|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases显示文摘 | Warren Strober Ivan J. Fuss | 2011 | Gastroenterology2011，，6： | 8 |
| 3 | Assessment of Depression in Three Medically ill, Elderly Populations: Alzheimer’s Disease, Parkinson’s Disease, and Stroke显示文摘 | Lauren B. Strober Peter A. Arnett | 2009 | The Clinical Neuropsychologist2009，，2： | 2 |
| 4 | THE IMMUNOLOGY OF MUCOSAL MODELS OF INFLAMMATION 1显示文摘 | Warren Strober Ivan J. Fuss Richard S. Blumberg | 2002 | Annual Review of Immunology2002，，： | 2 |
| 5 | Therapeutics in duchenne muscular dystrophy 显示文摘 | Strober JB | 2006 | NeuroRx2006，3，2： | 1 |
| 6 | Efficacy and safety of tofacitinib,an oral Janus kinase inhibitor,in the treatment of psoriasis:a Phase 2b randomized placebo-controlled dose-ranging study显示文摘 | Papp K Menter A Strober B | 2012 | Br J Dermatol2012，167，3： | 1 |
| 7 | The fundamental basis of inflammatory bowel disease显示文摘 | Strober W Fuss I Mannon P | 2007 | J Clin Invest2007，117，3： | 1 |
| 8 | The T cell-B cell interaction via OX40- OX40L is necessary for the T cell-dependent humoral immune re- sponse显示文摘 | Stuber E Strober W | 1996 | J Exp Med1996，183，3： | 1 |
| 9 | Cell contact-dependent immunosuppression by CD4^+ CD25^+ T regulatory cells is mediated cell surface-bound transforming growthing factor-β显示文摘 | Nakamura K Kitani A Strober W | 2001 | J Exp Med2001，194，5： | 1 |
| 10 | SAPHO syndrome associated with hidradenitis suppurativa successfully treated with infliximab and methotrexate 显示文摘 | De Souza A Solomon GE Strober BE | 2011 | Bull NYU Hosp Jt Dis2011，69，2： | 1 |
| 11 | IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-betal production and fibrosis显示文摘 | Fichtner-Feigl S Strober W Kawakami K | 2006 | Nat Med2006，12，1： | 1 |
| 12 | TNBS-colitis 显示文摘 | NEURATH M FUSS I STROBER W | 2000 | Int Rev Immunol2000，19，1： | 1 |
| 13 | Actinic granuloma 显示文摘 | Stein JA Fangman B Strober B | 2007 | Dermatol Online J2007，13，1： | 1 |
| 14 | High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis显示文摘 | Marth T Strober W Kelsall BL | 1996 | J Immunol1996，157，： | 1 |
| 15 | Animal models of mucosal inflammation and their relation to human inflammatory bowel disease显示文摘 | Blumberg RS Saubermann LJ Strober W | 1999 | Curr Opin Immunol1999，11，6： | 1 |
| 16 | Animal models of inflammatory bowel diseasean overview显示文摘 | | 1985 | Dig Dis Sci1985，，： | 1 |
| 17 | STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation显示文摘 | Morinobu A Gadina M Strober W | 2002 | Proe Natl Acad Sci USA2002，99，12： | 1 |
| 18 | Cell contact-dependent immunosuppression by CD4+CD25+regulatory T cells is mediated by cell surface-bound transforming growth factor beta 显示文摘 | Nakamura K Kitani A Strober W | 2001 | J Exp Med2001，194，5： | 1 |
| 19 | An open-label, single-arm pilot study in patients withsevere plaque-type psoriasis treated with an oral antiinflammatory agent, apremilast 显示文摘 | Gottlieb A B Strober B Krueger J G | 2008 | Curr Med Res Opin2008，24，5： | 1 |
| 20 | An open-label,singlearm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent,apremilast显示文摘 | Gottlieb AB Strober B Kmeger JG | 2008 | Curr Med Res Opin2008，24，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员