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| 1 | 绞股蓝药材黄酮类化合物的HPLC指纹图谱研究显示文摘目的:建立绞股蓝药材黄酮类化合物的HPLC指纹图谱,对不同产地批次的绞股蓝药材进行质量评价。方法:用甲醇回流提取绞股蓝药材中的黄酮类成分,优化色谱条件,建立HPLC指纹图谱方法。选择了指纹图谱中的7个特征峰进行方法学考察,并用该方法测定了10个批次的绞股蓝药材。结果:精密度、稳定性、重复性考察结果表明,7个特征峰的相对保留时间的RSD值均小于0.5%,相对峰面积RSD值小于5%。分析了10批不同产地的绞股蓝药材,相似度结果均在0.8以上。结论:所建立的绞股蓝黄酮类化合物HPLC指纹图谱方法可以用于绞股蓝药材的质量评价。 | 刘芳 胡坪 Annika Küster 任德权 | 2009 | 中成药2009，31，4： | 13 |
| 2 | 中层顶波非线性相互作用的甚高频雷达观测研究显示文摘利用 SOUSY VHF雷达 1 987年 6月 2 2日至 6月 2 9日在挪威 Andoya的观测数据研究了中层顶附近大气风场中行星波、潮汐和惯性重力波的非线性相互作用。首先利用 Lomb- Scargle周期图方法计算了大气纬向风场的功率谱 ,除了行星波和潮汐外 ,在行星波、潮汐的频率和与频率差处有明显的谱峰 ,双谱分析表明这些谱峰是行星波和潮汐相互作用形成的。在 86.4km处 35h行星波、半日潮与 8.9h惯性重力波有较强的非线性耦合 ,半日潮与行星波间有明显的能量传输。半日潮振幅变化的周期为 78h,远大于行星波的周期。 85.2 km处经向风场半日潮振幅的变化周期同样大于与之相互作用的 33h行星波的周期。 | 熊建刚 易帆 J.Klostermeyer R.Rüster | 2000 | 电波科学学报2000，15，1： | 10 |
| 3 | Comparative study of polyhydroxyalkanoates production from acidified and anaerobically treated brewery wastewater using enriched mixed microbial culture显示文摘The production of polyhydroxyalkanoates(PHA) from wastewaters using microbial mixed cultures(MMC) has been attracting increased interest because of PHA's biodegradability characteristics. Production of PHA by an MMC enriched with PHA-accumulating bacteria was compared using anaerobically treated and acidified brewery wastewaters under various feeding strategies, namely pulse and batch feed addition. To obtain an enriched MMC, a sequencing batch reactor was inoculated with activated sludge fed with acetate and subjected to aerobic dynamic feeding. The enriched MMC was able to accumulate PHA up to 72.6% of cell dry weight(CDW) with pulse addition of acetate controlled by the dissolved oxygen(DO) concentration in the reactor. In a batch accumulation experiment with acetate,the PHA content achieved(28.5% CDW) was less than that of the pulse feeding strategy with the same amount of acetate(~2000 mg C/L). Using anaerobically treated and acidified brewery wastewater fed in pulses, the maximum PHA accumulated by the enriched MMC was similar for both wastewaters(45% CDW), in spite of the higher volatile fatty acid concentration in acidified brewery wastewater. The pulse feed addition controlled by the DO concentration was difficult to implement for wastewater as compared to acetate because the difference in DO concentration between substrate availability and depletion was low. For the batch addition of acidified wastewater, a slightly lower PHA content(39%CDW) was obtained. These results show that both brewery wastewaters can be utilized for PHA production with a similar maximum PHA storage capacity. | Pravesh Tamang Rintu Banerjee Stephan K?ster Regina Nogueira | 2019 | Journal of Environmental Sciences2019，31，4： | 5 |
| 4 | 基于小波变换和分形表达的绞股蓝药材质量评价方法研究显示文摘目的:建立绞股蓝药材的HPLC指纹图谱,采用分形理论与小波变换的方法进行指纹图谱的特征提取,利用相似度计算对绞股蓝药材进行质量评价。方法:用甲醇回流提取绞股蓝药材中的黄酮类成分,建立HPLC指纹图谱。将色谱响应信号进行小波分解,并用分形维数描述各小波基参量。以小波基分形参量为特征变量,对不同产地的绞股蓝药材进行相似度比较。结果:采用优化的提取与分析条件建立了绞股蓝药材的指纹图谱。各样品相对于参照品的相似度可有效的评价各种绞股蓝样品。结论:以小波基分形参量表达的色谱指纹图谱用于中药材的质量评价,相对于人工选择特征峰更具客观性。以小波基分形参量计算的相似度可以定性评价绞股蓝样品;浙江产绞股蓝药材可以作为陕西安康绞股蓝的替代药材。 | 刘芳 胡坪 Annika Küster 任德权 | 2008 | 中成药2008，30，10： | 5 |
| 5 | Demographic determinants of risk,colon distribution and density scores of diverticular disease显示文摘AIM:To investigate associations between ethnicity,age and sex and the risk,colon distribution and density scores of diverticular disease(DD).METHODS:Barium enemas were examined in 1000 patients:410 male,590 female;760 whites,62 Asians,44 black africans(BAs),and 134 other blacks(OBs).Risks and diverticula density of left-sided DD(LSDD) and rightsided-component DD(RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic regression.RESULTS:Four hundred and forty-seven patients had DD(322 LSDD and 125 RSCDD).Adjusted risks:(1) LSDD:each year increase in age increased the odds by 6%(95% CI:5-8,SE:0.8%,P < 0.001);Asians:odds ratio(OR):0.23(95% CI:0.10-0.53,SE:0.1,P ≤ 0.001) and OBs:OR:0.25(95% CI:0.14-0.43,SE:0.07,P ≤ 0.001) appeared protected vs Whites;(2) RSCDD:each year increase in age increased the odds by 4%(95% CI:2-6,SE:1%,P < 0.001);females were 0.60 times(95% CI:0.40-0.90,SE:0.12,P = 0.01) less likely than males to have RSCDD;BAs were 3.51 times(95% CI:1.70-7.24,SE:1.30,P < 0.001) more likely than Whites to have RSCDD;and(3) DD density scores:each year increase in age increased the odds of highdensity scores by 4%(95% CI:1-6,SE:1%,P < 0.001);RSCDD was 2.77 times(95% CI:1.39-3.32,SE:0.67,P < 0.001) more likely to be of high density than LSDD.No further signif icant differences were found in the adjusted models.CONCLUSION:Right colonic DD might be more common and has higher diverticula density in the west than previously reported.BAs appear predisposed to DD,whereas other ethnic differences appear conserved following migration. | Mark Golder Irina Chis Ster Pratusha Babu Amita Sharma Muhammad Bayat Abdulkadir Farah | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 6 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 7 | Recruitment in species-rich grasslands: the effects of functional traits and propagule pressure显示文摘Aims The assembly of plant communities is a complex process which combines impacts from the species pool,dispersal and propagule pressure,niche requirements of colonizing species and the niche structure of the community.Recent theory development has incorporated all these aspects,e.g.in‘stochastic niche theory’.We investigated recruitment into a species-rich grassland community,using an experimental approach where we manipulated the trait composition of the community and examined the success of colonizing species entering with various propagule pressure.Specifically,we examined two predictions:(i)colonization success increases with increasing difference between traits of the colonizing species and the trait profile of the community and(ii)colonization success increases with increasing propagule pressure.Methods The examined communities were species-rich semi-natural grasslands located in southern Sweden.After a careful documentation of the composition of the plant communities at the experimental sites,we manipulated the trait profile of species-rich grassland plots based on the plant functional trait specific leaf area(SLA),which is correlated with several key life history functions.In addition to SLA,seed mass was also used to describe the trait profile of grassland plots.Seeds of 12 plant species from the regional species pool,varying in SLA and seed mass,were sown into plots using four different levels of propagule pressure.Recruitment was examined after 1 year.We also planted juvenile‘plug plants’of the same species which allowed us to examine survivorship and growth beyond the seedling stage.Important Findings Overall we found very limited evidence for relationships between the traits of the colonizing species and the trait profile of the community and for recruitment after sowing these relationships were contrary to the prediction.Survival of plug plants after two seasons of growth was high irrespective of the trait profile of the community,but growth of plug plants was affected by the trait profile of the surrounding community.For four of the species there was a positive effect of increased propagule pressure on colonization.The results suggest that species assembly in species-rich grasslands is not strongly dependent on the niche structure of the community.However,the finding that colonization of only a third of the species responded positively to increased propagule pressure indicates that there might be niche-related effects that were not captured by our treatments.Overall,our results indicate that the factors determining colonization in this community are species specific.Some species are able to colonize irrespective of niche relationships,provided that the propagule pressure is sufficiently high to overcome stochastic mortality after seed arrival.For other species,however,we cannot exclude that niche assembly occurred,but we failed to identify the relevant niche factor. | MathiasÖster Ove Eriksson | 2012 | Journal of Plant Ecology2012，5，3： | 2 |
