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| 1 | RhoA/ROCK activation in major pelvic ganglion mediates caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury显示文摘Severe erectile dysfunction(ED)remains a significant side effect among men following surgical intervention for treatment of clinically localized prostate cancer,despite development of nerve-sparing techniques(Weyne et al.,2015a;Sopko and Burnett,2016).The type of axonal injury due to prostatectomy is a classic peripheral neuropathy with | Michael Bell Nikolai A. Sopko Hotaka Matsui Johanna L. Hannan Trinity J. Bivalacqua | 2017 | Neural Regeneration Research2017，12，4： | 3 |
| 2 | Carcinogenic aristolochic acids upon activation by DT-diaphorade form adducts found in DNA of patients with Chinese herbs nephropathy显示文摘 | Stiborova M Frei E Sopko B | 2002 | Carcinogenesis2002，23，4： | 1 |
| 3 | An update on central nervoussystem stimulant formulations in children and adolescents withattention-deficit/hyperactivity disorder 显示文摘 | Chavez B Sopko MA Jr Ehret MJ | 2009 | Ann Pharmacother2009，6，43： | 1 |
| 4 | Bone Marrow Support of the Heart in Pressure Overload Is Lost with Aging显示文摘 | Nikolai A Sopko Benjamin A | 2010 | PLoS One2010，5，2： | 1 |
| 5 | Significance of Thy- mosin b4 and Implication of PINCH-I-ILK-a-Parvin (PIP) Complex in Human Dilated Cardiomyopathy显示文摘 | Sopko N Qin Y Finan A | 2011 | PLoS One2011，6，20： | 1 |
| 6 | Acute heart failure syndromes:current state and framework for future research显示文摘 | Gheorghiade M Zannad F Sopko G | 2005 | Circulation2005，112，25： | 1 |
| 7 | The feasibility of an early hospital discharge following chemotherapy for the acute myeloid leukemia显示文摘 | Sopko L Sabty FA Rimajova V | | 0，，： | 1 |
| 8 | Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P) H : quinone oxidoreductase 显示文摘 | Stibomva M Frei E Sopko B | 2003 | Carcinogenesis2003，24，10： | 1 |
| 9 | Navigating the cross- roads of coronary artery disease and heart failure 显示文摘 | Gheorghiade M Sopko G De Luca L | 2006 | Circula- tion2006，114，11： | 1 |
| 10 | Acinetobacter-- serious danger for burn patients显示文摘 | Babik J Bodndrovd L Sopko K | 2008 | Acta Chit Plast2008，，： | 1 |
| 11 | Acute heart failure syndromes: current state and framework for future research 显示文摘 | Gheorghiade M Zannad F Sopko G | 2005 | Circulation2005，112，25： | 1 |
| 12 | Comparison of surgical and medical group survival in patients with left main coronary artery disease: long-term CASS experience 显示文摘 | Caraccido EA Davis KB Sopko G et at | 1995 | Circulation1995，91，： | 1 |
| 13 | Women and cardiovascular heart disease: clinical implications from the women's Ischemia syndrome evaluation ( WISE ) study : are we smarter 显示文摘 | Lerman A Sopko G | 2006 | J Am Coll Cardiol2006，47，3： | 1 |
| 14 | Molecular-cytogenetic study of the aborted fetuses in women withreproductive function disorders显示文摘 | Tavokina LV Sopko NI Khazhilenko KG | 2006 | Tsitol Genet2006，40，： | 1 |
| 15 | Chemokine upregulation in response to anal sphincter and pudendal nerve injury: potential signals for stem cell homing 显示文摘 | Salcedo L Sopko N Jiang HH | 2011 | Int J Colorectal Dis2011，26，12： | 1 |
| 16 | Comparison of surgical and medical group survival in patients with left main coronary artery disease:long term CASS experience显示文摘 | Caracciolo EA Pavis KB Sopko G etAL | 1995 | Circulation1995，91，： | 1 |
| 17 | Significance of thymosin beta4 and implication of PINCH-l-ILK-alpha-parvin (PIP) complex in human dilated cardiomyopathy显示文摘 | Sopko N Qin Y Finan A | 2011 | PLoS One2011，6，20： | 1 |
| 18 | 肺动脉导管对重症患者的影响——随机临床试验汇总分析显示文摘背景:评估肺动脉导管(pulmonary artery catheter,PAC)的随机临床试验(randomized clinical trials,RCTs)一直受到研究样本量较小的限制。一些非随机研究表明,PAC的应用会增加患者的发病率和死亡率。
目的:评估PAC对重症患者的影响。数据来源:在MEDLINE(1985~2005年)数据库、Cochrane对照试验登记站(1988~2005年)、国立卫生研究院ClinicalTrials.gov网站数据库以及美国食品与药物管理局网站上对将患者随机分配至PAC组和非PAC组的RCTs进行检索。在重症心力衰竭患者中进行的ESCAPE试验结果也被纳入。检索词包括肺动脉导管、右心导管、导管和Swan-Ganz。
研究选择:符合条件的研究应包含如下患者:接受手术治疗的患者,进入重症监护病房(intensive care unit,ICU)的患者,因重度心力衰竭入院或者诊断为急性呼吸窘迫综合征和/或败血症的患者。作为观察指标,入选的研究报告了患者死亡、住院天数或ICU住院天数。
数据提取:各研究的入选标准、基线特征、干预措施、预后以及方法学质量的信息由2位作者提取。不同意见通过协商达成共识解决。
数据综合:13项RCTs共包含5051例随机患者。各试验的血流动力学目标和治疗策略各不相同。使用随机效应模型估计患者死亡、住院天数以及使用变力和静脉血管扩张药物的优势比(odds ratios,ORs)。死亡率的合并OR为1.04(95%可信区间[confidence interval,CI],0.90~1.20;P=0.59)。PAC组平均住院天数与非PAC组平均住院天数的差为0.11天(95%CI,-0.51~0.74;P=0.73)。PAC与变力药物(OR,1.58;95%CI,1.19~2.12;P=0.002)和静脉内血管扩张药物的使用率较高相关(OR,2.35;95%CI,1.75~3.15;P〈0.001)。
结论:对于重症患者而言,PAC的使用既不增加总体死亡率或住院天数,也没有给患者带来益处。尽管相关RCTs已进行了近20年,但是仍未得出可以提高患者存活率的明确的PAC使用策略。PAC对临床预后的中性作用可能为对其在各种重症患者的使用缺乏有效的循证治疗所致。 | Monica R. Shah Vic Hasselblad Lynne W. Stevenson Cynthia Binanay Christopher M. O'Connor George Sopko Robert M. Califf 陈益和(译) 唐福林(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 1 |
| 19 | Thrombolysis in myocardial infarction investigators, value of rescue percutaneous transluminal coronary angioplasty following unsuccessful thrombolytic therapy in patients with acute myocardial infarction 显示文摘 | McKendall GR Forman S Sopko G | 1995 | Am J Cardiol1995，76，： | 1 |
| 20 | Trends in coronary revas- eularization 1989 to 1997:the Bypass Angioplasty Revaseular- ization Investigation (BARI) survey of procedures 显示文摘 | Holubkov R Detre KM Sopko G | 1999 | Am J Car- diol1999，84，2： | 1 |
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