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| 1 | Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities显示文摘Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical composition.Methods:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,respectively.These polysaccharide extracts(20 mg/kg b.wt.for 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were evaluated.Results:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,respectively.These polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC group.JCEM,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),respectively.The bioactive polysaccharides in HCC induced rats improved the humoral immune response.The photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological structure.Moreover,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/mL.However,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic effect.Conclusions:The pronounced antitumor activity of sulphated polysaccharide-protein complexes of JCEM and EHEM is due to direct cytotoxic activity,anti-hepatocarcinogensis,and anti-angiogenesis.In addition,JCEM,PCEM and EHEM had an immunostimulatory response and improved the humoral immune response in HCC induced rats. | Azza A.Matloub Hadeer A.Aglan Sahar Salah Mohamed El Souda Mona Elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 7 |
| 2 | 含抗生素污水处理技术研究进展显示文摘抗生素废水成分复杂,色度较高,生物毒性较高,含有多种抑制物质,属于高浓度难降解有机废水。另外,其残留物一般含有浓度不同、种类也不同的抗生素及生产、使用抗生素期间的代谢产物。抗生素废水成分的复杂性,决定其单纯依靠传统的处理方法,即生物组合工艺处理方式并不能达到国家法律、法规所要求的污水排放标准,不达标的废水直接排放会对生态环境造成不可估量的损害,特别是在对生态环境受到日益重视的背景之下,不达标的排放可能会给抗生素生产企业发展带来不容忽视的难题。对近年来国内外污水中抗生素的现状和抗生素废水处理技术(以青霉素类抗生素废水为例)进行了综述,并对抗生素废水处理未来发展的方向进行了展望。 | 郭立新 贾元 SOUDA THANORK 吴佳铭 | 2021 | 长春理工大学学报(自然科学版)2021，44，1： | 2 |
| 3 | Source enumeration in a correlated singed environment 显示文摘 | COZZENS J H SOUDA M J | 1994 | IEEE Trans SP1994，42，2： | 1 |
| 4 | Effects of protonation on the viscoelastic properties of tetradecyldimethylamine oxide micelles 显示文摘 | MAEDA H YAMAMOTO A SOUDA M | 2001 | J Phys Chem B2001，105，23： | 1 |
| 5 | Maspin expression is frequent and correlates with basal markers in triple-negative breast cancer 显示文摘 | Umekita Y Ohi Y Souda M | 2011 | Diagn Pathol2011，16，6： | 1 |
| 6 | Studies on the conditions of blood sampling and storage for liposome-based CH50 assay显示文摘 | Souda N | 1998 | Rinsho Byori1998，46，10： | 1 |
| 7 | Improved long-term survival following complete eradication of esophageal varices by sclerotherapy 显示文摘 | Matsumoto H Suzuki F Souda K | 1999 | Hepatogastroenterology1999，46，25： | 1 |
| 8 | Interfacial reaction of water ice on polycrystalline vanadium and its effects on thermal desorption of water显示文摘 | RYUTARO SOUDA | 2014 | Phys Chem Chem Phys2014，34，16： | 1 |
| 9 | Significance of laparoscopic excisional biopsy for polypoidal lesions of the gallbladder显示文摘 | Toda K Souda S Yoshikawa Y | 1995 | Surg Laparosc Endosc1995，5，： | 1 |
| 10 | Bilateral lung volume reduction surgery via median sternotomy for severe pulmonary emphysema显示文摘 | Date H Goto K Souda R | 1998 | Ann Thorac Surg1998，65，4： | 1 |
| 11 | Renopro- tective effects of Low - dose valsartam in type 2 dia - betic patients with diabetic nephropathy显示文摘 | Suzuki KATSUNORI Souda SATOSHI Ikarash I TOM 00 | 2003 | Diabetes Researe -hand clinical practice2003，51，2： | 1 |
| 12 | XPS studies on silicon carbonitride films prepared by sequential implantation of nitrogen and carbon into silicon 显示文摘 | DENG Z W SOUDA R | 2002 | Diamond and Related Materials2002，11，9： | 1 |
| 13 | Amide bonds assem- ble pili on the surface of bacilli 显示文摘 | BUDZIK J M MARBAFFINI L A SOUDA P | | PNAS0，105，10： | 1 |
| 14 | The clinical usefulness of preoperative CEA determination in gastric cancer显示文摘 | Toshiro Koga MD Tadashi Kano Kuniyasu Souda Naokata Oka Kiyoshi Inokuchi | 1987 | The Japanese Journal of Surgery1987，，5： | 1 |
| 15 | Increased bone mineral density in aged rats with spontaneous mammary dysplasia 显示文摘 | Kawaguchi H Umeldta Y Souda M | 2007 | In Vi- vo2007，21，4： | 1 |
| 16 | Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis 显示文摘 | Kawasaki T Takeshita A Souda K | 1999 | Am J Gastroenterol1999，94，7： | 1 |
| 17 | Characterization ofthe endothelial cell cytoskeleton following HLA class Iligation显示文摘 | Ziegler] ME Souda P Jin YP | 2012 | PLoS One2012，，29： | 1 |
| 18 | Development of high power capacitor charging power supply for pulsed Power applications显示文摘 | Souda M Endo F Yamazaki C | 1991 | IEEE Trans on Industrial Electronics1991，38，6： | 1 |
| 19 | Expression of maspin in colorectal cancer显示文摘 | Umekita Y Souda M Yoshida H | 2006 | In Vivo2006，20，2： | 1 |
| 20 | Anthraquinone glycosides from Cassia roxburghii, and evaluation of its free radi-cal scavenging activity 显示文摘 | El-Toumy S A Souda S S E Mohamed TK | 2012 | Carbohydrate Research2012，360，： | 1 |
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