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| 1 | Long-term maintenance of stable copy number in the eukaryotic SMC family: origin of a vertebrate meiotic SMC1 and fate of recent segmental duplicates显示文摘Members of the Structural Maintenance of Chromosome (SMC) family have long been of interest to molecular and evolutionary biologists for their role in chromosome structural dynamics, particularly sister chro-matid cohesion, condensation, and DNA repair. SMC and related proteins are found in all major groups of living organisms and share a common structure of conserved N and C globular domains separated from the conserved hinge domain by long coiled-coil regions. In eukaryotes there are six paralogous proteins that form three het-erodimeric pairs, whereas in prokaryotes there is only one SMC protein that homodimerizes. From recently com-pleted genome sequences, we have identified SMC genes from 34 eukaryotes that have not been described in previous reports. Our phylogenetic analysis of these and previously identified SMC genes supports an origin for the vertebrate meiotic SMC1 in the most recent common ancestor since the divergence from invertebrate animals. Additionally, we have identified duplicate copies due to segmental duplications for some of the SMC paralogs in plants and yeast, mainly SMC2 and SMC6, and detected evidence that duplicates of other paralogs were lost, suggesting differential evolution for these genes. Our analysis indicates that the SMC paralogs have been stably maintained at very low copy numbers, even after segmental (genome-wide) duplications. It is possible that such low copy numbers might be selected during eukaryotic evolution, although other possibilities are not ruled out. | Alexandra SURCEL Xiaofan ZHOU Li QUAN Hong MA | 2008 | 植物分类学报2008，46，3： | 2 |
| 2 | Low CD4/CD8 T lymphocyte ratio in acute myocardialinfarction显示文摘 | SYRJALA H SURCEL H M ILONEN J | 1991 | Olin Exp Immunol1991，83，5： | 1 |
| 3 | Low CD4/CD8 T lymphocyte ratio in acute myocardial infarction 显示文摘 | Syrjal H Surcel H M Ilonen J | 1991 | Clin Exp Immunol1991，83，2： | 1 |
| 4 | Low CD4+/CD8+ lymphocyte ratio in acute myocardial infarction显示文摘 | SYRJALA H SURCEL HM ILONEN J | 1991 | Clin Exp Immunol1991，83，： | 1 |
| 5 | Regulatory T cells and TH1/3M2 cytokines as immunodiagnosis keys in systemic autoiranune diseses显示文摘 | Ursaciuc C Surcel M Cio taru D | 2010 | Roum Arch Microbiol Immunol2010，69，2： | 1 |
| 6 | Low CD4^+/CD8^+ lymphocyte ratio in acute myocarvial infarction显示文摘 | Syrjala H Surcel HM ilonen J | 1991 | Clin Exp Immunol1991，83，： | 1 |
| 7 | LowCD4^+/CD8^+ lymphocyte rato in acute myocardial infarction显示文摘 | Syrjala H Surcel H M Ilonen J | 1991 | Clinic Experiment Immunol1991，83，： | 1 |
| 8 | Low CD4/CD8 lymphocyte ratio in acte myocardial infection显示文摘 | Syrijala H Surcel HM llonen J | 1991 | Clin Exp immunol1991，83，： | 1 |
| 9 | Th1/ Th2 profiles in tuberculosis,based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens显示文摘 | Surcel H M Troye-Blomberg M Paulie S | 1994 | Immunology1994，81，2： | 1 |
| 10 | Low CD4/CD8 Lymphocyte ratio in acute myocardial infection显示文摘 | Syrijala H Surcel H M Llonen J | 1991 | Clin Exp Immunol1991，83，： | 1 |
| 11 | LowCD4/CD8 lymphocyte tatio in acute myocardial infectiono 显示文摘 | Syrjala H Surcel HM Lonen J | 1991 | Clin Exp Immunol1991，83，： | 1 |
| 12 | Chlamydia pneumoniae inhibits apoptosis in human epithelial and monocyte cell lines 显示文摘 | Airenne S Surcel HM Tuukkanen J | 2002 | Scand J Immunol2002，55，4： | 1 |
| 13 | C-reactive protein and erythrocyte sedimentation rate in differential diagnosis between infection and neoplastic fever in patients with solid tumours and lymphomas显示文摘 | Kallio R Bloigu A Surcel HM | 2001 | Support Care Cancer2001，9，2： | 1 |
| 14 | Chlamydia pneumoniae infection in human monocyets 显示文摘 | Airenne S Surcel HM Alakarppa H | 1999 | Infect Immun1999，67，2： | 1 |
| 15 | Management of small renal masses-update 2011显示文摘 | Surcel C Mirvald C Gingu C | | 0，，02： | 1 |
| 16 | Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm 显示文摘 | Juvonen J Surcel H M Satta J | 2007 | Arterloscler Thromb Vase Biol2007，17，11： | 1 |
| 17 | Prediction ruption by testing V,Vlikorkala of placental for C-reactive! protein and chlamydial antibod- levels in early pregnancy显示文摘 | A O ab TikkanenM Surcel H-M Bloigu Nuuti laM Hiilesmaa | 2008 | BJOGt2008，115，： | 1 |
| 18 | Low CIM/CD8 T lympho- cyte ratio in acute myocardial infarction 显示文摘 | Syrijal/i H Surcel HM Ilonen J | 1991 | Clin Exp Im- munol1991，83，2： | 1 |
| 19 | Low CD4+/CD8+ lymphocyte ratio in acutemyocardial infection显示文摘 | Surcel HM ILonen J | 1991 | Clin Exp Immunol1991，83，： | 1 |
| 20 | Low CD4/CD8 lym- phocyteratio in acute myocardial infection显示文摘 | Syrijala H Surcel H M Ilonen J | 1991 | Clin Exp Immunol1991，83，： | 1 |
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