| 8 | Rapid,simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection显示文摘A rapid and simple method for the determination of polyhexamethylene biguanide(polyhexanide,PHMB)in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection(HPLC-DAD)was developed.Best separation was achieved using a cyanopropyl bonded phase(Agilent Zorbax Eclipse XDB-CN column 4.6 mm x 75 mm with particle size of 3.5μm)as well as gradient elution consisting of acetonitrile/deionized water at a flow rate of 1.0mL/min.The optimized and applied chromatographic conditions permitted separation of polyhexanide from interacting matrix with subsequent detection at a wavelength of 235 nm with good sensitivity.The method validation was carried out with regard to the guidelines for analytical procedures demanded by the International Conference on Harmonisation(ICH).Mean recoveries of 102%and 101%for gel-like as well as liquid preparations were obtained.Suitable repeatability as well as intermediate precision could be achieved with limits of detection≤0.004 mg/mL for both formulations,equivalent to≤0.004%PHMB concerning sample preparation.Determination of PHMB was accomplished without tedious sample preparation.Interacting matrix could be eliminated by the chromatographicprocedure with excellent performance of system suitability.All analytical requirements were fulfilled permitting a reliable and precise determination of PHMB in pharmaceuticals.Furthermore,the developed method was applied to stability testing of pharmaceutical preparations containing PHMB. | Markus Küsters Soren Beyer Stephan Kutscher Harald Schlesinger Michael Gerhartz | 2013 | Journal of Pharmaceutical Analysis2013，3，6： | 2 |
| 9 | Finite cell method compared to h-version finite element method for elasto-plastic problems显示文摘The finite cell method(FCM) combines the high-order finite element method(FEM) with the fictitious domain approach for the purpose of simple meshing. In the present study, the FCM is used to the Prandtl-Reuss flow theory of plasticity, and the results are compared with the h-version finite element method(h-FEM). The numerical results show that the FCM is more efficient compared to the h-FEM for elasto-plastic problems, although the mesh does not conform to the boundary. It is also demonstrated that the FCM performs well for elasto-plastic loading and unloading. | A.ABEDIAN J.PARVIZIAN A.DSTER E.RANK | 2014 | Applied Mathematics and Mechanics(English Edition)2014，35，10： | 2 |
| 10 | Mapping of quantitative trait loci determining agronomic important characters in hexaploid wheat (Triticum aestivum L.)显示文摘 | A. B?rner E. Schumann A. Fürste H. C?ster B. Leithold M. R?der W. Weber | 2002 | Theoretical and Applied Genetics (-)2002，，6： | 1 |
| 11 | Asymptotic growth of controlled Galton-Watson processes显示文摘 | Küster P | 1985 | Ann Probab1985，，13： | 1 |
| 12 | Superior mesenteric artery aneurysm stent graft显示文摘 | R. Drescher O. K?ster T. Rothenburg | 2006 | Abdominal Imaging2006，，1： | 1 |
| 13 | Advanced glycation end-products suppress neuropilin-1 expression in podocytes显示文摘 | Bondeva T Rüster C Franke S | 2009 | Kidney Int2009，75，6： | 1 |
| 14 | Safety of telmisartan in patients with arterial hypertension:an open-label observational study显示文摘 | MICHEL MC BOHNER H K(O)STER J | 2004 | Drug Saf2004，27，5： | 1 |
| 15 | Maximal strength-training effects on force-velocity and force-power relationships explain increases in aerobic performance in humans显示文摘 | STERS H HELGERUD J HOFF J | 2002 | Eur J Appl Physiol2002，88，3： | 1 |
| 16 | alpha5-integrin is crucial for LICAM-mediated chemoresistance in pancreatic adenocarcinoma显示文摘 | Sebens Müerk(o)ster S Kotteritzsch J Geismann C | | 0，，： | 1 |
| 17 | Anterior chamber and sutured posterior chamber in- traocular lenses in eyes with poor capsular support显示文摘 | Donaldson KE Gorscak J J Budenz DL Feuer W J Benz MS For- ster RK | 2005 | J Cata- ract Refract Surg2005，31，5： | 1 |
| 18 | Rituximab for the second-and third-line therapy of idiopathic membranous nephropathy:a prospective single center study using a new treatment strategy显示文摘 | Busch M Rüster C Schink(o)the C | | 0，，02： | 1 |
| 19 | Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors显示文摘 | Schwermer M Lee S K?ster J van Maerken T Stephan H Eggert A | 2015 | Oncotarget2015，6，15： | 1 |
| 20 | Benders Decom- position with Alternative Multiple Cuts for a Muhi-produet Closed-loop Supply Chain Network Design Model显示文摘 | STER H EASWARAN G AK ALl E | 2007 | Nay Res Logist2007，54，6： | 1 |
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