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| 1 | Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C显示文摘BACKGROUND: Liver steatosis and iron overload, which are frequently observed in chronic hepatitis C (CHC), may contribute to the progression of liver injury. This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to non- alcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients. METHODS: A total of 191 CHC patients were compared with 67 NAFLD and 21 HH patients. Liver function tests, serum markers of iron metabolism, cholesterol and triglycerides were assayed. The inflammatory activity, fibrosis, iron deposits and steatosis stages were assessed in liver specimens. HFE gene polymorphisms were investigated by PCR-RFLP. RESULTS: Liver steatosis was associated with obesity and diabetes mellitus. This disease was confirmed in 76/174 (44%) CHC patients, most of whom were infected with genotype 1. The average grade of steatosis was higher in NAFLD patients. CHC patients had significantly higher iron concentrations and transferrin saturations than NAFLD patients. Compared with CHC patients, HH patients had higher values of serum iron parameters and more intensive hepatocyte iron deposits without differences in the prevalence and intensity of liver steatosis. In the CHC group, lipids accumulation in hepatocytes was significantly associated with the presence of serummarkers of iron overload. No correlation between the HFE gene polymorphism and liver steatosis in CHC patients was found. CONCLUSIONS: Liver steatosis was diagnosed in nearly half of CHC patients, most of whom were infected with genotype 1. The intensity of steatosis was lower in CHC patients than that in NAFLD patients because of a less frequent diagnosis of metabolic syndrome. Only in CHC patients were biochemical markers of iron accumulation positively correlated with liver steatosis; these findings were independent of HFE gene mutations. | Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Robert Rzepko Krzysztof Piotr Bielawski | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 2 |
| 2 | Iron overload and HFE gene mutations in Polish patients with liver cirrhosis显示文摘BACKGROUND:Increased liver iron stores may contribute to the progression of liver injury and fibrosis,and are associated with a higher risk of hepatocellular carcinoma development.Pre-transplant symptoms of iron overload in patients with liver cirrhosis are associated with higher risk of infectious and malignant complications in liver transplant recipients.HFE gene mutations may be involved in the pathogenesis of liver iron overload and influence the progression of chronic liver diseases of different origins.This study was designed to determine the prevalence of iron overload in relation to HFE gene mutations among Polish patients with liver cirrhosis.METHODS:Sixty-one patients with liver cirrhosis included in the study were compared with a control group of 42 consecutive patients subjected to liver biopsy because of chronic liver diseases.Liver function tests and serum iron markers were assessed in both groups.All patients were screened for HFE mutations (C282Y,H63D,S65C).Thirty-six of 61 patients from the study group and all controls had liver biopsy performed with semiquantitative assessment of iron deposits in hepatocytes.RESULTS:The biochemical markers of iron overload and iron deposits in the liver were detected with a higher frequency (70% and 47% respectively) in patients with liver cirrhosis.There were no differences in the prevalence of all HFE mutations in both groups.In patients with a diagnosis of hepatocellular carcinoma,no significant associations with iron disorders and HFE gene mutations were found.CONCLUSIONS:Iron disorders were detected in patients with liver cirrhosis frequently but without significant association with HFE gene mutations.Only the homozygous C282Y mutation seems to occur more frequently in the selected population of patients with liver cirrhosis.As elevated biochemical iron indices accompanied liver iron deposits more frequently in liver cirrhosis compared to controls with chronic liver disease,there is a need for more extensive studies searching for the possible influence of non-HFE iron homeostasis regulators and their modulation on the course of chronic liver disease and liver cirrhosis. | Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Ewa Izycka-Swieszewska Krzysztof Piotr Bielawski | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 2 |
| 3 | Time-The next source of competitive advantage显示文摘 | George Stalk JR | 1988 | Harvard Biusiness Review1988，，： | 1 |
| 4 | Autoimmune reactions in HBV and HCV 显示文摘 | Michalska Z Stalke P Witczak-Mallnowska K | 2001 | Med Sci Monit2001，7，1： | 1 |
| 5 | Time-the next source of competitive advantage 显示文摘 | Stalk G J | 1988 | Harvard Business Review1988，66，4： | 1 |
| 6 | Time-the Next Source of Competition Advantage显示文摘 | Stalk G | 1988 | Harvard Business Review1988，，4： | 1 |
| 7 | Time-based competition and beyond: Competing on capabilities显示文摘 | Stalk G | 1992 | Planning Review1992，，20： | 1 |
| 8 | Time-the Next source of Competitive Advantage显示文摘 | Stalk G Jr | 1988 | Harvard Business Review1988，66，4： | 1 |
| 9 | Japang dark side of time 显示文摘 | STALK JR G WEBBER A M | 1993 | Harvard Business Review1993，71，4： | 1 |
| 10 | Synthese und Reaktivitat von Diphenyl phosphany Itrimethylsilylamin Ph2PN (H)SiMe 3 显示文摘 | WINGERTER S PFEIFFER M BAIER F STEY T STALKE D | 2000 | Z Anorg Allg Chem2000，626，： | 1 |
| 11 | Detection of Helicobacter species in liver and stomach tissues of patients with chronic liver disease using polymerase chain reaction, denaturing gradient gel electrophoresis and immunohistochemistry 显示文摘 | Stalke P AI-Soud WA Bielawski KP | 2005 | Scand JGastroenterol2005，40，9： | 1 |
| 12 | The Myth of the Horizontal Organization显示文摘 | Stalk G | 1994 | Canadian Business Review1994，214，： | 1 |
| 13 | G Time:The Next Source of Competitive Advantage显示文摘 | STALK Jr | 1988 | Harvard Business Review1988，66，4： | 1 |
| 14 | Euroeapitalism - advanta- ges and disadvantages 显示文摘 | STALK G EVANS P SHULMAN L E | 1992 | Hatcard Business Review1992，70，5： | 1 |
| 15 | Time-the next source of competitive advantage 显示文摘 | Stalk Jr G | 1988 | Harvard Business Review1988，66，： | 1 |
| 16 | Struktur Von 2 (Cp^* = η^5 - pentamethylcyclopemadienyl) 显示文摘 | STEINER A GORNITZKA H STALKE D | 1992 | J Organomet Chem1992，431，： | 1 |
| 17 | Time-the next source of competitive advantage显示文摘 | Stalk G | 1988 | Harvard Business Review1988，66，4： | 1 |
| 18 | Competing on ca-pabilities: the new rule of corporate strategy 显示文摘 | STALK G P EVANS L E SCHULMAN | 1992 | HarvardBusiness Review1992，，4： | 1 |
| 19 | Time-the next source of competitive advantage显示文摘 | Stalk G J | 1988 | Harvard Business Review1988，66，4： | 1 |
| 20 | Competing on capabilities: the new rules of Corporate strategy 显示文摘 | Stalk G | 1992 | Harvard Business Review1992，，70： | 1 |
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