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1篇 您的检索式：作者名="Steven Freear"

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		题名	作者	年代	出处	被引量
	1	Combined flow-focus and self-assembly routes for the formation of lipid stabilized oil-shelled microbubbles显示文摘Lipid and polymer stabilized microbubbles are used in medicine as contrast agents for ultrasound imaging and are being developed for the delivery of water soluble drugs to diseased areas of the body.However,many new therapeutics exhibit poor water solubility or stability,which has led to the requirement for the development of effective hydrophobic drug delivery systems.This study presents a new method to produce microbubbles coated with an oil layer capable of encapsulating hydrophobic drugs and suitable for targeted,triggered drug release.This new method utilizes highly controllable flow-focusing microfluidics with lipid oil nanodroplets self-assembling and spreading at gas–aqueous interfaces.Oil layer inside microbubbles were produced with diameters of 2.4±0.3μm(s.d.,1.6μm)and at concentrations up to 10^(6) bubbles per milliliter.The mechanism of oil layer inside microbubble assembly and stability were characterized using methods including contact angle measurements,quartz crystal microbalance with dissipation monitoring and fluorescence resonance energy transfer imaging.	Adam H.Churchman Victoria Mico Julia Gala de Pablo Sally A.Peyman Steven Freear Stephen D.Evans	2018	Microsystems & Nanoengineering2018，4，1：	0

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