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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | The Structure and Formation Mechanism of a Sea Fog Event over the Yellow Sea显示文摘In this paper, a heavy sea fog event occurring over the Yellow Sea on 11 April 2004 was investigated based upon observational and modeling analyses. From the observational analyses, this sea fog event is a typical advection cooling case. Sea surface temperature(SST) and specific humidity(SH) show strong gradients from south to north, in which warm water is located in the south and consequently, moisture is larger in the south than in the north due to evaporation processes. After fog formation, evaporation process provides more moisture into the air and further contributes to fog evolution. The sea fog event was reproduced by the Regional Atmospheric Modeling System(RAMS) reasonably. The roles of important physical processes such as radiation, turbulence as well as atmospheric stratification in sea fog's structure and its formation mechanisms were analyzed using the model results. The roles of long wave radiation cooling, turbulence as well as atmospheric stratification were analyzed based on the modeling results. It is found that the long wave radiative cooling at the fog top plays an important role in cooling down the fog layer through turbulence mixing. The fog top cooling can overpower warming from the surface. Sea fog develops upward with the aid of turbulence. The buoyancy term, i.e., the unstable layer, contributes to the generation of TKE in the fog region. However, the temperature inversion layer prevents fog from growing upward. | GUO Jingtian LI Pengyuan FU Gang ZHANG Wei GAO Shanhong ZHANG Suping | 2015 | Journal of Ocean University of China2015，14，1： | 4 |
| 3 | 中国南亚热带土壤易分解有机碳和水稳性团聚体对造林的响应显示文摘造林被认为可以提高土壤碳稳定性并促进土壤碳累积。然而,实验结果差异很大,造林在提高土壤碳稳定性方面的作用仍存在争议。因此,在森林生态系统中不同土壤碳库对造林如何响应目前尚不清楚。基于此,本文对亚热带地区的尾叶桉林(Eucalyptus urophylla)、厚荚相思林(Acacia crassicarpa)、红锥林(Castanopsis hystrix)、10树种混交林和自然恢复草坡等5种不同林型的土壤碳组分进行了研究,评估其不同土层(0–10、10–20、20–40和40–60 cm)中的土壤易分解有机碳(容易被高锰酸钾氧化的有机碳ROC和土壤可溶性有机碳DOC)及土壤团聚体相关的碳对造林的响应。实验结果表明,造林(与自然恢复草坡比较)和林型并没有显著影响土壤ROC浓度,而自然恢复草坡土壤的DOC浓度在4个土层中均最高。0–10 cm土层中各径级的土壤团聚体其碳(C)浓度均是红锥林最高。此外,在任一土层中,林型对不同径级土壤水稳性团聚体比例的影响均不显著。但是土壤深度显著改变土壤团聚体的分布,0–20 cm土层主要为>0.25 mm粒径的团聚体,20–60 cm土层则是0.053–2 mm粒径的团聚体占主导。这些结果显示造林和林型影响土壤DOC和团聚体C,而且它们相比于ROC对造林的响应更为敏感。研究发现,与自然恢复相比,人工林降低了土壤DOC浓度,暗示它可能会减少土壤C的淋溶损失。此外,红锥林能够通过物理保护提高表土层中土壤碳的稳定性。本研究为关注土壤碳汇功能时的中国南亚热带地区造林树种选择提供了有价值的信息。 | Yuanqi Chen Yu Zhang Shiqin Yu Feng Li Suping Liu Lixia Zhou Shenglei Fu | 2021 | Journal of Plant Ecology2021，14，2： | 2 |
| 4 | Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation显示文摘Stigmasterol is a plant sterol with anti-apoptotic,anti-oxidative and anti-inflammatory effect through multiple mechanisms.In this study,we further assessed whether it exerts protective effect on human brain microvessel endothelial cells(HBMECs)against ischemia-reperfusion injury and explored the underlying mechanisms.HBMECs were used to establish an in vitro oxygen and glucose deprivation/reperfusion(OGD/R)model,while a middle cerebral artery occlusion(MCAO)model of rats were constructed.The interaction between stigmasterol and EPHA2 was detected by surface plasmon resonance(SPR)and cellular thermal shift assay(CETSA).The results showed that 10μmol·L−1 stigmasterol significantly protected cell viability,alleviated the loss of tight junction proteins and attenuated the blood-brain barrier(BBB)damage induced by OGD/R in the in vitro model.Subsequent molecular docking showed that stigmasterol might interact with EPHA2 at multiple sites,including T692,a critical gatekeep residue of this receptor.Exogenous ephrin-A1(an EPHA2 ligand)exacerbated OGD/R-induced EPHA2 phosphorylation at S897,facilitated ZO-1/claudin-5 loss,and promoted BBB leakage in vitro,which were significantly attenuated after stigmasterol treatment.The rat MCAO model confirmed these protective effects in vivo.In summary,these findings suggest that stigmasterol protects HBMECs against ischemia-reperfusion injury by maintaining cell viability,reducing the loss of tight junction proteins,and attenuating the BBB damage.These protective effects are at least meditated by its interaction with EPHA2 and inhibitory effect on EPHA2 phosphorylation. | LI Suping XU Fei YU Liang YU Qian YU Nengwei FU Jing | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 1 |
| 5 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 6 | Borehole casing failure analysis in unconsolidated formations:A ease study显示文摘 | Suping Peng Jitong Fu Jincai Zhang | 2007 | Journal of Petroleum Science and Engineering2007，59，34： | 1 |
| 7 | Borehole casing failure analysis in unconsolidated formations: A case study显示文摘 | Peng Suping Fu Jitong Zhang Jincai | 2007 | Journal of Petroleum Science and Engineering2007，59，3： | 1 |
