehmensiek A Sutherland M W McNamara R B | 2008 | Theor Appl Genet2008，117，5： | 1 |
| 18 | Curtin industrial safety trial:Managerial behavior and program effectiveness 显示文摘 | Harper A C Cordery J L De Klerk N H Sevastos P Geelhoed E Gunson C Robinson L Sutherland M Osbom D Colquhoun J | 1996 | Safety Science1996，24，3： | 1 |
| 19 | Self-starting Kerr-lens mode-locked femtosecond Cr^4+: YAG and picosecond Pr^3+ : YLF solid-state lasers显示文摘 | Tong Y P Sutherland J M French P M W | 1996 | Opt Lett1996，21，9： | 1 |
| 20 | Myocardinrelated transcription factor: a controls myofibroblast activation and fibrosis in response to myocardial infarction显示文摘 | Small E M Thatcher J E Sutherland L B | 2010 | Circ Res2010，107，2： | 1 |
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