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| 1 | Human vitamin K-dependent Gas 6, gene structure, allelic variation, and association with stroke显示文摘 | Munoz X Sumoy L Ramirez-Lorca R | 2004 | Hum Mutat2004，23，： | 1 |
| 2 | Cloning,mapping and expression analysis of VPS33B,the human orthologue of rat Vps33 b显示文摘 | Carim L Sumoy L Andreu N | | 0，，： | 1 |
| 3 | Human vitamin K --dependent GAS6: gene structure,allelic variation,and associ- ation with stroke显示文摘 | Munoz X Sumoy L Ramirez--Lorca R | 2004 | Hum Mutat2004，23，： | 1 |
| 4 | Identificationand expression analysis of C3orfl,a novel human genehomologous to the Drosophila RP 140-upstream gene显示文摘 | Escarceller M Pluvinet R Sumoy L | 2000 | DNA Seq2000，，11： | 1 |
| 5 | Human vita- min K-dependent GAS6:Gene structure,allelic variation,and association with stroke显示文摘 | MUNOZ X SUMOY L R AMfREZ LORCA R | 2004 | Hum Mutat2004，23，5： | 1 |
| 6 | Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells显示文摘 | Abate-Daga D Garcia-Rodriguez L Sumoy L | 2010 | Biochim Biophys Acta2010，1803，10： | 1 |
| 7 | Human vitamin K- dependent GAS6: gene structure, allelie variation, and association with stroke显示文摘 | Munoz X Sumoy L Ramircz-Lorca R | 2004 | Hum Mutat2004，23，： | 1 |
| 8 | Human vitamin K-dependent GAS62 gene structure, allelic variation, and asso-eiation with stroke显示文摘 | Munoz X Sumoy L Ramirez-Lorca R | 2004 | Hum Mutat2004，23，： | 1 |
| 9 | Human vitamin K-dependent GAS6 gene structure, allelic variation, and association with stroke 显示文摘 | MUNOZ X SUMOY L RAMiREZ-LORCA R | 2004 | Hum Mutat2004，23，5： | 1 |
| 10 | Human vitamin K-dependent GAS6: gene structure, allelic variation, and asso- ciation with stroke 显示文摘 | Munoz X Sumoy L Ramirez-Lorca R | 2004 | Hum Mutat2004，23，： | 1 |
| 11 | Human vitamin K-dependent GAS6:gene structure, allelic variation,and association with stroke 显示文摘 | Munoz X Sumoy L Ramirez-Lorca R | 2004 | Hum Mutat2004，23，5： | 1 |
| 12 | Human vitamin K-dependent GAS6:gene structure,allelic variation,and association with stroke显示文摘 | MUNOZ X SUMOY L RAMIREZ-LORCA R | 2004 | Hum Mutat2004，23，： | 1 |
| 13 | Gene expression changes in blood RNA after swimming in a chlorinated pool显示文摘Exposure to disinfection by-products(DBP) such as trihalomethanes(THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes in blood gene expression of adult recreational swimmers after swimming in a chlorinated pool. Volunteers swam 40 min in an indoor chlorinated pool. Blood samples were drawn and four THM(chloroform,bromodichloromethane, dibromochloromethane and bromoform) were measured in exhaled breath before and after swimming. Intensity of physical activity was measured as metabolic equivalents(METs). Gene expression in whole blood m RNA was evaluated using Illumina Human HT-12v3 Expression-Bead Chip. Linear mixed models were used to evaluate the relationship between gene expression changes and THM exposure. Thirty-seven before-after pairs were analyzed. The median increase from baseline to after swimming were: 0.7 to 2.3 for MET, and 1.4 to 7.1 μg/m^3 for exhaled total THM(sum of the four THM).Exhaled THM increased on average 0.94 μg/m^3 per 1 MET. While 1643 probes were differentially expressed post-exposure. Of them, 189 were also associated with exhaled levels of individual/total THM or MET after False Discovery Rate. The observed associations with the exhaled THM were low to moderate(Log-fold change range:-0.17 to 0.15). In conclusion, we identified short-term gene expression changes associated with swimming in a pool that were minor in magnitude and their biological meaning was unspecific. The high collinearity between exhaled THM levels and intensity of physical activity precluded mutually adjusted models with both covariates. These exploratory results should be validated in future studies. | Lucas A.Salas Laia Font-Ribera Mariona Bustamante Lauro Sumoy Joan O.Grimalt Sarah Bonnin Maria Aguilar Heidi Mattlin Manuela Hummel Anna Ferrer Manolis Kogevinas Cristina M.Villanueva | 2017 | Journal of Environmental Sciences2017，29，8： | 0 |
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