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| 1 | Henoch-Schonlein purpura from vasculitis to intestinal perforation: A case report and literature review显示文摘Henoch-Sch?nlein purpura(HSP) is generally a selflimited vasculitis disease and has a good prognosis. We report a 4-year-old Thai boy who presented with palpable purpura, abdominal colicky pain, seizure, and eventually developed intestinal ischemia and perforation despite adequate treatment, including corticosteroid and intravenous immunoglobulin therapy. Imaging modalities, including ultrasonography and contrastenhanced computed tomography, could not detect intestinal ischemia prior to perforation. In this patient, we also postulated that vasculitis-induced mucosal ischemia was a cause of the ulcer, leading to intestinal perforation, and high-dose corticosteroid could have been a contributing factor since the histopathology revealed depletion of lymphoid follicles. Intestinal perforation in HSP is rare, but life-threatening. Close monitoring and thorough clinical evaluation are essential to detect bowel ischemia before perforation, particularly in HSP patients who have hematochezia, persistent localized abdominal tenderness and guarding. In highly suspicious cases, exploratory laparotomy may be needed for the definite diagnosis and prevention of further complications. | Butsabong Lerkvaleekul Suporn Treepongkaruna Pawaree Saisawat Pornsri Thanachatchairattana Napat Angkathunyakul Nichanan Ruangwattanapaisarn Soamarat Vilaiyuk | 2016 | World Journal of Gastroenterology2016，22，26： | 6 |
| 2 | Novel ABCB11 mutations in a Thai infant with progressive familial intrahepatic cholestasis显示文摘Progressive familial intrahepatic cholestasis(PFIC) type 2 is caused by mutations in ABCB11,which encodes bile salt export pump(BSEP).We report a Thai female infant who presented with progressive cholestatic jaundice since 1 mo of age,with normal serumγ-glutamyltransferase.Immunohistochemical staining of the liver did not demonstrate BSEP along the canaliculi,while multidrug resistance protein 3 was expressed adequately.Novel mutations in ABCB11,a four-nucleotide deletion in exon 3,c.90_93delGAAA,and a single-nucleotide insertion in exon 5,c.249_250insT, were identified,with confirmation in her parents. These mutations were predicted to lead to synthesis of truncated forms of BSEP.Immunostaining and mutation analysis thus established the diagnosis of PFIC type 2. | Suporn Treepongkaruna Amornphun Gaensan Paneeya Pienvichit Ondrej Luksan AS Knisely Pattana Sornmayura Milan Jirsa | 2009 | World Journal of Gastroenterology2009，15，34： | 3 |
| 3 | Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction:A case report and literature review显示文摘Visceral myopathy is one of the causes of chronic intestinal pseudo-obstruction. Most cases pathologically reveal degenerative changes of myocytes or muscularis propia atrophy and fibrosis. Abnormal layering of muscularis propria is extremely rare. We report a case of a 9-mo-old Thai male baby who presented with chronic intestinal pseudo-obstruction. Histologic findings showed abnormal layering of small intestinal muscularis propria with an additional oblique layer and aberrant muscularization in serosa. The patient also had a short small bowel without malrotation, brachydactyly,and absence of the 2nd to 4th middle phalanges of both hands. The patient was treated with cisapride and combined parenteral and enteral nutritional support.He had gradual clinical improvement and gained body weight. Subsequently, the parenteral nutrition was discontinued. The previously reported cases are reviewed and discussed. | Napat Angkathunyakul Suporn Treepongkaruna Sani Molagool Nichanan Ruangwattanapaisarn | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 4 | Myelodysplastic syndromes in Thailand: a retrospective pathologic and clinical analysis of 117 cases显示文摘 | Tanin Intragumtornchai Wichai Prayoonwiwat Daratana Swasdikul Nipha Suwanwela Boonsom Chaimongkol Saengsuree Jootar Kanchana Chansung Suporn Chancharunee Apichai Leelasiri Yataro Yoshida | 1998 | Leukemia Research1998，，： | 1 |
| 5 | Pulmonary arterial hypertension in previously splenectomized patients with β-Thalassemic disorders显示文摘 | Vichai Atichartakarn Khanchit Likittanasombat Suporn Chuncharunee Pakorn Chandanamattha Surapon Worapongpaiboon Pantep Angchaisuksiri Katcharin Aryurachai | 2003 | International Journal of Hematology2003，，2： | 1 |
