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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | Meta分析方法系统性分析腹腔镜疝修补术的选择——TEP与TAPP显示文摘腹股沟疝修补术是最常见的手术之一。一个好的疝修补术应该是操作简单、手术时间短、安全。手术结果必须是创伤小、疼痛轻以及复发率低口j。腹腔镜疝修补术和传统的开放式疝修补术(openherniarepair,OHR)相比,术后疼痛轻、对患者限制少。目前,在临床上使用最多的腹腔镜疝修补术方法分别是:经腹腔腹膜前疝修补(transabdominalpreperitoneal,TAPP)和完全腹膜外疝修补(totallyextraperitonealherniarepair,TEP)。本文运用随机对照法研究资料,分析TEP与TAPP孰优孰劣。 | Bracale U Melillo P Pignata G Di Salvo E Rovani M Merola G Pecchia L Surg Endosc 陈大伟 | 2013 | 中华疝和腹壁外科杂志(电子版)2013，7，4： | 15 |
| 3 | Design strategies and applications of biomaterials and devices for Hernia repair显示文摘Hernia repair is one of the most commonly performed surgical procedures worldwide,with a multibillion dollar global market.Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias,and despite significant progress,there is no ideal mesh for every surgery.This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias.Next,the major milestones in implant design are discussed.Commonly encountered complications and strategies to minimize these adverse effects are described,followed by a thorough description of the implant characteristics necessary for successful repair.Finally,available implants are categorized and their advantages and limitations are elucidated,including non-absorbable and absorbable(synthetic and biologically derived)prostheses,composite prostheses,and coated prostheses.This review not only summarizes the state of the art in hernia repair,but also suggests future research directions toward improved hernia repair utilizing novel materials and fabrication methods. | Surge Kalaba Ethan Gerhard Joshua S.Winder Eric M.Pauli Randy S.Haluck Jian Yang | 2016 | Bioactive Materials2016，1，1： | 8 |
| 4 | 扩大的胰十二指肠切除联合血管切除术治疗胰腺癌显示文摘目前胰腺癌的有效治疗策略是彻底地手术切除联合辅助化疗或放疗。随机临床试验报道单纯手术患者中位生存期约为18个月,手术后联合吉西他滨辅助化疗患者中位生存期约为22个月。术后同步放化疗组生存效益较单纯手术组更明显,中位生存期分别为25个月和19个月。虽然这些治疗方案在总生存率方面差异无统计学意义, | 时建 陈强谱 J Gastrointest Surg | 2010 | 中华普通外科学文献(电子版)2010，4，6： | 2 |
| 5 | Enhanced QT shortening and persistent tachycardia after generalized seizures显示文摘 | Surges R Scott CA Walker MC | 2010 | Neurology2010，74，5： | 1 |
| 6 | Temporal and spatial differences in salinity and water chemistry in SW Florida estuaries: effects of human-impacted watersheds显示文摘 | Surge D M Lohmann K C | 2002 | Estuaries2002，25，3： | 1 |
| 7 | Peri-ictal atrioventricularconduction block in a patient with a lesion in the left insula : casereport and review of the literature 显示文摘 | Surges R Scott CA Walker MC | 2009 | Epilepsy Behav2009，16，： | 1 |
| 8 | Characterization of rebound depolarization in hippocampal neurons显示文摘 | Surges R Sarvari M Staffens M | 2006 | Biochem Biophys Res Commun2006，348，4： | 1 |
| 9 | Controls on isotopic chemistry of the American oyster,Crassostrea virginica:implications for growth patterns显示文摘 | Surge D M Lohmann K C Dettman D L | 2001 | Palaeogeography Palaeoclimatology Palaeoecology2001，172，： | 1 |
| 10 | Controls on isotopic chemistry of the American oyster, Crassostrea virginica : Implications for growth patterns 显示文摘 | Surge D M Lohmann K C Dettman D L | 2001 | Palaeogeography Palaeoclimatology Palaeoecology2001，172，： | 1 |
| 11 | Pancreatic and Hepatic Abscess Secondary to Fish Bone Perforation of the Duodenum显示文摘 | Brian K. P. Goh MBBS MRCS MMed(Surg) Wei-Sean Yong MBBS FRCS Allen W. Y. Yeo MBBS FRCS | 2005 | Digestive Diseases and Sciences2005，，6： | 1 |
| 12 | Acromioclavicular Joint Reduction, Repair and reconstruction using metallic buttons-early results and complications显示文摘 | Lira YW Mbbs Mmed(Surg) Frcsed(Ortho) | 2012 | Technique Shoulder Elbow Surg2012，8，4： | 1 |
| 13 | 显示文摘 | Eun Kyoo Song Jong Keun Sean Min Cheol Kim Young-Jun Seol Seung Hun Lee Radiologic Measurement of Tibial Tuberosi- ty-Trochlear Groove ('I~F-TG) Dislance by Lower Extremity Rotational Profile Computed Tomogc'aphy in Koreans Clin Orlhop Surg | 2016 | Mar2016，8，1： | 1 |
| 14 | Looking back over skeletal diaries- High-resolution environmental reconstructions from accretionary hard parts of aquatic organisms显示文摘 | Schone B R Surge D M | 2005 | Palaeogeography Palaeoclimatology Palaeoecology2005，228，： | 1 |
| 15 | Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells显示文摘 | Surges R Freiman TM Feuerstein TJ | 2003 | Epilepsia2003，44，2： | 1 |
| 16 | Geochemical variation in microstructural shell layers of the southern quahog ( Mercenaria campechiensis) : Implications for reconstructing seasonality 显示文摘 | Surge D Walker K J | 2006 | Palaeogeography Palaeoclimatology Palaeoecology2006，237，： | 1 |
| 17 | Sclerochronology and geochemical variation in limpet shells (patella vulgata) : A new archive to reconstruct coastal sea surface temperature显示文摘 | Fenger T Surge D Schoene B | 2007 | Geochemistry Geophysics Geosystems2007，8，： | 1 |
| 18 | Hepatic resection for from gastric cancer 显示文摘 | Qiu JL Deng MG Li W synchronous hepatic metastssis Surg Oncol 2013 39: 694-700 | 2013 | Eur JSurg Oncol2013，39，： | 1 |
| 19 | Laparoscopic treatment for duct stones in the era of laparoscopy: laparoscopic duct exploration and laparoscopic hepatectomy显示文摘 | YOON YS intrahepatic intrahepatie Surg 2009 HAN HS SHIN SH | 2009 | Ann2009，249，2： | 1 |
| 20 | Prognostic value and determinants of ultraearly angiographic vasospasm after aneurysmal subarachnoid hemorrhage显示文摘 | Quresui A L Surg G Y Suri M A | 1999 | Neurosurgery1999，44，5： | 1 |
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