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| 1 | Epidemiology of Helicobacter pylori among multiracial community in Northern Peninsular,Malaysia:effect of age across race and gender显示文摘Objective:To study the epidemiology of Helicobacter pylori(H.pylori) infection according to age group.Methods:H.pylori infection data among 1 965 consecutive patients referred to the Endoscopy Unit collected at Sungai Petani Hospital for oesophagogastro-duodenoscopy(OGD). The patients were divided into 9 age groups(10-19,20-29,30-39,40-49,50-59,60-69,70-79, 80-89 and 90-99 years).In addition these groups were further divided into three minor group namely young adults(10-39),older adults(40-69) and geriatric groups(70-99).Results:Overall prevalence of infection of H.pylori was analyzed and found that the prevalence increase with age (P<0.05).When the patients divided by ethnic and gender group with age,prevalence rate among young adults and older adults significantly higher(P<0.05) compared to geriatric groups across all races and gender(P<0.05).Furthermore,significantly higher number of males were infected compared to female(P<0.05) but such trend was only observed among older adult groups.In addition,there is a significant differences in H.pylori infection prevalence rates among ethnic groups(highest in Indians adults,followed Chinese and low in Malays,P<0.05).Conclusions: The overall prevalence of H.pylori did increase with age group across ethnicity and gender,in Northern Peninsular Malaysia. | Sreenivasan Sasidharan Subramanion Jo Thy Lachumy Manickam Ravichandran Lachimanan Yoga Latha Surasa Rao Surya Gegu | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 11 |
| 2 | Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L显示文摘Objective:To assess antioxidant activities of different parts of Euphorbia hirta(E.hirta),and to search for new sources of safe and inexpensive antioxidants.Methods:Samples of leaves,stems, flowers and roots from E.hirta were tested for total phenolic content,and flavonoids content and in vitro antioxidant activity by diphenyl-1-picrylhydrazyl(DPPH) assay and reducing power was measured using cyanoferrate method.Results:The leaves extract exhibited a maximum DPPH scavenging activity of(72.96±0.78)%followed by the flowers,roots and stems whose scavenging activities were(52.45±0.66)%,(48.59±0.97)%,and(44.42±0.94)%,respectively.The standard butylated hydroxytoluene(BHT) was(75.13±0.75)%.The IC50,for leaves,flowers,roots,stems and BHT were 0.803,0.972,0.989,1.358 and 0.794 mg/mL,respectively.The reducing power of the leaves extract was comparable with that of ascorbic acid and found to be dose dependent. Leaves extract had the highest total phenolic content[(206.17±1.95) mg GAE/g],followed by flowers,roots and stems extracts which were(117.08±3.10) mg GAE/g,(83.15±1.19) mg GAE/g,and (65.70±1.72) mg GAE/g,respectively.On the other hand,total flavonoids content also from leave had the highest value[(37.970±0.003) mg CEQ/g],followed by flowers,roots and stems extracts which were(35.200±0.002) mg CEQ/g,(24.350±0.006) mg CEQ/g,and(24.120±0.004) mg CEQ/ g,respectively.HPTLC bioautography analysis of phenolic and antioxidant substance revealed phenolic compounds.Phytochemical screening of E.hirta leaf extract revealed the presence of reducing sugars,terpenoids,alkaloids,steroids,tannins,flavanoids and phenolic compounds. Conclusions:These results suggeste that E.hirta have strong antioxidant potential.Further study is necessary for isolation and characterization of the active antioxidant agents,which can be used to treat various oxidative stress-related diseases. | Abu Arra Basma Zuraini Zakaria Lacimanan Yoga Latha Sreenivasan Sasidharan | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 7 |
| 3 | Morphological, Physical, Mechanical, Chemical and Thermal Characterization of Sustainable Indian Areca Fruit Husk Fibers (Areca Catechu L.) as Potential Alternate for Hazardous Synthetic Fibers显示文摘 | J. S. Binoj R. Edwin Raj V. S. Sreenivasan C. Rexin Thusnavis | 2016 | Journal of Bionic Engineering2016，13，1： | 6 |
| 4 | Pharmacological activity,phytochemical analysis and toxicity of methanol extract of Etlingera elatior(torch ginger) flowers显示文摘Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior(E.elatior).Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the extract.The pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration(MIC) of metabolic flower extract.The antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal strains.Apart from that,the methanolic extract of E.elatior flower was further tested in vivo toxicity using the brine shrimp lethality test.Moreover,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical(DPPH) assay.Results:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/mL.The brine shrimp lethality test exhibited no significant toxicity(LC50= 2.52 mg/mL) against Artemia salina.The E.elatior flower extract with high LC50 value signified that this plant is not toxic to humans.While the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were absent.The concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC50) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/mL.Conclusions:These findings indicate that the extract of E.elatior flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products. | Subramanion Jo Thy Lachumy Sreenivasan Sasidharan Velio Sumathy Zakaria Zuraini | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 5 |
