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| 1 | Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis显示文摘AIM:To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer(CC)or high grade dysplasia(HGD).METHODS:This is a single center(Lenox Hill Hospital)retrospective cohort and descriptive study of extensive ulcerative colitis(UC)for 20 years or more with a minimum of 3 surveillance colonoscopies and biopsies performed after the first 10 years of UC diagnosis.Data analyzed included:duration of UC,date of diagnosis of(CC)or(HGD),number of surveillance colonoscopies,and biopsies showing histological inflammation and its severity in each of 6 segments when endoscopic appearance is normal.Two subgroups of patients were compared:group 1 patients who developed CC/HGD and group 2 patients who did not develop CC/HGD.RESULTS:Of 115 patients with longstanding UC reviewed,68 patients met the inclusion criteria.Twenty patients were in group 1 and 48 in group 2.We identified the number of times for each patient when the endoscopic appearance was normal but biopsies nevertheless showed inflammation.Overall,histological disease activity in the absence of gross/endoscopic disease was found in 31.2%(95%CI:28%-35%)of colonoscopies performed on the entire cohort of 68 patients.Histological disease activity when the colonoscopy showed an absence of gross disease activity was more common in group 1 than group 2 patients,88%(95%CI:72%-97%)vs 59%(95%CI:53%-64%).Only 3/20(15%)of patients in group 1 ever had a colonoscopy completely without demonstrated disease activity(i.e.,no endoscopic or histological activity)as compared to 37/48(77%)of patients in group 2,and only 3.3%(95%CI:0.09%-8.3%)of colonoscopies in group 1 had no histological inflammation compared to23%(95%CI:20%-27%)in group 2.CONCLUSION:Progression to HGD or CC in extensive ulcerative colitis of long standing was more frequently encountered among those patients who demonstrate persistent histological inflammation in the absence of gross mucosal disease.Our findings support including the elimination of histological inflammation in the definition of mucosal healing,and support this endpoint as an appropriate goal of therapy because of its risk of increasing dysplasia and colon cancer. | Burton I Korelitz Keith Sultan Megha Kothari Leo Arapos Judy Schneider Georgia Panagopoulos | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 2 | Applications of MOSFET dosimeters on MIR and BION satellites显示文摘 | Thomson I Sultan N | 1997 | IEEE TransNuclSci1997，44，6： | 1 |
| 3 | Determinants and consequences of trust in e-business:a large scale empirical study显示文摘 | SULTAN F URBAN G L SHANKAR V BART I | 2002 | Sloan school of Management MIT Working Paper2002，2002，： | 1 |
| 4 | Effect of aprotinin to improve myocardial viability in myocardial preservation followed by reperfusion 显示文摘 | Sunamori M Sultan I Suzuki A | 1991 | Ann Thorac Surg1991，52，4： | 1 |
| 5 | Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and end results database显示文摘 | Qaddoumi I Sultan I Gajjar A | 2009 | Cancer2009，115，24： | 1 |
| 6 | Optimization of improved suspension system with inerter device of the quarter-car model in vibration analysis显示文摘 | Kuznetsov A Mammadov M Sultan I | 2010 | Archive of Applied Mechanics2010，81，10： | 1 |
| 7 | The effect of inlet parameters on the performance of packed tower-regenerator 显示文摘 | SULTAN G I MAHMED A | 2002 | Renewable Energy2002，26，： | 1 |
| 8 | Stillbirth during infection with Middle East respiratory syndrome coronavirus显示文摘 | Daniel CP Ibrahim I Sultan A | 2014 | J Infect Dis2014，，209： | 1 |
| 9 | In- flammatory myofibroblastic tumor causing unex- plained anemia in a toddler: a case report显示文摘 | SALAMEH M SULTAN I BARBAR M | 2011 | J Med Case Reports2011，5，： | 1 |
| 10 | Current state of research on cross-site scripting(XSS)-A systematic literature review显示文摘 | Hydara I Sultan A B M Zulzalil H | 2015 | Information & Software Technology2015，，： | 1 |
| 11 | Optimiza- tion of improved suspension system with inerter device of the quarter-car model in vibration analysis 显示文摘 | Kuznetsov A Mammadov M Sultan I | 2011 | Archive of Applied Mechanics2011，18，10： | 1 |
| 12 | Pineal gland tu-mors: experience from the SEER database 显示文摘 | Al-Hussaini M Sultan I Abuirmileh N | 2009 | J Neurooncol2009，94，3： | 1 |
| 13 | Age, stage, and radiotherapy, but not primary tumor site, affects the outcome of patients with malignant rhabdoid tumors显示文摘 | Sultan I Qaddoumi I Rodriguez-Galindo C | 2010 | Pediatr Blood Cancer2010，54，： | 1 |
| 14 | Regulation of the sphingosine recycling pathway for ceramide generation by oxidative stress,and its role in controlling c-Myc/Max function 显示文摘 | Sultan I Senkal CE Ponnusamy S | 2006 | Biochem J2006，393，2： | 1 |
| 15 | Transoral laser surgery for early glottic cancers显示文摘 | Sultan A P Prathamesh S P Siddalingeshwar I N | 2003 | Archives Otolaryngol Head Neck Surg2003，129，6： | 1 |
| 16 | Soft tissue sarcoma across the age spectrum: a population-based study from the surveillance epidemiology and end results database显示文摘 | Ferrari A Sultan I Huang TI' | 2011 | Pediatr Blood Cancer2011，57，： | 1 |
| 17 | Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades显示文摘 | Moss K E Ioannou Y Sultan S M Haq I Isenberg D A | 2002 | Ann Rheum Dis2002，61，： | 1 |
| 18 | The significant role of membrane stabilization in hypothermic cardioplegic cardiac preservation in a canine experimental model显示文摘 | Sunamori M Sultan I Shirai T | 1992 | Transpl Int1992，5，1： | 1 |
| 19 | Outcome and prognostic features in pediatric gliomas:a review of 6212 cases from the Surveillance, Epidemiology, and End Results database 显示文摘 | Qaddoumi I Sultan I Gajjar A | 2009 | Cancer2009，115，24： | 1 |
| 20 | Joint spectrum sensing for detection of primary users using cognitive re- lays withevolutionary computing 显示文摘 | Salman A Qureshi I M Sultan K | 2015 | Communications IET2015，9，13： | 1 |
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