| 6 | Thermostable mannose-binding lectin from Dendrobium findleyanum with activities dependent on sulfhydryl content显示文摘甘露糖绑定 lectin 从 Dendrobium (D.) findleyanum 被净化假灯泡使用 mannan-agarose 列层析。在与 8%-20% 压克力酰胺的一个连续坡度在 SDS 页上面对 SDS 加热与或没有 2-mercaptoethanol 以后,净化的 lectin 与 14.5 kDa 的一个分子的团给一个仅仅蛋白质乐队看了。没有加热,二个乐队在 14.5 kDa 和 53.7 kDa 的位置在胶化上被看见,但是 53.7 kDa 蛋白质的更高的数量面对 2-mercaptoethanol 被观察。两蛋白质乐队 byliquidchromatography-tandemmassspectrometry 的蛋白质鉴定从 D 显示出与一位 lectin 先锋的部分相同的三肽碎片。officinale;lectin 被称为 D。findleyanum 凝集素(DFA ) 。用土著人的各种各样的集中 -- 页和弗格森阴谋,一个仅仅蛋白质乐队揭示了 56.2 kDa 的一个分子的团,在 DFA 显示四 14.5 个 kDa 多肽子单元。等电位的集中表明 DFA 与 5.18,4.87 和 4.72 的一个等电位的点有三种 conformational 形式,而 2-mercaptoethanol-treated DFA 与 5.18 的一个等电位的点给仅仅一个乐队看了。DFA 用稳固阶段的方法向甘露糖展出了特性。有约束力的活动,抗真菌的活动和 DFA 的红血球凝聚活动没被热影响,但是被免费 sulfhydryl 组增加。 | Runglawan Sudmoon Nison Sattayasai Wandee Bunyatratchata Arunrat Chaveerach Suporn Nuchadomrong | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 1 |
| 7 | Multi-probe Real Time PCR Identification of Four Common Can- dida Species in Blood Culture Broth显示文摘 | Suporn Foongladda Nanthanida Mongkol Pornphan Petlum | 2014 | Mycopathologia2014，177，： | 1 |
| 8 | Effective Aeromonas specific monoclonal antibody for immunodiagnosis显示文摘Objective: To identify the monoclonal antibody specific to Aeromonas spp., a Gram negative bacteria causing gastroenteritis and wound infection. Methods: The monoclone, namely 88 F2-3 F4, was produced from hybridoma technology. The specificity of antibody secreted from 88 F2-3 F4 was tested against other Gram negative bacteria frequently found in gastrointestinal tract. Then the antibody was used for searching Aeromonas antigens in artificial seeded rectal swab cultures by dot-blot enzyme linked immunosorbent assay. Results: 88 F2-3 F4 produced an antibody that recognized an antigen with a molecular mass of 8.5 k Da in all 123 isolates of the seven Aeromonas species tested, but recognized no epitope of any other Gram-negative bacterium typically found in the gastrointestinal tract. A dot-blot enzyme linked immunosorbent assay based on this antibody showed 86.49% sensitivity and 92.13% specificity. Conclusions: 88 F2-3 F4 monoclonal antibody could react with all Aeromonas isolates, but not other Gram negative bacteria, therefore it should be a useful tool for the detection of Aeromonas antigen in clinical and environmental samples. | Yuvadee Mahakunkijcharoen Chakrit Hirunpetcharat Sunisa Malijunbua Watcharamat Muangkaew Suporn Paksanont | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，1： | 0 |
| 9 | Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multicentre registry network显示文摘BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease(PIBD).AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform.METHODS Clinical,endoscopic and radiologic data at diagnosis from the registry were extracted between 1^(st) January 1995 to 31^(st) December 2019.Disease phenotypic characteristics were classified as per the Paris classification system.RESULTS There was a distinct rise in new PIBD cases:Nearly half(48.6%)of the cohort was diagnosed in the most recent 5 years(2015-2019).The ratio of Crohn’s disease(CD):Ulcerative colitis(UC):IBDUnclassified was 55.9%:38.3%:5.8%.The mean age was 9.07 years with a high proportion of very early onset IBD(VEO-IBD)(29.3%)and EO-IBD(52.7%).An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort(6.8%-9.0%Indians in census).Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease(P=0.003).CD patients presented with significantly more constitutional symptoms(fever,anorexia,malaise/fatigue and muscle-wasting)than UC and higher inflammatory indices(higher C-reactive protein and lower albumin levels).CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity.South Asian CD patients were more likely to have symptomatic perianal disease. | James Guoxian Huang Yoko Kin Yoke Wong Kee Seang Chew Pornthep Tanpowpong Karen Sophia Calixto Mercado Almida Reodica Shaman Rajindrajith Kai-Chi Chang Yen-Hsuan Ni Suporn Treepongkaruna Way-Seah Lee Marion Margaret Aw | 2022 | World Journal of Gastroenterology2022，28，17： | 0 |
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