| 5 | Antioxidant and antibacterial activity of different parts of Leucas aspera显示文摘Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v)methanol.The methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay.Results:All the extracts showed moderate to potent antioxidant activity,among which the root extract demonstrated the strongest antioxidant activity with the IC_(50)value of 6.552μg/mL.Methanol extract of root possessed antioxidant activity near the range of vitamin E and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of root,flower,leaf and stem showed notable antibacterial activity against tested microorganisms.The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms,at a concentration of 100 mg/mL.In the brine shrimp lethality bioassay,it was evident that the methanol root extract did not show significant toxicity.The LC_(50)value for 12 h and 24 h observation was 2.890 mg/mL and 1.417 mg/mL,respectively.Conclusions:The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products. | Ai Lan Chew Jeyanthi James Antony Jessica Sreenivasan Sasidharan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 4 |
| 6 | Isolation and identification of Salmonella from curry samples and its sensitivity to commercial antibiotics and aqueous extracts of Camelia sinensis(L.) and Trachyspermum ammi(L.)显示文摘Objective:To isolate Salmonella from curry samples and to evaluate the drug sensitivity of the food-borne Salmonella and its susceptibility to specific plant extracts.Methods:Salmonella was isolated from the curry samples by standard microbiological methods and was confirmed by biochemical tests.The antibiotic susceptibility test was conducted by disc diffusion method using commercially available antibiotics such as ampicillin,tetracycline,chloramphenicol,kanamycin,and penicillin.In addition,the susceptibility of the food-borne Salmonella was also evaluated against the aqueous extracts of Camelia sinensis(L.) Theaceae(tea leaves) and the Trachyspermum ammi(L.) Apiaceae(ajwain or omum seeds).Results:Out of fifty curry samples,only seven samples were identified to have Salmonella contamination.The Salmonella isolates showed a significant drug resistance pattern except for kanamycin.The plant extracts showed a considerable antibacterial activity against the isolates,indicating the presence of antimicrobial principle which can be exploited after complete pharmacological investigations.Conclusions:The present study demonstrates the occurrence of Salmonella in the curry samples,and shows significant drug resistance against most of the commercially available antibiotics,except kanamycin.Antimicrobial effect of the plant extracts against the food-bone Salmonella suggests that dietary including medicinal herbs would be one strategy to manage food borne pathogens. | Thanes Gunasegaran Xavier Rathinam Marimuthu Kasi Kathiresan Sathasivam Sasidharan Sreenivasan Sreeramanan Subramaniam | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 3 |
| 7 | A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta L.leaf extract in vitro显示文摘Objective:To determine the major changes in the microstructure of Candida albicans(C. albicans) after treatment with Euphorbia hirta(E.hirta) L.leaf extract.Methods:Transmission electron microscopy was used to study the ultrastructural changes caused by E.hirta extract on C. albicans cells al various exposure time.Results:It was found that the main abnormalities were the alterations in morphology,lysis and complete collapse of the yeast cells after 36 h of exposure to the extract.Whereas the control cultures showed a typical morphology of Candida with a uniform central density,typically structured nucleus,and a cytoplasm with several elements of endomembrane system and enveloped by a regular,intact cell wall.Conclusions:The significant antifungal activity shown by this methanol extract of E.hirta L.suggests its potential against infections caused by C.albicans.The extract may be developed as an anticandidal agent. | Abu Arra Basma Zakaria Zuraini Sreenivasan Sasidharan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 3 |
