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| 1 | Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?显示文摘Hepatitis C virus(HCV) affects about 3% of the world'spopulation, with the highest prevalence in individuals under 40. The prevalence in pregnant women varies with geographical distribution(highest in developing countries). Prevalence also increases in sub-populations of women at high risk for blood-transmitted infections. HCV infection in pregnancy represents a non-negligible problem. However, most of the past antiviral regimens cannot be routinely offered to pregnant or breastfeeding women because of their side effects. We briefly reviewed the issue of treatment of HCV infection in pregnant/breastfeeding women focusing on the effects of the new direct-acting antivirals on fertility, pregnancy and lactation in animal studies and on the potential risk for humans based on the pharmacokinetic properties of each drug. Currently, all new therapy regimens are contraindicated in this setting because of lack of sufficient safety information and adequate measures of contraception are still routinely recommended for female patients of childbearing potential. | Anna Maria Spera Tarek Kamal Eldin Grazia Tosone Raffaele Orlando | 2016 | World Journal of Hepatology2016，8，12： | 4 |
| 2 | 一种新颖的诊断小肠通畅功能的工具:应用设定的开放式胶囊 | Spada C. Spera G. Riccioni M. G. Costamagna 王铮 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，12： | 2 |
| 3 | Operational stability of Brevibacterium imperialis CBS 489-74 nitrile hydratase 显示文摘 | Alfani F Cantarella M Spera A | 2001 | J Mol Catal B-Enzym2001，11，46： | 1 |
| 4 | HYBRID MODEL FOR SOLIDIFICATION AND CONVECTION显示文摘 | Curtis M. Oldenburg Frank J. Spera | 1992 | Numerical Heat Transfer Part B: Fundamentals1992，，2： | 1 |
| 5 | IL-10 reducesrat brain injury following focal stroke 显示文摘 | Spera PA Ellison JA Feuerstein GZ | 1998 | Neurosci Lett1998，251，3： | 1 |
| 6 | Isofla-vonoids and Chalcones from Anthyllis hermanniae 显示文摘 | Luisa Pistelli Katya Spera Guido Flamini | 1996 | Phy-tochemistry1996，42，5： | 1 |
| 7 | IL-10 reduces rat brain injury following focal stroke显示文摘 | Spera PA Ellison JA Feuerstein GZ | 1998 | Neurosci Lett1998，25，3： | 1 |
| 8 | IL- 10 reduces rat brain injury following focal stroke 显示文摘 | Spera PA Ellison JA Feuerstein GZ et at | 1998 | Neurosci Lett1998，251，： | 1 |
| 9 | Ischemic preconditioning and brain tolerance:Temporal histological and functional outcomes,protein synthesis requirement,and interleukin-1 receptor antagonist and early gene expression显示文摘 | White RF Spera PA | 1998 | Stroke1998，29，： | 1 |
| 10 | Management of acute postoperative pain after oral surgery显示文摘 | Fletcher MC Spera JF | 2012 | Dent Clin North Am2012，56，1： | 1 |
| 11 | Ischemic preconditioning and brain toleranee ztemporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression 显示文摘 | Barone FC White RF Spera PA | 1998 | Stroke1998，29，： | 1 |
| 12 | IL-10 reduces rat brain injury following focal stroke 显示文摘 | Spera PA Ellison JA Feuerstein GZ | 1998 | Neurosci Lett1998，251，： | 1 |
| 13 | Defining the internet-based supply chain system for mass customized markets显示文摘 | Ghiassi M Spera C | 2003 | Computers & Industrial Engineering2003，45，： | 1 |
| 14 | Ki-67 Labeling index and invasivences among anterior pituitary adenomas:analysis of 1003 cases using the MIB-1 monoclonal antibody显示文摘 | Guiducci A Spera C | 1999 | J Clin Pathol1999，52，： | 1 |
| 15 | Congenital absence of the cervical and petrous internal carotid artery with intercavernous anastomosis显示文摘 | Quint DJ Boulos RS Spera TD | 1989 | AJNR Am J Neuroradiol1989，10，2： | 1 |
| 16 | IL-10 reduces rat brain injury following focal stroke显示文摘 | Spera PA Ellision JA Feaerstein GI | 1998 | Neurosci Lett1998，251，3： | 1 |
| 17 | Ischemic preconditioning and brain tolerance: Temporal histological and functional outcomes, protein synthesis requirement, and IL-1 receptor antagonist and early gene expression 显示文摘 | BARONE F C WHITE R F SPERA P A | 1998 | Stroke1998，29，9： | 1 |
| 18 | Amino acid-based formula as a rescue strategy in feeding very-low-birth-weight infants with intrauterine growth restriction 显示文摘 | Raimondi F Spera AM Sellitto M | 2012 | J Pediatr Gastro- enterol Nutr2012，54，： | 1 |
| 19 | Osteopontin and its integrin receptor alpha(v)beta3 are upregulated during formation of the glial scar after focal stroke显示文摘 | Velier JJ Spera P | 1998 | Stroke1998，29，8： | 1 |
| 20 | IL-10 reduces rat brain injury following focal stroke显示文摘 | Spera PA Ellison JA Feuerstein GZ Barome FC | 1998 | Neurosci Lett1998，251，3： | 1 |
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