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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Safety and efficacy of protease inhibitors to treat hepatitis C after liver transplantation: A multicenter experience显示文摘 | Audrey Coilly Bruno Roche Jér?me Dumortier Vincent Leroy Danielle Botta-Fridlund Sylvie Radenne Georges-Philippe Pageaux Si-Nafaa Si-Ahmed Olivier Guillaud Teresa Maria Antonini Stéphanie Ha?m-Boukobza Anne-Marie Roque-Afonso Didier Samuel Jean-Charles Du | 2014 | Journal of Hepatology2014，，1： | 2 |
| 4 | Offpump coronary bypass is associated with improved riskadjusted outcomes显示文摘 | Plomondon ME Cleveland JC Ludwig ST | 2001 | Am Thorac Surg2001，72，： | 1 |
| 5 | Risk for perinatal HIV-1 transmission according to maternal immunologic,virologic,and placental factors显示文摘 | St Louis ME Kamenga M Brown C | 1993 | JAMA1993，269，22： | 1 |
| 6 | Human angiostatin inhibits murine hemangioendothelioma tumor grow in vivo显示文摘 | Gately ST Quevedo ME | 1997 | Cancer Res1997，57，： | 1 |
| 7 | Gender differences in autoim- mune disease 显示文摘 | Ngo ST Steyn FJ Me Combe PA | 2014 | Front Neuroendocrinol2014，35，3： | 1 |
| 8 | Mullerianinhibiting substance inhibits cytochrome P450 aromatase activity in human granulosa lutein cell culture显示文摘 | Grossman MP Nakajima ST Fallat ME | 2008 | Fertil Steril2008，89，5： | 1 |
| 9 | Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart 显示文摘 | Saavedra WF Paolocci N St John ME | 2002 | Circ Res2002，90，3： | 1 |
| 10 | Relationship between the ischemic threshold at the onset of wall-motion abnormality on semisupine exercise echocardiography and the extent of coronary artery disease显示文摘 | Elsa Abitbol Jean-Luc Monin Jér?me Garot Mehrane Monchi Stéphanie Russel Anne-Marie Duval Pascal Gueret | 2003 | Journal of the American Society of Echocardiography2003，，2： | 1 |
| 11 | Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation显示文摘 | de Dios ST Bruemmer D Dilley RJ Ivey ME Jennings GL Law RE | 2003 | Circulation2003，107，： | 1 |
| 12 | Untangling the persistence of syphilis in the South显示文摘 | St Louis ME Farley TA Aral SO | 1996 | Sex Transm Dis1996，23，1： | 1 |
| 13 | Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive and glaucomatous eyes 显示文摘 | Mistlberger A Liebmann JM Greenfield DS Pons ME Hoh ST Ishikawa H | 1999 | Ophthalmology1999，106，10： | 1 |
| 14 | Off pump Coronary artery bypass is associated with improved risk adjusted outcomes显示文摘 | Plomondon ME Cleveland JC Ludwig ST | 2001 | Ann Thorac Surg2001，72，1： | 1 |
| 15 | Follicular fluid of single follicles from women with PCOS contains higher levels of mullerian inhibiting substance显示文摘 | Nakajima ST McClure ME | 2007 | Fertil Steril2007，881，： | 1 |
| 16 | Follicular fluid of single follicles from women with PCOS contains higher levels of mullerianinhibiting substance显示文摘 | Ku LT Nakajima ST McClure ME | 2007 | Fertil Steril2007，881，： | 1 |
| 17 | Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart显示文摘 | Saavedra WF Paolocci N St John ME Skaf MW Stewart GC Xie JS | 2002 | Circ Res2002，90，： | 1 |
| 18 | Recurrent cellular angiofi- broma of the value显示文摘 | Me Cluggage WG Perenyei M Irwin ST | 2002 | J Clin Patho12002，55，6： | 1 |
| 19 | Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo显示文摘 | Lannutti BJ Gately ST Quevedo ME | 1997 | Cancer Res1997，57，23： | 1 |
| 20 | Hybrid coronary revascularization versus off-pump coronary artery bypass for the treatment of left main coronary stenosis显示文摘 | Halkos ME Rab ST Vassiliades TA | | 0，，： | 1 |
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