| 8 | In vivo toxicity study of Lantana camara显示文摘Objective:To investigate the toxicity of methanol extract of various parts(Root,Stem,Leaf, Flower and Fruit) of Lantana camara(L.Camara) in Artemia salina.Methods:The methanol extracts of L.camara were tested for in vivo brine shrimp lethality assay.Results:All the tested extract exhibited very low toxicity on brine shrimp larva.The results showed that the root extract was the most toxic part of L.camara and may have potential as anticancer agent.Conclusions: Methanolic extract of L.camara is relatively safe on short-term exposure. | Badakhshan Mahdi Pour Sreenivasan Sasidharan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 9 | Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7cell line model using comet assay显示文摘Objective:To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta(E.hirta)in MCF-7 cell line model using comet assay.Methods:The cytotoxicity of E.hirta extract was investigated by employing brine shrimp lethality assay and the genotoxicity of E.hirta was assessed by using Comet assay.Results:Both toxicity tests exhibited significant toxicity result.In the comet assay,the E.hirta extract exhibited genotoxicity effects against MCF-7 DNA in a time-dependent manner by increasing mean percentage of DNA damage.The extract of E.hirta showed significant toxicity against brine shrimp with an LC_(50)value of 620.382μg/mL(24 h).Comparison with positive control potassium dichroniate signifies that cytotoxicity exhibited by the methanol extract might have moderate activity.Conclusion:The present work confirmed the cytotoxicity and genotoxicity of E.hirta.However,the observed toxicity of E.hta extracts needs to be confirmed in additional studies. | Kwan Yuet Ping Ibrahim Darah Yeng Chen Sreenivasan Sasidharan | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 2 |
| 10 | Analytical approach for the design of convoluted air suspension and experimental validation显示文摘An improved analytical design to investigate the static stiffness of a convoluted air spring is developed and presented in this article.An air spring provides improved ride comfort by achieving variable volume at various strokes of the suspension.An analytical relation is derived to calculate the volume and the rate of change in the volume of the convoluted bellow with respect to various suspension heights.This expression is used in the equation to calculate the variable stiffness of the bellow.The obtained analytical characteristics are validated with a detailed experiment to test the static vertical stiffness of the air spring.The convoluted air bellow is tested in an Avery spring-testing apparatus for various loads.The bellow is modeled in the ABAQUS environment to perform finite element analysis(FEA)to understand and visualize the deflection of the bellow at various elevated internal pressures and external loads.The proposed air spring model is a fiber-reinforced rubber bellow enclosed between two metal plates.The Mooney-Rivlin material model was used to model the hyperelastic rubber material for FEA.From the results,it is observed that the experimental and analytical results match with a minor error of 7.54%.The derived relations and validations would provide design guidance at the developmental stage of air bellows.These expressions would also play a major role in designing an effective active air suspension system by accurately calculating the required stiffness at various loads. | Gokul Prassad Sreenivasan Malar Mohan Keppanan | 2019 | Acta Mechanica Sinica2019，35，5： | 2 |
| 11 | Effect of near adds on the variability of accommodative response in myopic children 显示文摘 | Sreenivasan V Irving EL Bobier WR | 2011 | Ophthalmie Physiol Opt2011，31，： | 1 |
| 12 | Parameteters Related to Clothing Comfort-A New Approach for Measuring Moisture Transport Through Fabrics显示文摘 | Sreenivasan S Patel G S Nachane R P | 1990 | Indian Journal of Fabrics & Textile Research1990，，9： | 1 |
| 13 | An efficient “one pot” synthesis of isoflavone 显示文摘 | Sreenivasan B Muraleedharan GN | 2000 | Synth Communic2000，30，： | 1 |
| 14 | Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase 显示文摘 | Manna SK Sarkar A Sreenivasan Y | 2006 | Eur J Immunol2006，36，3： | 1 |
| 15 | Numerical simula-tions of Rayleigh-Benard convection for Prandtl numbers between 10^-1 and 10^4 and Rayleigh numbers between 10^5 and 10^9显示文摘 | Silano G Sreenivasan K R Verzicco R | | 0，，： | 1 |
| 16 | Stability of uhramer as copy number standards in real-time PC R 显示文摘 | Viljoen CD Thompson GG Sreenivasan S | 2013 | Gene2013，516，1： | 1 |
| 17 | A test of gradient transport and its generalizations显示文摘 | Tavoularis S Corrsin S | 1983 | Turbulent Shear Flows1983，3，1： | 1 |
| 18 | Beta-D-glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappa B but potentiates apoptosis显示文摘 | Sarkar A Sreenivasan Y Ramesh GT | 2004 | J Biol Chem2004，279，： | 1 |
| 19 | Stability and traction control of an actively actuated micro-rover 显示文摘 | Sreenivasan S V Wilcox B H | 1994 | Journal of Robotic Systems1994，11，6： | 1 |
| 20 | Prevalence and antimicrobial resistance of Salmonella enteritidis and other salmonellas in the eggs and eggstoring trays from retail mar- kets of Coimbatore, South India显示文摘 | Suresh T Hatha A A Sreenivasan D | 2006 | Food microbiol2006，23，3： | 1 |
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