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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Immunomodulation by dietary β-1,3-glucan in the brooders of the black tiger shrimp Penaeus monodon显示文摘 | Chang C F Chen H Y Su M S | 2000 | Fish Shellfish Immun2000，10，： | 2 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | A survey on sensor networks 显示文摘 | Akyildiz L F Su Wenlian Sankarasubramania M Y | 2011 | IEEE Communications Magazine2011，40，8： | 1 |
| 5 | Effect of rainwater harvesting with ridge and furrow on yield of potato in semiarid areas显示文摘 | Tian Y Su D R Li F M | 2003 | Field Crops Research2003，84，3： | 1 |
| 6 | Porous texture of activated carbons prepared by phos-phoric acid activation of apple pulp显示文摘 | Suárez-García F Martínez-Alonso A Tascón J M D | | 0，，： | 1 |
| 7 | An Iterative Method of Solution for Equilibrium and Optimization Problems显示文摘 | SU Y F SHANG M J QIN X L | 2008 | Nonlinear Anal2008，64，： | 1 |
| 8 | The value of 18F-FDG-PET/CT in the differential diagnosis of solitary pulmonary nodules in areas with a high incidence of tuberculosis显示文摘 | Li Y Su M Li F | 2011 | Ann Nuel Med2011，25，10： | 1 |
| 9 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Development and characterization of an aerosol time-of-flight mass spectrometer with increased detection efficiency显示文摘 | SU Y X SIPIN M F FURUTANI H | 2004 | Analytical Chemistry2004，76，3： | 1 |
| 11 | In Vitro Cell Studies of Technetium-99m Labeled RGD-HYNIC Peptide, a Comparison of Tricine and EDDA as CoLigands显示文摘 | Su Z F He J Rusckowski M | 2003 | Nucl Med Biol2003，30，： | 1 |
| 12 | Effect of Calcium Sulfate Concentration in Soymilk on the Microstructure of Firm Toil/and the Protein Consti- tutions in Tofu Whey显示文摘 | KAO F SU N LEE M | 2003 | Journal of Agricultural and Food Chemistry2003，51，： | 1 |
| 13 | Control of the chemical structure of perhydrous coals : FTIR and Py-GC/MS investigation显示文摘 | IGLESIAS M J del RIIO J C LAGGOUN-D FARGE F CUESTA M J SU REZ-RUIZ I | 2002 | J Anal Appl Pyrolysis2002，62，1： | 1 |
| 14 | Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor,PTEN显示文摘 | Xie F Su M Qiu W | 2013 | Int J Mol Sci2013，14，21： | 1 |
| 15 | Microvesicles secreted by macrophages shuttle invasion- potentiating mieroRNAs into breast cancer cells显示文摘 | Yang M Chen J Su F | 2011 | Mol Cancer2011，10，： | 1 |
| 16 | A novel method for synthesis of layered LiNilCol,-MnlaO2 as cathode material for lithium-ion ba- ttery显示文摘 | WU F WANG M SU Y F | 2010 | Journal of Power Sources2010，195，： | 1 |
| 17 | Emotional and behavioral problems of Chinese left-behind children:A preliminary study显示文摘 | Fan F Su L Gill M K | 2010 | Soc Psychiatry Psychiatr Epidemiol2010，45，6： | 1 |
| 18 | Cooperative Ox ygen Ion Dynamics in Cd2Ti2-yZryO7显示文摘 | Moreno K J Suárez C M Fuentes A F | 2005 | Physical Review B2005，71，13： | 1 |
| 19 | Effect of rainwater harvesting with ridge and furrow on yield of potato in semiarid areas显示文摘 | Tian Y Su D R Li F M | 2003 | Field crop research2003，84，： | 1 |
| 20 | Purification of single walled carbon nanotubes synthesized by the catalytic decomposition of hydrocarbons显示文摘 | F LI H M CHENG Y T XING P H TAN G SU | 2000 | Carbon2000，38，： | 1 |
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