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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | 应用高压水射流作为一种高效率的磨煤工具显示文摘 | Mazurkiewicz M Summers D A | 1986 | 高压水射流1986，，2： | 2 |
| 3 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 4 | Effects of deletion and overexpression of the Autographa califomica nuclear polyhedrosis vires FP25K gene on synthesis of two occlusionderived virus envelope proteins and their transport into virusinduced intranuclear membranes显示文摘 | Rosas-Acosta G Braunagel S C & Summers M D | 2001 | J Virol2001，75，10： | 1 |
| 5 | Trends in the development of baculovirus expression vectors显示文摘 | Luekow V A Summers M D | 1988 | Biotechnology1988，6，： | 1 |
| 6 | Diagenesis and preservation of porosity in Norphlet Formation (Upper Jurassic), southern Alabama显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Pet Geol Bull1989，73，： | 1 |
| 7 | Effect of dietary protein and energyon broiler carcasec composition and efficiency of nutrient utilization显示文摘 | Jackson S Summers J D Leeson S | 1982 | Poultry Science1982，61，： | 1 |
| 8 | Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Thl) and Thl7 nephritogenic immunity in experimental crescentic glomerulonephritis显示文摘 | Summers SA Phoon RK Odobasic D | 2011 | Clin Exp Immunol2011，166，2： | 1 |
| 9 | A Model for Stochastic Acceleration of Electrons During Geomagnetic Storms显示文摘 | Thorne R M Xiao F L | 2000 | Adv Space Res2000，25，12： | 1 |
| 10 | Quantification of Oxidized Metallothionein in Biological Material by a CA Saturation Method显示文摘 | Klein D Sato S Summer K H | 1994 | Anal Biochem1994，221，2： | 1 |
| 11 | Experimental investigation on the breakage of hard rock by the PDC cutters with combined action modes 显示文摘 | LI Xi -bing Summers D A Rupert G | 2001 | Tunnelling and Underground Space Technology2001，16，： | 1 |
| 12 | Response of laying hens to supplemental niacin显示文摘 | LEESON S CASTON L J SUMMERS J D | 1991 | Poultry Science1991，70，5： | 1 |
| 13 | Large-scale hexagonal-patterned growth of aligned ZnO nanorods for nano-optoelectronics and nanosensor arrays显示文摘 | WANG X D SUMMERS C J WANG Z L | 2004 | Nano Letters2004，4，3： | 1 |
| 14 | Diagenesis and prservation of porosity in Norphlet Formation( Upper Jurassic) , southern Alabama 显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Petrol Geol Bull1989，73，6： | 1 |
| 15 | Laying hen performance as influenced by protein intake to sixteen weeks of age and body weight at point of lay显示文摘 | Leeson S | 1994 | J Poultry Sci1994，73，： | 1 |
| 16 | Diagenesis and prservation of porosity in Norphlet Formation(Upper Jurassic),southern Alabama显示文摘 | Dixon S A Summers D M Surdam R C | 1989 | American Association of Petroleum Geologists Bulletin1989，73，6： | 1 |
| 17 | Structm and evolutionary implication of a'cysteine-rich'Campoletis sonorensis polydnavirus gene family Proc显示文摘 | Dib-Hajj S D Webb B A Summer M D | 1993 | Natl Acad Sci1993，90，： | 1 |
| 18 | Translocation and cleavage of rubella virus envelope glycoproteins: identification and role of the E2 signal sequence显示文摘 | Oker-Blom C Jarvis D L Summers M D | 1990 | J Gen Virol1990，71，： | 1 |
| 19 | Investigation into the penetration and impact resistance of PDC cutters inclined at different attack angles显示文摘 | LI Xi - bing Summers D A Rupert G | 2001 | Transation of Nonferrous Metals Society of China2001，10，2： | 1 |
| 20 | A novel chemokine receptor for SDF-1 and I-TAC involved in cell sunrival,eell adllesion,and tumor development显示文摘 | Burns JM Summers BC Wang Y et d | 2006 | J Exp Med2006，203，9： | 1 |
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