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| 1 | Insights into Cronobacter sakazakii Biofilm Formation and Control Strategies in the Food Industry显示文摘Cronobacter sakazakii(C.sakazakii)is a foodborne opportunistic pathogen that can cause life-threatening invasive diseases,such as necrotizing enterocolitis,meningitis,and sepsis in infants.The potential risk of C.sakazakii contamination of powdered infant formula(PIF)is an issue that has attracted considerable attention from manufacturers,regulators,and consumers.C.sakazakii biofilms on the surfaces of equipment and in diverse food-production environments constitute a mode of cell growth that protects the pathogen from hostile environments,and are an important source of persistent contamination of food products.Bacterial biofilms are difficult to remove due to their resistant properties.Conventional cleaning and sterilizing procedures may be insufficient for biofilm control,and may lead to further biofilm development and dispersal.Consequently,novel control strategies are being developed,such as nanotechnology-based delivery systems,interspecies interactions,antimicrobial molecules of microbial origin,natural extracts,and phages.This review focuses on describing the mechanisms underlying the biofilm formation and behavior of C.sakazakii and discussing potential control strategies. | Na Ling Stephen Forsythe Qingping Wu Yu Ding Jumei Zhang Haiyan Zeng | 2020 | Engineering2020，6，4： | 10 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | Food Safety Risks and Contributing Factors of Cronobacter spp.显示文摘Cronobacter species are a group of Gram-negative opportunistic pathogens,which cause meningitis,sep-ticemia,and necrotizing enterocolitis in neonates and infants,with neurological sequelae in severe cases.Interest in Cronobacter has increased significantly in recent years due to its high virulence in children.In this review,we summarize the current understanding of the prevalence of Cronobacter species in several important food types.We discuss the response mechanisms enabling persistence in adverse growth con-ditions,as well as its pathogenicity.We emphasize the food safety concerns caused by Cronobacter and subsequent control methods and clinical treatments. | Na Ling Xiuting Jiang Stephen Forsythe Danfeng Zhang Yizhong Shen Yu Ding Juan Wang Jumei Zhang Qingping Wu Yingwang Ye | 2022 | Engineering2022，8，5： | 2 |
| 4 | Association mapping in structured popula-tions显示文摘 | PRITCHARD J K STEPHENS M ROSENBERG NA | 2000 | Am J Hum Genet2000，67，1： | 1 |
| 5 | HRT and everyday memory at menopause:a comparison of two samples of mid-aged women显示文摘 | Stephens C Bristow V Pachana NA | 2006 | Women Health2006，43，1： | 1 |
| 6 | ELISA determinination of soluble urokinase receptor in blood from healthy donors and cancer patients显示文摘 | Stephens RW Pedersen NA Melsen HJ | 1997 | Clin Chem1997，43，10： | 1 |
| 7 | Evaluating potential biomarkers of caehexia and survival in skeletal muscle of upper gastrointestinal eaneer patients 显示文摘 | Stephens NA Skil?worth RJ Gallagher IJ | 2015 | J Caehexia Sarcopenia Muscle2015，6，1： | 1 |
| 8 | Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome insequential human muscle biopsies显示文摘 | Gallagher IJ Stephens NA MacDonald AJ | 2012 | Clin Canc- er Res2012，18，10： | 1 |
| 9 | Ten questions concerning future buildings beyond zero energy and carbon neutrality显示文摘Architects and planners have been at the forefront of envisioning a future built environment for millennia. How ever,fragmental view s that emphasize one facet of the built environment,such as energy,environment,or groundbreaking technologies,often do not achieve expected outcomes. Buildings are responsible for approximately one-third of w orldw ide carbon emissions and account for about 40% of primary energy consumption in the U. S. In addition to achieving the very ambitious goal of reducing building-associated greenhouse gas emissions by75% by 2050,buildings must improve their functionality and performance to meet current and future human,societal,and environmental needs in a changing w orld. In this article,w e introduce a new framew ork to guide potential evolution of the building stock in the next century,based on greenhouse gas emissions as the common thread to investigate the potential implications of new design paradigms,innovative operational strategies,and disruptive technologies. This framew ork emphasizes integration of multidisciplinary know ledge,scalability for mainstream buildings,and proactive approaches considering constraints and unknow ns.The framew ork integrates the interrelated aspects of the built environment through a series of quantitative metrics that aim to improve environmental outcomes w hile optimizing building performance to achieve healthy,adaptive,and productive buildings. | Na Wang Patrick E. Phelan Jorge G onzalez Chioke Harris G regor P. Henze Robert Hutchinson Jared Langevin Mary Ann Lazarus Brent Nelson Chris Pyke Kurt Roth David Rouse Karma Sawyer Stephen Selkowitz 侯恩哲 | 2017 | 建筑节能2017，45，7： | 1 |
| 10 | Therelationship between hospital volume and post-operativemortality rates for upper gastrointestinal cancerresections : Scotland 1982 2003 显示文摘 | Skipworth RJ Parks RW Stephens NA | 2010 | Eur J Surg Oncol2010，36，2： | 1 |
| 11 | Association mapping in structured population显示文摘 | Pritchard JK Stephens M Rosenberg NA Dormelly P | 2000 | Am J Hum Genet2000，67，： | 1 |
| 12 | Cachexia, survival and the acute phase response 显示文摘 | Stephens NA Skipworth RJ Fearon KC | 2008 | Curr Opin Support Palliat Care2008，2，4： | 1 |
