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| 1 | Monocytes in systematic inflammatory response syndrome:Differences between sepsis and acute pancreatitis显示文摘AIM: To unravel the differences between systematic in- flammatory response syndrome (SIRS) of acute pancre- atitis compared to the same syndrome in sepsis. METHODS: Twenty-five patients were enrolled, 12 with sepsis and 13 acute pancreatitis. After diagnosis 20 ml blood was sampled. Half were assayed for isolation of monocytes and 10 ml was centrifuged for serum test of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6). Half of monocytes were incubated in the presence of patients’ serum and supernatants were collected. The other half was treated for estimation of optical photom- etry under caspase-3 inhibition. TNFα and IL-6 were es- timated by an enzyme immunoassay. RESULTS: median ± SE of serum IL-6 in septic patients and acute pancreatitis patients was 192.30 ± 35.40 ng/L and 21.00 ± 16.05 ng/L, respectively (P < 0.01). Re- spective values of caspase-3 were 0.94 ± 0.17 pmol/min 104 cells and 0.34 ± 0.09 pmol/min 104 cells (P < 0.05). IL-6 of monocyte supernatants of patients with sepsis was significantly increased after addition of patients’ serum, while that of patients with acute pancreatitis did not show significant difference. CONCLUSION: The data have shown that monocyte activity is different between acute pancreatitis and sepsis. This phenomenon might be explained as a different pathway to the pro-inflammatory cytokines release or could be a novel anti-inflammatory response in acute pancreatitis. | Vassilios Koussoulas Michalis Tzivras Vassiliki Karagianni Ekaterini Spyridaki Diamantis Plachouras Helen Giamarellou Evangelos J Giamarellos-Bourboulis | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 2 | Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells(strem-1) in peptic ulcer disease显示文摘AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer. METHODS: Seventy two patients were enrolled; 35 with duodenal, 21 with gastric ulcer and 16 with chronic gastritis. Patients were endoscoped and gastric juice was aspirated. Patients with duodenal and gastric ulcer underwent a second endoscopy post-treatment. Biopsies were incubated in the absence/presence of endotoxins or gastric juice. Supernatants were collected and sTREM-1 and TNFα were measured by enzyme immunoabsorbent assays. Scoring of gastritis was performed before and after treatment according to updated Sydney score. RESULTS: Patients with duodenal and gastric ulcer and those with chronic gastritis had similar scores of gastritis. sTREM-1 was higher in supernatants of tissue samples of H pylori-positive than of H pylori-negative patients with gastric ulcer. Median (± SE) sTREM-1 was found increased in supernatants of patients with gastric ulcer before treatment (203.21 ± 88.91 pg/1000 cells) compared to supernatants either from the same patients post-treatment (8.23 ± 5.79 pg/1000 cells) or from patients with chronic gastritis (6.21 ± 0.71 pg/1000 cells) (P < 0.001 and < 0.001, respectively). Similar differences for sTREM-1 were recorded among LPS-stimulated tissue samples of patients (P = 0.001). Similar differences were not found for TNFα. Positive correlations were found between sTREM-1 of supernatants from patients withboth duodenal and gastric ulcer before treatment and the degree of infiltration of neutrophils and monocytes. CONCLUSION: sTREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer. sTREM-1 was released at the presence of H pylori from the inflamed gastric mucosa in the field of gastric ulcer. | Vassilios Koussoulas Spyridon Vassiliou Ekaterini Spyridaki Maria Demonakou Ilia Vaki Charalambos Barbatzas Helen Giamarellou Evangelos J Giamarellos-Bourboulis | 2007 | World Journal of Gastroenterology2007，13，34： | 11 |
