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| 1 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S Brown EJ Banerjee RR Wright CM Patel HR Ahima RS Lazar MA | | 0，，： | 6 |
| 2 | Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion显示文摘AIM To examine the role that enzyme Acyl-CoA:diacylglycerol acyltransferase-1(DGAT1) plays in postprandial gut peptide secretion and signaling.METHODS The standard experimental paradigm utilized to evaluate the incretin response was a lipid challenge.Following a lipid challenge,plasma was collected via cardiac puncture at each time point from a cohort of 5-8 mice per group from baseline at time zero to 10 h.Incretin hormones [glucagon like peptide-1(GLP-1),peptide tyrosine-tyrosine(PYY) and glucose dependent insulinotropic polypeptide(GIP)] were then quantitated.The impact of pharmacological inhibition of DGAT1 on the incretin effect was evaluated in WT mice.Additionally,a comparison of loss of DGAT1 function either by genetic ablation or pharmacological inhibition.To further elucidate the pathways and mechanisms involved in the incretin response to DGAT1 inhibition,other interventions [inhibitors of dipeptidyl peptidase-IV(sitagliptin),pancreatic lipase(Orlistat),GPR119 knockout mice] were evaluated.RESULTS DGAT1 deficient mice and wildtype C57/BL6J mice werelipid challenged and levels of both active and total GLP-1 in the plasma were increased.This response was further augmented with DGAT1 inhibitor PF-04620110 treated wildtype mice.Furthermore,PF-04620110 was able to dose responsively increase GLP-1 and PYY,but blunt GIP at all doses of PF-04620110 during lipid challenge.Combination treatment of PF-04620110 and Sitagliptin in wildtype mice during a lipid challenge synergistically enhanced postprandial levels of active GLP-1.In contrast,in a combination study with Orlistat,the ability of PF-04620110 to elicit an enhanced incretin response was abrogated.To further explore this observation,GPR119 knockout mice were evaluated.In response to a lipid challenge,GPR119 knockout mice exhibited no increase in active or total GLP-1 and PYY.However,PF-04620110 was able to increase total GLP-1 and PYY in GPR119 knockout mice as compared to vehicle treated wildtype mice.CONCLUSION Collectively,these data provide some insight into the mechanism by which inhibition of DGAT1 enhances intestinal hormone release. | Benjamin S Maciejewski Tara B Manion Claire M Steppan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，4： | 2 |
| 3 | The hormone resistin links obesity to diabetes显示文摘 | Steppan C M Bailey S T Bhat S | 2001 | Nature2001，409，： | 1 |
| 4 | The hormone resistin links obesity to diabetes显示文摘 | STEPPAN C M BAILEY S T BHAT S | 2001 | Nature2001，409，： | 1 |
| 5 | The hormone resistin links obesity to diabetes显示文摘 | STEPPAN CM BAILEY ST BHAT S | 2001 | Nature2001，409，18： | 1 |
| 6 | A family of tissue-specific resistin-like molecules显示文摘 | Steppan C M Brown E J Wright C M | 2001 | Proc Natl Acad Sci USA2001，98，2： | 1 |
| 7 | The hormone resistin links obesity to diabetes 显示文摘 | STEPPAN C M BAILEY S T BHAT S | 2001 | Nature2001，409，： | 1 |
| 8 | The hormone resistin links obe-sity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，： | 1 |
| 9 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 10 | The hormone resistin links obesity to diabeles 显示文摘 | Bailey S T Bhat S | 2001 | Nature2001，400，： | 1 |
| 11 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 12 | Molecular phylogeny of the marmots (rodentia: Sci- uridae): Tests of evolutionary and biogeographic hypotheses 显示文摘 | STEPPAN S J AKHVERDYAN M R LYAPUNOVA E A et ol | 1999 | Syst Biol1999，48，4： | 1 |
| 13 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 14 | The hormone resistin links obesity to diabetes 显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 15 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 16 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 17 | The hormone resistin links obesity to diabetes显示文摘 | STEPPAN C M BAILEY S T BHAT S | 2001 | Nature2001，409，： | 1 |
| 18 | The hormone resistin links o- besity to diabetes 显示文摘 | Steppan CM Bailey ST Bhat S | 2001 | Nature2001，409，6818： | 1 |
| 19 | A metaanalysis of theeffective- hess and safety of ozone treatments for herniated lum - bar discs显示文摘 | Steppan J Meaders T Muto M | 2010 | J Vase Interv Radiol2010，21，4： | 1 |
| 20 | Antagonism of insulin action by resistin显示文摘 | Steppan C Yamazawa T Brown E J | | 0，，2： | 1 |
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