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| 1 | Current and future therapies for inherited cholestatic liver diseases显示文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases. | Wendy L van der Woerd Roderick HJ Houwen Stan FJ van de Graaf | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 2 | Inverse design of metasurfaces with non-local interactions显示文摘Conventional metasurfaces have demonstrated efficient wavefront manipulation by using thick and high-aspect-ratio nanostructures in order to eliminate interactions between adjacent phase-shifter elements.Thinner-than-wavelength dielectric metasurfaces are highly desirable because they can facilitate fabrication and integration with both electronics and mechanically tunable platforms.Unfortunately,because their constitutive phase-shifter elements exhibit strong electromagnetic coupling between neighbors,the design requires a global optimization methodology that considers the non-local interactions.Here,we propose a global evolutionary optimization approach to inverse design non-local metasurfaces.The optimal designs are experimentally validated,demonstrating the highest efficiencies for the thinnest transmissive metalenses reported to-date for visible light.In a departure from conventional design methods based on the search of a library of pre-determined and independent meta-atoms,we take full advantage of the strong interactions among nanoresonators to improve the focusing efficiency of metalenses and demonstrate that efficiency improvements can be obtained by lowering the metasurface filling factors. | Haogang Cai Srilok Srinivasan David A.Czaplewski Alex B.F.Martinson David J.Gosztola Liliana Stan Troy Loeffler Subramanian K.R.S.Sankaranarayanan Daniel López | 2020 | npj Computational Materials2020，，1： | 2 |
| 3 | Heap leaching of Pb and Zn contaminated soilusing ozone/UV treatment of EDTA extraetants 显示文摘 | Fiitzgar N L$stan D | 2006 | Chemosphere2006，63，10： | 1 |
| 4 | Risk Filtering, Ranking, and Management Framework Using Hierarchical Holographic Modeling 显示文摘 | YACOV Y H STAN K JAMES H L | 2002 | Risk Analysis2002，22，2： | 1 |
| 5 | Dyspnea perception in COPD:association between anxiety,dyspnea-related fear,and dyspnea in a pulmonary rehabilitation program 显示文摘 | Janssens T De Peuter S Stans L | 2011 | Chest2011，140，3： | 1 |
| 6 | Strctural and optical properties of ZnO thinfilms by rf magnetron sputtering woth rapid thermal annealing显示文摘 | Suvorova N A Usov I O Stan L | 2008 | ApplPh- ysLett2008，92，14： | 1 |
| 7 | Clinical trial and post-licensure safety profile of a prophylactic human papillomavirus(Types 6,11,16,and 18) L1 virus-like particle vaccine显示文摘 | Stan L Darron R Archana B | 2010 | The Pediatric Infectious Disease Journal2010，29，2： | 1 |
| 8 | Decentralised minimum-time con- sensus 显示文摘 | Yuan Y Stan G Shi L | 2013 | Automatica2013，49，5： | 1 |
| 9 | The impact of a state- wide training to increase child care providers' knowledge of nutrition and physical activity rules in Delaware 显示文摘 | Van Stan S Lessard L Dupont P K | 2013 | Child Obes2013，9，1： | 1 |
| 10 | 显示文摘 | Suvorova N A Usov I O Stan L | 2008 | J Appl Phys2008，92，14： | 1 |
| 11 | 显示文摘 | Kang B S Jang-Sik L Stan L | 2004 | Applied Physics Letters2004，85，： | 1 |
| 12 | Clinical Trial and Post-Licensure safety profile of a prophylactic human papillomavirus (Types 6, 11, 16, and 18) L1 virus-like particle vaccine显示文摘 | Stan L Darron R Archana B | 2010 | The Pediatric Infectious Disease Journal2010，29，2： | 1 |
| 13 | Structural and optical properties of ZnO thin films by RF magnetron sputtering with rapid thermal annealing 显示文摘 | SUVOROVA N A USOV I O STAN L | 2008 | Appl Phys Lett2008，92，14： | 1 |
| 14 | Once-daily atomoxetine for treating pediatric attentiondeficit/hyperactivity disorder:comparison of morning and evening dosing显示文摘 | STAN L BLOCK DOUGLAS KELSEY DANIEL COURY | 2009 | Clinical Pediatrics2009，48，7： | 1 |
| 15 | Survival in patients with HIV infection and viral hepatitis B or C: a cohort study显示文摘 | Maurizio B Stan L Natalie B | 2004 | AIDS2004，18，15： | 1 |
| 16 | Support vector machines face recognition显示文摘 | Guo G D Stan Z L Kap L C | 2001 | Image and Computer2001，19，4： | 1 |
| 17 | Structural and optical properties of ZnO thin films by RF magnetron sputtering with rapid thermal annealing显示文摘 | SUVOROVA N A USOV I O STAN L | 2008 | APL2008，92，14： | 1 |
| 18 | Aurora: A new model and architecture for data stream management显示文摘 | Daniel JA Don C Ugur C Mitch C Christian C Sangdon L Michael S Nestime T Stan Z | 2003 | The Int'' 1 Journal on Very Large Data Bases2003，12，2： | 1 |
| 19 | Learning muhiview face subspaces and facial pose estimation using independent component analysis 显示文摘 | STAN Z L LOU X G HOU X W | 2005 | IEEE Transactions on Image Processing2005，14，6： | 1 |
| 20 | The synthetic hierarchy method: An optimizing approach to obtaining priorities in the AHP显示文摘 | Stan L | 1996 | European Journal of Operational Research1996，93，3： | 1 |
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