| 3 | Liposarcoma of the stomach: A rare case report显示文摘Liposarcoma is the most common soft tissue sarcoma and accounts for 15%-20% of all mesenchymal malignancies. The tumor occurs most frequently in the limbs, retroperitoneum and rarely has a visceral location. We report a case of a gastric liposarcoma in a male patient. A 68 years old male patient was admitted to hospital for abdominal discomfort and fullness lasting for a month. He reported rare episodes of vomiting. The CT examination revealed a large epigastric mass (8 cm x 4 cm) involving the lesser curvature of the stomach, in contact with the pancreas and gallbladder. Fatty areas within the mass were evident. A total gastrectomy together with cholecystectomy was performed. The histopathological diagnosis was a well differentiated liposarcoma. The patient did not undergo any adjuvant treatment, he is under close follow up and two years later he is disease free. We report this case due to the rarity of this tumor in the stomach (nine cases reported in the literature). | Konstantinos Tepetes Gregory Christodoulidis Michael E Spyridakis Maria Nakou George Koukoulis Konstantinos Hatzitheofilou | 2007 | World Journal of Gastroenterology2007，13，30： | 3 |
| 4 | An examination of factors that affect the credibility of online health information显示文摘 | FREEMAN K S SPYRIDAKIS J H | | 0，，02： | 1 |
| 5 | Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram negtive sepsis显示文摘 | Giamarellos-Bourboulis EJ Tsaganos T Spyridaki E | 2006 | Crit Care2006，10，6： | 1 |
| 6 | An Examination of Factors That Affect the Credibility of Online Health Information显示文摘 | Freeman K S Spyridakis J H | 2004 | Technical Communi cation2004，51，26： | 1 |
| 7 | Acute appendicitis in a duplicated appendix显示文摘 | Christodoulidis G Symeonidis D Spyridakis M | 2012 | Int J Surg Case Rep2012，3，： | 1 |
| 8 | Doping control analysis in human urine by liquid chromatography-eleetrospray ionization ion trap mass spectrometry for the Olympic Games Athena 2004:Determination of corticosteroids and quantification of ephedrines,salbutamol and morphine显示文摘 | MH Spyridaki P Kiousi A Vonaparti | 2006 | Analytica Chimica Acta2006，，： | 1 |
| 9 | Determination of ephedrines in urine by gas chromatography-mass spectrometry显示文摘 | Spyridaki M H E Tsitsimpikou C J | 2001 | Journal of Chromatography B2001，758，2： | 1 |
| 10 | Adult-onset Still's disease: from pathophysiology to targeted therapies显示文摘 | Mavragani CP Spyridakis EG Koutsilieris M | 2012 | Internatil J Inflam2012，2012，87： | 1 |
| 11 | Determination of Xylazine and Its Metabolites by GC - MS in Equine Urine for Doping Analysis 显示文摘 | Spyridaki M H Lyris E Georgoulakis I D | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，35，： | 1 |
| 12 | Earl y changes of CD4-positive lymphocytes and NK ceils in patients with severe gram negative sepsis显示文摘 | Giamarellos-Bourboulis E J Tsaganos T Spyridaki E | 2006 | Critical Care2006，10，6： | 1 |
| 13 | Effect of contact information on the credibility of online health information 显示文摘 | Freeman K S Spyridakis J H | 2009 | IEEE Transactions on Professional Communication2009，52，2： | 1 |
| 14 | Model construction of single crystalline photovoltaic panelsfor real-time simulation 显示文摘 | Spyridaki A Lazaridis M Eleftheriadis K | 2010 | IEEE Energy ConversionCongress & Exposition2010，40，32： | 1 |
| 15 | Endovascular management of a late saccular aortic aneurysm after end- to-end repair of coarctation显示文摘 | Kotoulas C 'Fzilalis V Spyridakis E | 2011 | Monaldi Arch Chest Dis2011，76，4： | 1 |
| 16 | Influence of pulse temporal manipulation on the properties of laser ablated Si ion beams 显示文摘 | KOUDOUMAS E SPYRIDAKI M STOIAN R | 2004 | Thin Solid Films2004，，453454： | 1 |
| 17 | Doping control analysis inhuman urine by liquid chromatogra- phyeletrospray ionization ion trap mass spectrometry for the Olympic Games Athens 2004 : Determination of corti- costeroids and quantification of ephedrines, salbutamol and morphine 显示文摘 | Spyridaki M H Kiousi D Vonaparti A | 2006 | Analytica Chimica Acta2006，573，574： | 1 |
| 18 | Early changes of CD4-positive lymphocytes and NK cells in pa-tients with severe Gram negtive sepsis显示文摘 | Ciamarellos-Bourooulis E J Tsaganos T Spyridaki E | 2006 | Crit Care2006，10，6： | 1 |
| 19 | Doping control analysis in human urine by liquid chromatography-electrospray ionization ion trap mass spectrometry for the Olympic Games Athens 2004: determination of corticosteroids and quantification of ephedrines, salbutamol and morphine显示文摘 | Spyridaki M H Kiousi P Vonaparti A | 2006 | Anal Chim Acta2006，573，1： | 1 |
| 20 | Tissue preserving hepateetomy by a vessel sealing de- vice 显示文摘 | TEPETES K CHRISTODOULIDIS G SPYRIDAKIS E M | 2008 | J Surg Oncol2008，97，2： | 1 |
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