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	题名	作者	年代	出处	被引量
1	MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。	Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt	2018	Cell Research2018，28，7：	5
2	Cardiac biomarkers predict outcome after hospitalization for an acute exacerbation of chronic obstructive pulmonary disease 显示文摘	Marcun R Sustic A Brguljan PM	2012	Int J Cardiol2012，161，3：	1
3	Cardiac hiomarkers predict outcome alter hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease显示文摘	Marcun R Sustic A Brguljan PM	2012	Int J Cardiol2012，161，3：	1
4	Role of ultrasound in the aieway management of criti callyillpatients显示文摘	SUSTIC A	2007	Crit Care Med2007，35，17：	1
5	Role of ultrasound in the airway management of critically ill patients显示文摘	Sustic A	2007	Crit Care Med2007，3，：	1
6	Role of ultrasound in the airway management of critically ill patients 显示文摘	Sustic A	2007	Crit Care Med2007，35，5：	1
7	Role of ultrasound in the airway management of critically ill patients显示文摘	Sustic A		0，，5：	1
8	The proposed mechanism of action during different pain management techniques on expression of cytolytic molecule perforin in patients after colorectal cancer surgery显示文摘	S. Golubovic V. Golubovic V. Sotosek-Tokmadzic A. Sustic M. Petkovic D. Bacic I. Mrakovcic-Sutic	2010	Medical Hypotheses2010，，3：	1
9	Can ultrasound be useful for predicting the size of a left double-lmnen bronchial tube Tracheal width as measured by uhrasonography versus computed tomography 显示文摘	Sustic A Mileti D Proti A	2008	J Clin Anesth2008，20，：	1
10	Endoscopic evacuation of a hematoma resulting from strain injury of the medial head of the gastrocnemius muscle显示文摘	Cicvaric T Sustic A Miletic D	2006	J Arthroscop Relat Surg2006，22，8：	1
11	Surgical tracheostomy versus pereutaneous dilational tracheostomy in patients with anterior cervical spine fixation: preliminary report显示文摘	Sustic A Krstulovic B Eskinja N	2002	Spine2002，27，17：	1
12	Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease显示文摘	Marcun R Sustic A Brguljan PM	2012	Int J Cardiol2012，161，3：	1
13	Surgical tracheostomy versus percutaneous dilational tracheostomy in patients with anterior cervical spine fixation:preliminary report显示文摘	Sustic A Krstulovic B Eskinja N	2002	Spine2002，27，17：	1
14	Can ultrasound beuseful for predicting the size of a left double - lumen bronchial tube? Tracheal width as measured by ultrasonography versus com- puted tomography 显示文摘	SUSTIC A MILETIC D PROT1C A	2008	J Clin Anesth2008，20，4：	1
15	Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients显示文摘	Vlatka Sotosek Tokmadzic Gordana Laskarin Hana Mahmutefendic Pero Lucin Ines Mrakovcic-Sutic Zeljko Zupan Alan Sustic	2010	Injury2010，，5：	1
16	Ultrasound-guided tracheostomy: a safe method to avoid cranialmisplacement of the tracheostomy tube 显示文摘	Sustic'A KovacD Zgaljardic'Z etal	2000	Intensive Care Med2000，26，9：	1
17	The addition of a brief ultrasound examination to clinical assessment increases the a- bility to confirm placement of double - lumen endotracheal tubes 显示文摘	SUSTIC A PROTIC A CICVARIC T	2010	J Ciin Anesth2010，22，4：	1
18	Sonographic measurement of absolute and relative renal length in adults 显示文摘	Miletic D Fuckar Z Sustic A	1998	J Clin Ultrasound1998，26，4：	1
19	The proposed mechanism of action during different pain management techniques on expression of cytolytic molecule perforin in patients after colorectal cancer surgery显示文摘	S. Golubovic V. Golubovic V. Sotosek-Tokmadzic A. Sustic M. Petkovic D. Bacic I. Mrakovcic-Sutic	2010	Medical Hypotheses2010，，3：	1
20	Sonographic measurement of absolute and relative length in adults显示文摘	Miletic D Fuckar Z Sustic A	1998	J Clin Ultrasound1998，26，：	1

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