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| 1 | All for CD91 and CD91 for all显示文摘 | Justin Stebbing Philip Savage Steve Patterson | 2004 | Journal of Antimicrobial Chemotherapy2004，53，： | 1 |
| 2 | Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients显示文摘There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV)co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial.We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4count, HIV- 1 RNA viral load and therapy, to HIV- 1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Thl cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situation with HCV infection alone, this impairment was not reversed by increasing concentrations of either interleukin-2 or -12. Monocyte-derived DC from HIV-1 and HCV co-infected individuals have a similar allostimulatory capacity to DC from matched patients with HIV-1alone. These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals. | Justin STEBBING Steve PATTERSON Simon PORTSMOUTH Claire THOMAS Robert GLASSMAN Adrian WILDFIRE Frances GOTCH Mark BOWER Mark NELSON Brian GAZZARD | 2004 | Cell Research2004，14，3： | 1 |
| 3 | 用2.5D TSV实现多处理器SiP功能显示文摘本项目由Open-Silicon,GLOBALFOUNDRI ES和Amkor三家公司合作完成。两颗28nm的ARM处理器芯片,通过2.5D硅转接板实现集成。芯片的高性能集成通常由晶体管制程提高来实现,应用2.5D技术的Si P正成为传统芯片系统集成的有效替代。Open-Silicon负责芯片和硅转接板的设计,重点在于性能优化和成本降低。GLOBALFOUNDRI ES采用28nm超低能耗芯片工艺制造处理器芯片,而用65nm技术制造2.5D硅转接板。包括功耗优化和功能界面有效管理等概念得到验证。硅基板的高密度布线提供大量平行I/O,以实现高性能存储,并保持较低功耗。所开发的EDA设计参考流程可以用于优化2.5D设计。本文展示了如何将大颗芯片重新设计成较小的几颗芯片,通过2.5D硅转接板实现Si P系统集成,以降低成本,提高良率,增加设计灵活性和重复使用性,并减少开发风险。 | Deborah Patterson Mike Kelly Rick Reed Steve Eplett Zafer Kutlu Ramakanth Alapati | 2014 | 中国集成电路2014，23，11： | 1 |
| 4 | Moderate-intensity resistance exercise training in patients with chronic heart failure improves strength, endurance, heart rate variability, and forearm blood flow显示文摘 | Steve E. Selig Michael F. Carey David G. Menzies Jeremy Patterson Ralph H. Geerling Andrew D. Williams Voramont Bamroongsuk Deidre Toia Henry Krum David L. Hare | 2004 | Journal of Cardiac Failure2004，，1： | 1 |
| 5 | Validation of an epilepsy management smartphone application in Pakistan显示文摘Background:There is no single way to improve epilepsy care in low-and middle-income countries(LMICs).An epilepsy management aid application(app)has been described,which enables a non-physician health worker(NPHW)to communicate with an epilepsy specialist using a smartphone.In this study,we aimed to assess the validity and quality of this care system in building connections between NPHWs and specialists in Pakistan and the UK.Methods:A NPHW in Pakistan used the app on a series of referrals and sent the app-generated summary by email to a neurologist in the UK,who replied and suggested possible management.Patients were later seen in a face-to-face(FF)manner by the UK neurologist and a local neurologist,and diagnostic accuracy and quality parameters were assessed.Results:Over 10 months,59 patients were recruited and 33 of them were available for FF assessment.The misdiagnosis rate of the app was 6%(2 cases).Treatment advice provided by the app was judged appropriate in 32 patients(97%).In addition,46%of the referrals were completed within 2h and 85%within 24h.Conclusions:Consistent with an earlier study,this system is a safe method to provide care for patients who cannot access neurological services in person.In addition,it has advantage of timeliness compared to FF assessment and requires less specialist time,both of which are especially important during the coronavirus disease 2019 pandemic.This system can be generalised easily,depending on the willingness of referrers and specialists to use it. | Victor Patterson Awais Bashir Larik Mohamed Zaman Soomro Steve Coates | 2022 | Acta Epileptologica2022，5，1： | 0 |
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