| 8 | Efficient harvesting of green microalgae cells by magnetic flocculated Fe_(3)O_(4)nanoparticles combined with chitosan显示文摘Microalgae harvesting remains a challenging step in microalgae industrialization,thereby provoking the necessity to explore sustainable and economically feasible approaches.This research investigated the use of magnetic flocculated nanoparticles in the harvesting of the common microalgae Chlorella pyrenoidosa and Scenedesmus obliquus.The results showed that magnetic flocculated nanoparticles efficiently adsorbed negatively charged microalgae cells,and a magnetic field could adsorb the magnetic flocculated nanoparticles,thereby harvesting the microalgae cells.Harvesting efficiency was remarkably increased at the optimum magnetic field strength of 0.5 T with the magnetic flocculated nanoparticles at 0.738 g/L,and microalgae broth at pH 9.0,whereas the recovery rates of both C.pyrenoidosa and S.obliquus were around 97%and the sedimentation speed of both was above 2.63 cm/min.This study exemplified the magnetic flocculated nanoparticles-based approach to effectively harvest the microalgae cells. | Sifen Liu Suping Fu Zhongjie Wen Xiang Wang Tianjiu Jiang Hongye Li | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 9 | Experiments and Analysis of the Hydraulic Fracture Propagation Behaviors of the Granite with Structural Planes in the Gonghe Basin显示文摘Hydraulic fracture(HF) propagation behavior is significant when building enhanced geothermal systems(EGS). HF geometry is closely related to the structural planes(SPs) in hot dry rock(HDR), such as natural fractures(NFs), quartz veins(QVs) and lithologic interfaces(LIs). However, the HF behaviors in HDR have not been well understood, especially the influence of multiple SPs on the HF geometry. To clarify this mechanism, several groups of physical simulation experiments of hydraulic fracturing were conducted to investigate the intersection relationship between the HFs and the SPs. Results show that the HF geometry shows great differences when intersecting with different SPs. In summary, the HF geometry displays four basic patterns, namely, propagation along the SPs, branching, capture, penetration/non-dilation. The fluctuation degree of the pressure-time curve and the HF complexity show a positive correlation. The cementing strength of the SP and their different mechanical properties from rock matrix influence the HF behaviors significantly. Therefore, the HF shows diverse geometries when intersecting with the NFs and LIs, while propagating along the QV when intersecting with it. For the complex networks, it is favorable for the HF to penetrate through and dilate several SPs, rather than simply cross or propagate along the SP. | XIE Jingyu LI Lei WEN Dongguang PENG Suping ZHENG Jing FU Guoqiang | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 0 |
| 10 | Stress regulation of photosynthetic system of Phaeocystis globosa and their hemolytic activity显示文摘Blooms of Phaeocystis globosa have been reported accountable for massive fi sh mortality worldwide.The toxigenic mechanisms of P.globosa,however,remain largely unclear due to the multiple structures and/or synergistic or antagonistic ef fects of hemolytic compounds.External stressors could lead to the regulation of photoprotective or antioxidative defense system,as well as the potential hemolytic activity.Therefore,the light-induced photosynthetic system,including the accessory photosynthetic growth,the relative electron transfer rate(ETR),photosynthetic e ffi ciency(F_(v)/F_(m)),quantum yield of photosystem II(Yield),together with the hemolytic activity of P.globosa were investigated under variable environmental conditions in the present study.Results confirmed that hemolytic activity of P.globosa was initiated by the light,but inhibited by low temperature(16℃),high light intensity(>100μmol/(m^(2)·s)),and iron-limited conditions.Interestingly,the hemolytic activity was not impacted by photosynthetic electron inhibitors(Diuron,atrazine,paraquat,and dibromothymoquinone),which signifi cantly inhibited the photosynthetic activity of P.globosa.The correlated response of hemolytic and photosynthetic activity of P.globosa under those environmental factors suggested that the hemolytic compounds of P.globosa would be involved in the photosynthetic process but not in the electron transfer chain of P.globosa. | Ni WU Suping FU Xinru SONG Mengmeng TONG Tianjiu JIANG | 2022 | Journal of Oceanology and Limnology2022，40，6： | 0 |
| 11 | Study on Effect of Two Different Metallic Materials Transitional Flanges on Vacuum of Beamline显示文摘The vaccum degree of 100MeV high intensity cyclotron beam line directly affects the beam quality and transmission efficiency.Because the original molecular pump of 100MeV high intensity cyclotron beam line is frequently fault,it needed to be replaced and repaired.During | ZHU Xiaofeng ZHANG Suping LYU Yinlong PAN Gaofeng FU Zhenhui | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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