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| 1 | 血清乙型肝炎病毒DNA水平的生物学梯度与肝细胞肝癌的风险性相关显示文摘Context: Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B. Objective: To evaluate the relationship between serum HBV DNA level and risk of hepatocellular carcinoma. Design, Setting, and Participants: Prospective cohort study of 3653 participants (aged 30-65 years), who were seropositive for the hepatitis B surface antigen and seronegative for antibodies against the hepatitis C virus, recruited to a community-based cancer screening program in Taiwan between 1991 and 1992. Main Outcome Measure: Incidence of hepatocellular carcinoma during follow-up examination and by data linkage with the national cancer registry and the death certification systems. Results: There were 164 incident cases of hepatocellular carcinoma and 346 deaths during a mean follow-up of 11.4 years and 41 779 person-years of follow-up. The incidence of hepatocellular carcinoma increased with serum HBV DNA level at study entry in a dose-response relationship ranging from 108 per 100 000 person-years for an HBV DNA level of less than 300 copies/mL to 1152 per 100 000 person-years for an HBV DNA level of 1 million copies/mL or greater. The corresponding cumulative incidence rates of hepatocellular carcinoma were 1.3%and 14.9%, respectively. The biological gradient of hepatocellular carcinoma by serum HBV DNA levels remained significant (P< .001) after adjustment for sex, age, cigarette smoking, alcohol consumption, serostatus for the hepatitis B e antigen (HBeAg), serum alanine aminotransferase level, and liver cirrhosis at study entry. The dose-response relationship was most prominent for participants who were seronegative for HBeAg with normal serum alanine aminotransferase levels and no liver cirrhosis at study entry. Participants with persistent elevation of serum HBV DNA level during follow-up had the highest hepatocellular carcinoma risk. Conclusion: Elevated serum HBV DNA level (>10 000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis. | Chen C.-J. Yang H. -I. Su J. 王铮(译) 陈云茹(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 204 |
| 2 | 根据循环乙型肝炎病毒载量预测肝硬化的危险性显示文摘肝硬化是慢性乙型肝炎肝脏炎症和由肝脏炎症引起的肝纤维化的结果。1991~1992年,对3582例未曾接受治疗下预的中国台湾籍乙型肝炎病毒感染者被纳入一项基于人群的前瞻性队列研究。研究起点为血清HBVDNA阳性和超声诊断肝硬化阴性。结果在平均11年的随访期内,3582例病人共随访40038人年,其中365例病人被诊断为肝硬化。 | Iloeje UH Yang HI Su J 陆伟(摘译) 张占卿(审校) | 2006 | 世界感染杂志2006，6，4： | 202 |
| 3 | Risk assessment of heavy metals in soils and vegetables around nonferrous metals mining and smelting sites,Baiyin,China显示文摘A field survey was conducted to investigate the metal and arsenic contamination in soils and vegetables on four villages (Shuichuan (SCH), Beiwan (BWA), Dongwan (DWA) and Wufe (WFE)) located along, Baiyin, China, and to evaluate the possible health risks to local population through foodchain. Results show that the most significantly contaminated soils occurred upstream at SCH where Cd, Cu and As concentrations exceeded maximum allowable concentrations for Chinese agricultural soil. Further downstream the degree of contamination semi-systematically decreased in concentrations of metal. Generally, the leafy vegetables were more heavily contaminated than non-leafy vegetables. Chinese cabbage is the most severely contaminated, the concentrations of Cd exceeded the maximum permit levels (0.05 mg/kg) by 4.5 times. Bio-accumulate factor also shows that an entry of Cd to food chain plants is the greatest potential. Furthermore, the estimated daily intake amounts of the considered toxic elements (Cd, Pb and Cu) from the vegetables grown at SCH and BWA and DWA have exceeded the recommended dietary allowance levels. Thus, the vegetables grown in three villages above, which affected by Baiyin mining and smelting have a health hazard for human consumption. | LI Yu WANG Yan-bin GOU Xin SU Yi-bing WANG Gang | 2006 | Journal of Environmental Sciences2006，18，6： | 84 |
