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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Pulmonary adrenomedullin Counteracts deterioration of coronary flow and myocardial performance evoked by pulmonary endothelins in experimental acute respiratory distress syndrome显示文摘 | STANGL K LAULE M RICHTER C | 2001 | Crit Care Med2001，29，5： | 2 |
| 3 | Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics显示文摘Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global optimum.Herein,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box optimization.Our Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical solvers.With the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the experimentalist.As a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods. | Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi | 2020 | npj Computational Materials2020，，1： | 2 |
| 4 | The role of tea and tea flavonoids in cardiovascular health显示文摘 | STANGL V LORENZ M STANGL K | 2006 | Mol Nutr Food Res2006，50，： | 1 |
| 5 | Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases显示文摘 | Jochmann N Stangl K Garbe E | 2005 | Eur Heart J2005，26，16： | 1 |
| 6 | Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty显示文摘 | Mueller MR Salat A Stangl P | 1997 | Thromb Haemost1997，78，3： | 1 |
| 7 | 显示文摘 | Ferber J Stangl R Luther J | 1998 | Solar Energy Materials and Solar Cells1998，53，12： | 1 |
| 8 | The role of tea and tea flavonoids in cardiovascular health 显示文摘 | Stangl V Lorenz M Stangl K | 2006 | Mol Nutr Food Res2006，50，2： | 1 |
| 9 | Rituximab and alemtuzumabinduce a nonclassic,caspase independent apoptic pathway in lymphoid cell lines and in chronic lymphocytic leukemiacells显示文摘 | Stangl maier M Reis S Hallek M | 2004 | Ann Hematol2004，83，10： | 1 |
| 10 | Secretory products from human adipocytes impair endothelial function via nuclear factorkappaB显示文摘 | Kralisch S Sommer G Stangl V | 2008 | Atherosclerosis2008，196，2： | 1 |
| 11 | Factors influ- encing the natural history of colorectal liver metastases 显示文摘 | Stangl R Ahendorf-Hofmann A Chamely RM | 1994 | Lancet1994，343，3： | 1 |
| 12 | Successful orthotopic small bowel transplantation with short-term FK 506 immunosuppressive therapy显示文摘 | Stangl MJ Todo S | 1990 | Transplant Proc1990，22，1： | 1 |
| 13 | Inhibition of the Ubiquitin-Proteasome Pathway Induces Differential Heat-Shock Protein Response in Cardiomyocytes and Renders Early Cardiac Protection显示文摘 | Stangl K Gunther C Frank T | 2002 | Biochem Biophys Res Commun2002，291，3： | 1 |
| 14 | Factors influencing the natural history of colorectal liver metastases显示文摘 | Stangl R Altendorf-Hofman A Chamley RM | 1994 | Lancet1994，343，： | 1 |
| 15 | Successful treatment of thromboangiitis obliterans (Buerger's disease) with immunoadsorption: resultsof a pilot study显示文摘 | Gert Baumann Verena Stangl Peter Klein-Weigel | 2011 | Clin Res Cardiol2011，100，20： | 1 |
| 16 | Intrinsic tumors of the insula: a prospective surgical study of 30 patients 显示文摘 | Zentner J Meyer B Stangl A | 1996 | J Neurosurg1996，85，2： | 1 |
| 17 | Field use and calibration of a TDR-based probe for monitoring water content in a high-clay landslide soil in Austria显示文摘 | Stangl R Buchan G D Loiskandl W | 2009 | Geoderma2009，150，12： | 1 |
| 18 | Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty显示文摘 | Salat A Stangl P | 1997 | Thromb Haemost1997，78，： | 1 |
| 19 | A micromechanistic model of microstructure development during the combustion synthesis process 显示文摘 | Zhang Yangsheng Gregory C Stangle | 1995 | J Mater Res1995，10，4： | 1 |
| 20 | 显示文摘 | Jiang S Schulze W A Stangle G C | 1997 | J Mater Res1997，12，： | 1 |
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