| 3 | Calcium handling:a strategy to fight neurodegeneration in Alzheimer's disease显示文摘In the last few years,preclinical and clinical studies identified the ventral tegmental area(VTA)as one of the first brain regions to be affected in the prodromal phase of Alzheimer's disease(AD).The VTA is a deep midbrain nucleus rich in dopaminergic neurons that innervates and releases dopamine(DA)in several cortical and subcortical brain regions.DA plays a crucial role in the modulation of both cognitive and noncognitive functions and failure of its release underlies both cognitive and neuropsychiatric symptoms in patients with AD. | Livia La Barbera Elena Spoleti Marcello D’Amelio | 2023 | Neural Regeneration Research2023，18，12： | 0 |
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