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| 1 | Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma显示文摘AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients. | Hong Seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan Hong Woo Song Ha Randy L Jirtle | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Laparoscopie versus open simple prosta tectomy an evaluation of morbidity显示文摘 | McCullough T C Heldwein F L Soon S J Galiano M Barret E Cathelineau X | 2009 | J Endourol2009，23，： | 1 |
| 4 | Analysis of the M/G/1 queue with n-policy and multiple vacations显示文摘 | Ho W L Soon S L | 1994 | Journal of Applied Probabality1994，31，： | 1 |
| 5 | Visualization of three dimensional pore morphologies in a high-pressure die-cast Mg Al RE alloy显示文摘 | SOON G L ARUN M G | 2007 | Scrip ta Materialia2007，56，501： | 1 |
| 6 | Highly textured, magnetic Fe(1+x)S nanorods grown on silicon 显示文摘 | Soon J M Goh L Y Loh K P | 2007 | Appl Phys Lett2007，91，08： | 1 |
| 7 | A feasibility study using interactive commercial off-the-shelf computer gaming in upper limb rehabilitation in patients after stroke 显示文摘 | Yong Joo L Soon Yin T Xu D | 2010 | J Rehabil Med2010，42，5： | 1 |
| 8 | An effective 3D seed fill algorithm 显示文摘 | Feng L Soon S H | 1998 | Comput Graph1998，22，5： | 1 |
| 9 | A Global Maximum Power Point tracking Scheme Employing DIRECT Search Algorithm for Photovohaic Systems显示文摘 | Tat L N Kay - Soon L | 2010 | IEEE Transactions on Industrial Electronics2010，57，10： | 1 |
| 10 | Robust SVD-based audio watermarking scheme with differential evolution optimization 显示文摘 | LEI B SOON Y TAN E L | 2013 | IEEE Transactions on Audio Speech and Language Processing2013，21，11： | 1 |
| 11 | TBT toxicity on the marine microalga Nannochloropsis oculata显示文摘 | Sidharthan M Young K S Woul L H Soon P K Shin H W | 2002 | Marine Pollution Bulletin2002，45，112： | 1 |
| 12 | Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell K M He Y Xu Y Chalmers M J Brunzelle J S Zhang H Yang H Jiang H Li J Yong E L Cutler S Zhu J K Griffin P R Melcher K Xu H E | 2012 | Science2012，335，6064： | 1 |
| 13 | Robust SVD-based audio watermarking scheme with differential evolution optimization 显示文摘 | LEI B SOON Y TAN E L | 2013 | IEEE Transactions on Audio Speech and Language Processing2013，21，11： | 1 |
| 14 | Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell KM He Y Xu Y Chalmers MJ Brunzelle JS Zhang H Yang H Jiang H Li J Yong EL Cutler S Zhu JK Griffin PR Melcher K Xu HE | 2012 | Science2012，335，6064： | 1 |
| 15 | Particle filterswith adaptive resampling technique applied to rela-tive positioning using GPS carrier-phase measure-ments显示文摘 | Hwang Soon Sik Speyer Jason L | 2011 | IEEE Transactions on Control SystemsTechnology2011，19，6： | 1 |
| 16 | Sequential VATS lung volume reduction surgery:prolongation of benefits derived after the initial operation显示文摘 | Soon S Y Saidi G Ong M L | 2003 | Eur J Cardiothorac Surg2003，24，： | 1 |
| 17 | Challenges in the Detection and Attribution of Northern Hemisphere Surface Temperature Trends Since 1850显示文摘Since 2007,the Intergovernmental Panel on Climate Change(IPCC)has heavily relied on the comparison between global climate model hindcasts and global surface temperature(ST)estimates for concluding that post-1950s global warming is mostly human-caused.In Connolly et al.,we cautioned that this approach to the detection and attribution of climate change was highly dependent on the choice of Total Solar Irradiance(TSI)and ST data sets.We compiled 16 TSI and five ST data sets and found by altering the choice of TSI or ST,one could(prematurely)conclude anything from the warming being“mostly human-caused”to“mostly natural.”Richardson and Benestad suggested our analysis was“erroneous”and“flawed”because we did not use a multilinear regression.They argued that applying a multilinear regression to one of the five ST series re-affirmed the IPCC's attribution statement.They also objected that many of the published TSI data sets were out-of-date.However,here we show that when applying multilinear regression analysis to an expanded and updated data set of 27 TSI series,the original conclusions of Connolly et al.are confirmed for all five ST data sets.Therefore,it is still unclear whether the observed warming is mostly human-caused,mostly natural or some combination of both. | Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.J.Butler Rodolfo Gustavo Cionco Ana G.Elias Valery M.Fedorov Hermann Harde Gregory W.Henry Douglas V.Hoyt Ole Humlum David R.Legates Nicola Scafetta Jan-Erik Solheim LászlóSzarka Víctor M.Velasco Herrera Hong Yan Weijia Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，10： | 1 |
| 18 | Studies on the stubilitiesof red pepper oleoresin 显示文摘 | SOON K C HEE L G SENL B J | 1987 | Pharm Sci1987，16，3： | 1 |
| 19 | A PoLyacetylene and fiavonoids from Cirsium rhinoceros显示文摘 | Soon H Y Hyun J K Ik S L | 2003 | Arch Pharm Res2003，26，2： | 1 |
| 20 | Acrat lentigi- nous melanoma mimicking benign disease: the emory experience 显示文摘 | Soon S L Solomon A R Jr Papadopoulos D | 2003 | J Am Acad Dermatol2003，48，2： | 1 |
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