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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 3 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 4 | 脑部磁共振白质高信号的临床重要性:系统性综述和荟萃分析(摘要)显示文摘目的 回顾与卒中、认知功能衰退、痴呆和死亡风险相关的脑白质高信号的证据。
设计 系统性回顾和荟苇分析。
数据来源 从1966年至2009年11月23日PubMed数据库。 | Stephanie Debette H S Markus 廖怡(译) 李飞(译) 龚启勇(校) 付诗琴(校) | 2010 | 英国医学杂志中文版2010，13，6： | 5 |
| 5 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 6 | Evolution of Siderian juvenile crust to Rhyacian high Ba-Sr magmatism in the Mineiro Belt, southern S?o Francisco Craton显示文摘Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was added to the continental crust. Rocks mostly belong to the calc-alkaline series, meta-to peraluminous and originally 'Ⅰ-type',meaning that oxidized magmas were formed by partial melting of subducted material. The temporal distribution and apparent secular changes of the magmas are consistent with the onset of subduction-driven plate tectonics due to an increase of the subduction angle and opening of the mantle wedge. New isotopic analyses(Sm-Nd whole rock and Lu-Hf in zircon)corroborate the restricted juvenile nature of the Mineiro Belt and confirm the genetic link between the Lagoa Dourada Suite,a rare ca. 2350 Ma high-Al tonalite-trondhjemite magmatic event, and the sanukitoid-type ca. 2130 Ma Alto Maranhao Suite. U-Pb dating of zircon and titanite constrain the crystallisation history of plutonic bodies; coupled with major and trace element analyses of the host rocks, they distinguish evolutionary trends in the Mineiro Belt. Several plutons in the region have ages close to 2130 Ma but are distinguished by the lower concentration of compatible elements in the juvenile high Ba-Sr suite. | Hugo Moreira Luís Seixas Craig Storey Mike Fowler Stephanie Lasalle Ross Stevenson Cristiano Lana | 2018 | Geoscience Frontiers2018，9，4： | 3 |
| 7 | Interarch tooth size relationships of 3 populations:does Bolton's analysis apply显示文摘 | Stephanie S Peter H Etasuko W | 2000 | Am J Orthod Dentofac Orthop2000，117，2： | 1 |
| 8 | Unique case of presumed lisinopril-induced hepatotoxicity显示文摘 | Sandip KZ Saurabh S Stephanie L | 2010 | Am J Health- Syst Pharm2010，67，16： | 1 |
| 9 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 10 | Global metabolic profiling of Escherichia coli cultures : an evaluation of methods for quenching and extraction of intracellular metabolites 显示文摘 | Catherine LW Warwick BD Stephanie S | 2008 | Anal Chem2008，80，8： | 1 |
| 11 | PEGASIS:Power Efficient Gathering in Sensor Information Systems显示文摘 | Stephanie Lindsey Cauligi S Raghavendra | 2002 | IEEE Aerospace Conference Proceedings2002，3，3： | 1 |
| 12 | High - resolu-tion profiling of fetal DNA clearance from maternal plasma by mas-sively parallel sequencing显示文摘 | STEPHANIE C Y LEE S W Y JIANG P | 2013 | Clin Chem2013，59，8： | 1 |
| 13 | Foot ulcers in the diabetic patient, prevention and treatment显示文摘 | Stephanie C Vickie R James S | 2007 | Vascular Health Risk Manag2007，3，1： | 1 |
| 14 | Measurement,analysis,and display of haptic signals during surgical cutting 显示文摘 | Stephanie G V H Vanessa C A O Thomas S | 2002 | Presence2002，11，6： | 1 |
| 15 | 显示文摘 | Stephanie V Isabel P S Jorge P J | 2007 | Langmuir2007，23，： | 1 |
| 16 | A Pre-regularization Scheme for the Reconstruction of a Spatial Dependent Scattering Albedo Using a Hybrid Ant Colony Optimization Implementation显示文摘 | Stephany S Becceneri J C Souto R P | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 17 | Interrelationships between biological, chemical, and physical processes as an analog to clogging in aquifer storage and recovery(ASR)wells显示文摘 | Stephanie R Santo R Pascale S | 2000 | Water Resources2000，34，7： | 1 |
| 18 | Integrating a wavelet based perspiration liveness check with fingerprint recognition 显示文摘 | Abhyankar A Stephanie S | 2009 | Pattern Recognition2009，42，3： | 1 |
| 19 | Linking advertising and quantity decisions in the single-period inventory model显示文摘 | Khouja M Stephanie S R | 2003 | International Journal of Production Economics2003，86，： | 1 |
| 20 | Chemical surface reactions by click chemistry:coumarin dye modification of 11-bromoundecyltrichlorosilane monolayers显示文摘 | Claudia Haensch Stephanie Hoeppener Ulrich S Schubert | 2008 | Nanotechnology2008，19，3： | 1 |
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