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| 1 | The VEGF signaling pathway in cancer: the road ahead显示文摘The vascular endothelial growth factor (VEGF) family of soluble protein growth factors consists of key mediators of angiogenesis and lymphangiogenesis in the context of tumor biology. The members of the family, VEGF-A (also known as VEGF), VEGF-B, VEGF-C, VEGF-D, and placenta growth factor (PlGF), play important roles in vascular biology in both normal physiology and pathology. The generation of a humanized neutralizing antibody to VEGF-A (bevacizumab, also known as Avastin) and the demonstration of its benefit in numerous human cancers have confirmed the merit of an anti-angiogenesis approach to cancer treatment and have validated the VEGF-A signaling pathway as a therapeutic target. Other members of the VEGF family are now being targeted, and their relevance to human cancer and the development of resistance to anti-VEGF-A treatment are being evaluated in the clinic. Here, we discuss the potential of targeting VEGF family members in the diagnosis and treatment of cancer. | Steven A. Stacker Marc G. Achen | 2013 | Chinese Journal of Cancer2013，32，6： | 13 |
| 2 | VEGF-D promotes spread of tumor cells via the lymphatic显示文摘 | Stacker SA Caesar C Baldwin ME | 2004 | Nat Med2004，7，2： | 1 |
| 3 | Targeting lymphangiogene prevent tumourmetastasis显示文摘 | Aehen MG Mann GB Stacker SA | 2006 | Br J Cancer2006，94，10： | 1 |
| 4 | VEGF-D pro- motes tumor metastasis by regulating prostaglandins pro- duced by the collecting lymphatic endothelium显示文摘 | Karnezis T Shayan R Stacker S | 2012 | Can- cer Cei12012，21，2： | 1 |
| 5 | Lymphatic vessels in cancer metastasis: Bridging the gaps显示文摘 | Shayan R Achen MG Stacker SA | 2006 | Carcinogenesis2006，27，9： | 1 |
| 6 | VEGF-D promotes the metastasis spread of tumor cells via the lymphatics显示文摘 | Stacker SA Caesar C Baldwin ME | 2001 | Nat Med2001，7，2： | 1 |
| 7 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics显示文摘 | Caesar C Baldwin ME | 2001 | Nat Med2001，7，2： | 1 |
| 8 | Molecular control of lymphatic metastasis 显示文摘 | Achen MG Stacker SA | 2008 | Ann N Y Acad Sci2008，31，11： | 1 |
| 9 | Molecular control of lymphatic metasta- sis显示文摘 | Aehen M G Stacker S A | 2008 | Ann N Y Acad Sci2008，1131，5： | 1 |
| 10 | Tumor lymphangiogenesis and metastatic spread-New players begin to emerge显示文摘 | Achen MG Stacker SA | 2006 | International Journal of Cancer2006，，08： | 1 |
| 11 | Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy:a pilot study显示文摘 | Lefebvre PP Stacker H | 2002 | Acta Otolaryngol2002，122，： | 1 |
| 12 | VEGF-D promoes the metastatic spread of tumor cells via the lymphatics显示文摘 | Caesar C Baldwin ME | 2001 | Nat Med2001，7，2： | 1 |
| 13 | Focus on lymphangiogenesis in tumor metastasis显示文摘 | ACHEN MG MCCOLL BK STACKER SA | 2005 | Cancer Cell2005，，2： | 1 |
| 14 | Targeting lymphangiogenesis to prevent tumour metastasis显示文摘 | Achen MG Mann GB Stacker SA | 2006 | Br J Cancer2006，94，10： | 1 |
| 15 | Focus on lymphangiogenesis in tumor metastasis显示文摘 | McColl BK Stacker SA | 2005 | Cancer Cell2005，7，2： | 1 |
| 16 | Lymphangio- genesis and cancer metastasis显示文摘 | Stacker SA Achen MG Jussila L | 2002 | Nat Rev Cancer2002，2，8： | 1 |
| 17 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics显示文摘 | Stacker SA Caesar C Baldwin ME Thornton GE Williams RA Prevo R | 2001 | Nat Med2001，7，2： | 1 |
| 18 | From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in canc, er therapy 显示文摘 | Stacker S A Achen M G | 2008 | Lymphat Res Biol2008，6，34： | 1 |
| 19 | Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor 显示文摘 | Stacker SA Wills AF | 1996 | Cancer Res1996，56，2： | 1 |
| 20 | VEGFD promotes the metastatic spread of tumor cells via the lymphatics 显示文摘 | Stacker SA Caesar C Baldwin ME ct al | 2001 | Nat Med2001，7，2： | 1 |
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