| 4 | Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight显示文摘谷物重量是庄稼谷物产量的一个主要决定因素并且被自然地发生的量的特点 loci (QTL ) 控制。我们更早识别了控制米饭谷物宽度和重量的主要 QTL, GW5,它在米饭染色体 5 上被印射到一个再结合热点。获得 GW5 怎么控制米饭谷物宽度的更好的理解,我们进行了这个地点的好印射并且揭开在米饭栽培变种 Asominori 与增加的谷物宽度联系的 1 212-bp 删除,与苗条谷物米饭 IR24 比较。另外, 46 米饭栽培变种的 genotyping 分析表明这删除高度与谷物宽度显型被相关,建议 GW5 删除可能在米饭驯服期间被选择了。GW5 编码对原子核局部性的 144 氨基酸的新奇原子蛋白质。而且,我们证明 GW5 身体上在酵母与 polyubiquitin 交往二混血儿的试金。一起,我们的结果建议 GW5 代表主要 QTL 内在的米饭宽度和重量,并且它多半在 ubiquitin-proteasome 小径行动在种子开发期间调整房间分割。这研究提供新奇卓见进控制米饭谷物开发的分子的机制并且建议 GW5 能为庄稼的产量很高的繁殖用作一个潜在的工具。 | Jianfeng Weng Suhai Gu Xiangyuan Wan He Gao Tao Guo Ning Su Cailin Lei Xin Zhang Zhijun Cheng Xiuping Guo Jiulin Wang Ling Jiang Huqu Zhai Jianmin Wan | 2008 | Cell Research2008，18，12： | 248 |
| 5 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 6 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 7 | Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma:A literature review显示文摘Hepatoid adenocarcinoma (HAC) is a rare but important special type of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma (HCC), and prompt and correct diagnosis can be a challenge, especially in endemic areas with a high incidence of HCC. To date, HAC has only been reported in case series or single case reports, so we aimed to review the clinicopathological characteristics of HAC to obtain a more complete picture of this rare form of extrahepatic adenocarcinoma. All the articles about HAC published from 2001 to 2011 were reviewed, and clinicopathological findings were extracted for analysis. A late middle-aged male with high serum α-fetoprotein and atypical image finding of HCC should raise the suspicion of HAC, and characteristic pathological immunohistochemical stains can help with the differential diagnosis. Novel immunohistochemical markers may be useful to clearly differentiate HAC from HCC. Once metastatic HAC is diagnosed, the primary tumor origin should be identified for adequate treatment. The majority of HAC originates from the stomach, so panendoscopy should be arranged first. | Jiann-Sheng Su Yu-Tso Chen Ren-Ching Wang Chun-Ying Wu Shou-Wu Lee Teng-Yu Lee | 2013 | World Journal of Gastroenterology2013，19，3： | 75 |
| 8 | Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair显示文摘间充质的干细胞(MSC ) 为治疗各种各样的疾病有大潜力,特别那些与织物有关损坏包含有免疫力的反应。各种各样的研究证明了 MSC 在 vitro 并且在 vivo 是强烈抑制免疫力的。我们的最近的研究证明了那未刺激的 MSC 确实不能免疫力的抑制;他们与 TNF- 伪, IL-1 伪或 IL-1 尾与激活的淋巴细胞的上层清液,或与 IFN- 纬的联合在刺激之上变得 potently 抑制免疫力。这观察表明在某些情形下面,煽动性的 cytokines 能实际上变得抑制免疫力。我们证明在调停 MSC 的免疫力的抑制的机制有一个种类变化:由告知 cytokine 的老鼠 MSC 的免疫力的抑制被氮的氧化物调停(没有) 而由告知 cytokine 的人的 MSC 的免疫力的抑制通过 indoleamine 被执行 2, 3-dioxygenase (伊多语) 。在有煽动性的 cytokines 的刺激之上,另外,老鼠和人的 MSC 分泌几白血球 chemokines 显然服务与 MSC 吸引有免疫力的房间进最近,在哪儿不或伊多语被预言很活跃。因此,由煽动性的刺激 cytokine 的 MSC 的免疫力的抑制经由 chemokines 的一致行动发生并且免疫者禁止没有或伊多语由 MSC 生产了。因此,我们的结果在对待有免疫力的回答导致的织物损害关于调停 MSC 的免疫力的抑制并且为 MSC 的更好的申请的机制提供新奇信息。 | Yufang Shi Gangzheng Hu Juanjuan Su Wenzhao Li Qing Chen Peishun Shou Chunliang Xu Xiaodong Chen Yin Huang Zhexin Zhu Xin Huang Xiaoyan Han Ningxia Xie Guangwen Ren | 2010 | Cell Research2010，20，5： | 72 |
| 9 | Effects of autumn-winter Arctic sea ice on winter Siberian High显示文摘The intensity of the winter Siberian High has significantly negative correlations with Arctic sea ice concentration anomalies from the previous autumn to winter seasons in the Eastern Arctic Ocean and Siberian marginal seas. Our results indicate that autumn-winter Arctic sea ice concentration and concurrent sea surface temperature anomalies are responsible for the winter Siberian High and surface air temperature anomalies over the mid-high latitudes of Eurasia and East Asia. Numerical experiments also support this conclusion, and consistently show that the low sea ice concentration causes negative surface air temperature anomalies over the mid-high latitudes of Eurasia. A mechanism is proposed to explain the association between autumn-winter sea ice concentration and winter Siberian High. Our results also show that September sea ice concentration provides a potential precursor for winter Siberian High that cannot be predicted using only tropical sea surface temperatures. In the last two decades (1990–2009), a strengthening trend of winter Siberian High along with a decline trend in surface air temperature in the mid-high latitudes of the Asian Continent have favored the recent frequent cold winters over East Asia. The reason for these short-term trends in winter Siberian High and surface air temperature are discussed. | WU BingYi SU JingZhi ZHANG RenHe | 2011 | Chinese Science Bulletin2011，56，30： | 70 |