| 13 | Glutamine repeat vari- ants in human RUNX2 assoeiated with decreased femoral neck BMD,broadband ultrasound attenuation and target gene transacti- ration显示文摘 | Morrison NA Stephens AA Osato M | 2012 | PLoS One2012，7，42： | 1 |
| 14 | Association mapping in structured populations显示文摘 | Pritchard JK Stephens M Rosenberg NA | 2000 | Am J Hum Genet2000，67，： | 1 |
| 15 | A review of allochthonous organic matter dynamics and metabolism in streams 显示文摘 | Tank JL Rosi-Marshall EJ Griffiths NA Entrekin SA Stephen ML | 2010 | N Am Benthol Soc2010，29，1： | 1 |
| 16 | A quantitative study of gene regulation involved in the immune response of anopheline mosquitoes: an application of bayesian hierarchical clustering of curves显示文摘 | Heard NA Holmes CC Stephens DA | 2006 | Journal of the American Statistical Association2006，101，： | 1 |
| 17 | Tissue and regional expression patterns of dicistronic tRNA–mRNA transcripts in grapevine (Vitis vinifera) and their evolutionary co-appearance with vasculature in land plants显示文摘Transfer RNAs(tRNA)are crucial adaptor molecules between messenger RNA(mRNA)and amino acids.Recent evidence in plants suggests that dicistronic tRNA-like structures also act as mobile signals for mRNA transcripts to move between distant tissues.Co-transcription is not a common feature in the plant nuclear genome and,in the few cases where polycistronic transcripts have been found,they include non-coding RNA species,such as small nucleolar RNAs and microRNAs.It is not known,however,the extent to which dicistronic transcripts of tRNA and mRNAs are expressed in field-grown plants,or the factors contributing to their expression.We analysed tRNA–mRNA dicistronic transcripts in the major horticultural crop grapevine(Vitis vinifera)using a novel pipeline developed to identify dicistronic transcripts from high-throughput RNA-sequencing data.We identified dicistronic tRNA–mRNA in leaf and berry samples from 22 commercial vineyards.Of the 124 tRNA genes that were expressed in both tissues,18 tRNA were expressed forming part of 19 dicistronic tRNA–mRNAs.The presence and abundance of dicistronic molecules was tissue and geographic sub-region specific.In leaves,the expression patterns of dicistronic tRNA–mRNAs significantly correlated with tRNA expression,suggesting that their transcriptional regulation might be linked.We also found evidence of syntenic genomic arrangements of tRNAs and protein-coding genes between grapevine and Arabidopsis thaliana,and widespread prevalence of dicistronic tRNA–mRNA transcripts among vascular land plants but no evidence of these transcripts in non-vascular lineages.This suggests that the appearance of plant vasculature and tRNA–mRNA occurred concurrently during the evolution of land plants. | Pastor Jullian Fabres Lakshay Anand Na Sai Stephen Pederson Fei Zheng Alexander A.Stewart Benjamin Clements Edwin R.Lampugnani James Breen Matthew Gilliham Penny Tricker Carlos M.Rodriguez Lopez Rakesh David | 2021 | Horticulture Research2021，8，1： | 0 |
| 18 | Vitamin A supplementation downregulates ADH1C and ALDH1A1 mRNA expression in weaned beef calves显示文摘Our previous studies demonstrated that oral vitamin A supplementation during late-stage pregnancy and the neonatal stage enhances birth weight,growth performance,and mRNA expression related to muscle and preadipocyte development in beef cattle.The alcohol dehydrogenase 1C(ADH1C)c.-64T>C genotype also correlated with vitamin A concentration in beef production.This study aimed to investigate the effects of vitamin A supplementation on the muscle development and vitamin A metabolism in weaned beef calves with different ADH1C genotypes.Twenty male calves(90 d of age;initial BW:89.03 kg[SD 8.60])were stratified according to ADH1C genotype and vitamin A treatment(duration:3 months)and randomly assigned to 4 groups with a 22 factorial arrangement.Vitamin A treatments included the following:control(10,000 IU/kg of as-fed,a.TT type;b.TC type);treatment(40,000 IU/kg of as-fed,c.TT type;and d.TC type).Parameters including BW,FI,blood,longissimus dorsi muscle,and liver status during the experimental period were analyzed using the generalized linear model(GLM)procedure and Tukey's test by SAS 9.4 program.Serum vitamin A was significantly increased(P<0.05)in the vitamin A treatment group at 4 and 6 months of age.TT type calves showed higher serum vitamin A concentration(P<0.05)than the TC type calves.Serum triglyceride and non-esterified fatty acid(NEFA)levels increased(P<0.05)in the treatment group compared with the control at 6 months of age.However,BW,ADG and FI showed no differences between the groups.In addition,mRNA expression in longissimus dorsi muscle revealed upregulation of paired box 7(PAX7)(P<0.05)after the vitamin A treatment period based on biopsy results.Both ADH1C and aldehyde dehydrogenase(ALDH)1A1 mRNA expression was downregulated(P<0.01)by vitamin A supplementation.The TC type of ADH1C showed higher mRNA expression than the TT type.However,no effect was observed on adipogenic mRNA expression(preadipocyte factor-1[PREF-1],peroxisome proliferator-activated receptor gamma[PPARg],fatty acid binding protein 4[FABP4])in all groups.Our findings suggest that weaned calves treated with vitamin A may promote the storage of satellite cells by elevating PAX7 gene expression in the muscle.The TC type calves may show increased capacity for vitamin A metabolism,which can be used in genetically customizing feed management to maximize beef production in the calves. | Xue Cheng Jin Dong Qiao Peng Seong Jin Kim Na Yeon Kim Jalil Ghassemi Nejad Danil Kim Stephen B.Smith Hong Gu Lee | 2022 | Animal Nutrition2022，，3： | 0 |
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