| 10 | Composition Modeling and Equivalence of an Integrated Power Generation System of Wind, Photovoltaic and Energy Storage Unit显示文摘利用间接组合建模的方法,在建立典型的双馈风机、光伏发电单元和储能单元的装置级机电暂态模型基础上,采用等值方法建立三者电站级的机电暂态模型,最终通过组合建模得到了风光储联合发电系统的机电暂态模型。在大型电力系统分析软件包的PSD-BPA暂态稳定程序中实现了风光储联合发电系统的仿真功能,通过典型算例和张北"国家风光储输示范工程"的仿真分析验证了模型的正确性,为风光储联合发电系统的并网研究提供了分析手段。 | WANG Haohuai TANG Yong HOU Junxian ZOU Jiangfeng LIANGShuang SU Feng | 2011 | 中国电机工程学报2011，31，34： | 66 |
| 11 | Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology显示文摘Salvia miltiorrhiza Bunge(SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy. | SU Chun-Yan MING Qian-Liang RAHMAN Khalid HAN Ting QIN Lu-Ping | 2015 | Chinese Journal of Natural Medicines2015，13，3： | 74 |
| 12 | High Prevalence of Gestational Diabetes Mellitus in Beijing: Effect of Maternal Birth Weight and Other Risk Factors显示文摘 | Wei-Wei Zhu Hui-Xia Yang Chen Wang Ri-Na Su Hui Feng Anil Kapur | 2017 | Chinese Medical Journal2017，，9： | 61 |
| 13 | 代谢产物右旋羟戊二酸抑制FTO/m6A/Myc/CEBPA通路的抗肿瘤作用显示文摘贝克曼研究所陈建军教授、芝加哥大学生化研究所何川教授、浙江大学附属第一医院血液科金洁教授及其研究团队合作发现:异柠檬酸脱氢酶(ISOdehydrogenase,IDH)突变造成的代谢产物右旋羟戊二酸(R-2-hydroxyglutarate,R-2HG)通过抑制FTO/m6A/Myc/CEBPA信号发挥抗白血病的作用。2011年,何川教授实验室证实肥胖相关蛋白(obesity-associated protein,FTO)是m6A去甲基转移酶。m6A是一种广泛存在的RNA修饰,参与RNA的剪接、转位、衰减、翻译等过程,参与维持机体稳态,并与疾病的发生发展密切相关,如肿瘤、炎症相关疾病等。FTO调节肿瘤的具体机制需要进一步被揭示。 | 朱哈 刘娟 Su R Dong L Li C | 2018 | 中国肿瘤生物治疗杂志2018，25，2： | 62 |
| 14 | The Beishan underground research laboratory for geological disposal of high-level radioactive waste in China:Planning, site selection,site characterization and in situ tests显示文摘With the rapid development of nuclear power in China, the disposal of high-level radioactive waste(HLW) has become an important issue for nuclear safety and environmental protection. Deep geological disposal is internationally accepted as a feasible and safe way to dispose of HLW, and underground research laboratories(URLs) play an important and multi-faceted role in the development of HLW repositories. This paper introduces the overall planning and the latest progress for China's URL. On the basis of the proposed strategy to build an area-specific URL in combination with a comprehensive evaluation of the site selection results obtained during the last 33 years, the Xinchang site in the Beishan area,located in Gansu Province of northwestern China, has been selected as the final site for China's first URL built in granite. In the process of characterizing the Xinchang URL site, a series of investigations,including borehole drilling,geological mapping, geophysical surveying,hydraulic testing and in situ stress measurements, has been conducted. The investigation results indicate that the geological,hydrogeological, engineering geological and geochemical conditions of the Xinchang site are very suitable for URL construction. Meanwhile, to validate and develop construction technologies for the Beishan URL, the Beishan exploration tunnel(BET), which is a 50-m-deep facility in the Jiujing sub-area, has been constructed and several in situ tests, such as drill-and-blast tests, characterization of the excavation damaged zone(EDZ), and long-term deformation monitoring of surrounding rocks, have been performed in the BET. The methodologies and technologies established in the BET will serve for URL construction.According to the achievements of the characterization of the URL site, a preliminary design of the URL with a maximum depth of 560 m is proposed and necessary in situ tests in the URL are planned. | Ju Wang Liang Chen Rui Su Xingguang Zhao | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 62 |
| 15 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 16 | Trends and Challenges for Population and Health During Population Aging——China,2015-2050显示文摘Summary What is already known about this topic?As the largest country in the world,China experienced a demographic transition at a historic scale during the past 50 years with extraordinarily associated changes in the age structure of the population,declining fertility rates,accelerating process of population aging,and growing population scale. | Yanan Luo Binbin Su Xiaoying Zheng | 2021 | China CDC weekly2021，3，28： | 61 |
| 17 | Morinda citrifolia (Noni): A literature review and recent advances in Noni research^1显示文摘Morinda citrifolia L(Noni) has been used in folk remedies by Polynesians for over 2000 years,and is reported to have a broad range of therapeutic effects,including antibacterial,antiviral,antifungal,antitumor,antihelmin,analgesic,hypotensive,anti-inflammatory,and immune enhancing effects.In order to reveal the nutritional and medicinal value of the Noni plant,and to summarize scientific evidence that supports the Polynesians' claim,a literature review and recent advances in Noni research is given below. | Brett J WEST CJarakae JENSEN Diane NOWICKI SU Chen Afa K PALU Gary ANDERSON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 80 |
| 18 | Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection显示文摘AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori ) infection. METHODS:This open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid , clarithromycin 500 mg bid , and amoxicillin 1000 mg bid ; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 107 Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods. RESULTS:PP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction. CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. | Yi-Qi Du Tun Su Jian-Gao Fan Yu-Xia Lu Ping Zheng Xing-Hua Li Chuan-Yong Guo Ping Xu Yan-Fang Gong Zhao-Shen Li | 2012 | World Journal of Gastroenterology2012，18，43： | 54 |
| 19 | RNA N^6-methyladenosine modification in cancers: current status and perspectives显示文摘 | Xiaolan Deng Rui Su Hengyou Weng Huilin Huang Zejuan Li Jianjun Chen | 2018 | Cell Research2018，28，5： | 55 |
| 20 | Diagnostic value of PIVKA-Ⅱ and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma显示文摘AIM: To determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein(AFP) and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ) in chronic hepatitis B(CHB).METHODS: A total of 1255 patients with CHB, including 157 patients with hepatocellular carcinoma(HCC), 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The areas under the receiver operating characteristic(AUROC) curves of PIVKA-Ⅱ, AFP and their combination were calculated and compared.RESULTS: The optimal cutoff values for PIVKA-Ⅱ and AFP were 40 m AU/m L and 10 ng/m L, respectively, for the differentiation of HCC from nonmalignant CHB. The sensitivity and specificity were 73.9% and 89.7%, respectively, for PIVKA-Ⅱ and 67.5% and 90.3% for AFP, respectively. The AUROC curves of both PIVKA-Ⅱ and AFP were not significantly different(0.854 vs 0.853, P = 0.965) for the differentiation of HCC from nonmalignant CHB, whereas the AUROC of PIVKA-Ⅱ was significantly better than that of AFP in patients with cirrhosis(0.870 vs 0.812, P = 0.042). When PIVKA-Ⅱ and AFP were combined, the diagnostic power improved significantly compared to either AFP or PIVKA-Ⅱ alone for the differentiation of HCC from nonmalignant CHB(P < 0.05), especially when cirrhosis was present(P < 0.05).CONCLUSION: Serum PIVKA-Ⅱ might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB. | Seung In Seo Hyoung Su Kim Won Jin Kim Woon Geon Shin Doo Jin Kim Kyung Ho Kim Myoung Kuk Jang Jin Heon Lee Joo Seop Kim Hak Yang Kim Dong Joon Kim Myung Seok Lee Choong Kee Park | 2015 | World Journal of Gastroenterology2015，21，13： | 60 |
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